Abstract: The disclosure provides a CD169 high affinity anti-tumor compound (TCC-Neu5A) and its preparation and application. The CD169 high affinity anti-tumor compound is a small molecule compound, which has specific and broad-spectrum tumor killing characteristics. TCC-Neu5Ac could targets tumor cells in vivo and metabolize onto a surface of the tumor cells to form CD169 ligands. These tumor cells are recognized and phagocytized by CD169-positive macrophages, which then release tumor-related antigens and present them to other immune cells, triggering an anti-tumor immune response. The CD169 high affinity anti-tumor compound provided by the disclosure is effective for a variety of tumors and has an inhibitory effect on tumor metastasis. In addition, the CD169 high affinity anti-tumor compound provided by the disclosure can not only be injected but also be orally administered. Cytotoxicity and animal toxicity of the CD169 high affinity anti-tumor compound are very low.

Abstract: The present invention relates to aromatic ring or heteroaromatic ring compounds, a preparation method therefor and a medical use thereof. Particularly, the present invention relates to a compound as shown in general formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound and a use thereof as an agonist for a farnesoid X receptor (FXR). The compound and the pharmaceutical composition comprising the compound can be used for treating and/or preventing FXR activity-related diseases, for example, cholestatic symptoms, diabetes and complications thereof, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatosis heptitis (NASH), obesity or metabolic syndrome (diseases associated with dyslipidemia, diabetes, abnormally high body weight index), cardiovascular diseases and so on. The definition of each substituent in the general formula (I) is the same as that in the description.

Abstract: The present disclosure discloses melatonin derivatives, a method thereof, and a use thereof. The method comprises: dissolving melatonin in a solvent, adding a catalyst while maintaining the solvent at 0° C. to obtain a first reaction solution, stirring the first reaction solution, adding reactants in the first reaction solution, continually stirring at room temperature or at refluxing reaction temperature until, when analyzing by thin layer chromatography, the first reaction solution is fully reacted, quenching the reaction with ice water, concentrating the first reaction solution to obtain a residue of the first reaction solution, and purifying the residue of the first reaction solution by column chromatography to obtain the melatonin derivatives.

Abstract: The present invention relates to a spiro compound and medical uses thereof. Specifically, the present invention relates to a spiro compound represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the same, and is used as an acetyl-Coenzyme A carboxylase (ACC) inhibitor and is used for treating diseases associated with ACC activity. Each substituent in the general formula (I) is as defined in description.

Abstract: A method of repairing a display panel comprising: determining a pixel where a bright spot defect resides and a position of the bright spot in the pixel; setting a repair region, the repair region being a region in the pixel including the bright spot defect and having an area smaller than that of a single pixel region; forming a black material layer in the repair region, the black material layer being used for preventing light emitted from a directly-below portion thereof from leaving a display surface of the display panel.

Abstract: The present disclosure discloses melatonin derivatives, a method thereof, and a use thereof. The method comprises: dissolving melatonin in a solvent, adding a catalyst while maintaining the solvent at 0° C. to obtain a first reaction solution, stirring the first reaction solution, adding reactants in the first reaction solution, continually stirring at room temperature or at refluxing reaction temperature until, when analyzing by thin layer chromatography, the first reaction solution is fully reacted, quenching the reaction with ice water, concentrating the first reaction solution to obtain a residue of the first reaction solution, and purifying the residue of the first reaction solution by column chromatography to obtain the melatonin derivatives.

Abstract: A method of repairing a display panel comprising: determining a pixel where a bright spot defect resides and a position of the bright spot in the pixel; setting a repair region, the repair region being a region in the pixel including the bright spot defect and having an area smaller than that of a single pixel region; forming a black material layer in the repair region, the black material layer being used for preventing light emitted from a directly-below portion thereof from leaving a display surface of the display panel.

Abstract: The present disclosure discloses carbohydrate derivatives used for surface modification of immune cells, use thereof, and method thereof. The carbohydrate derivatives are 9-carbon monosaccharide sialic acid derivatives modified at C9 position by targeting substituents. The surfaces of the immune cells (T cells, NK cells, macrophages, DC cells, B cells, or granulocytes) is modified by the carbohydrate derivatives to obtain modified immune cells, so that the modified immune cells can be used for treatment of tumors or other diseases to obtain good effects.

Abstract: In one aspect, a power system comprises a power bus, a plurality of energy-storage modules, and a controller. Each energy-storage module is coupled to the power bus and comprises an energy-storage device configured to store energy, an electrical circuit safety device configured to detect safe power conditions in the energy-storage module and break an electrical circuit within the energy-storage module based on a detection of unsafe power conditions in the energy-storage module, and a switch configured to selectively couple the energy-storage device to the power bus. The controller is configured to monitor a state of each of the plurality of energy-storage modules and control a state of the power system based on the state of each of the plurality of energy-storage modules.

Abstract: The disclosure provides a CD169 high affinity anti-tumor compound (TCC-Neu5A) and its preparation and application. The CD169 high affinity anti-tumor compound is a small molecule compound, which has specific and broad-spectrum tumor killing characteristics. TCC-Neu5Ac could targets tumor cells in vivo and metabolize onto a surface of the tumor cells to form CD169 ligands. These tumor cells are recognized and phagocytized by CD169-positive macrophages, which then release tumor-related antigens and present them to other immune cells, triggering an anti-tumor immune response. The CD169 high affinity anti-tumor compound provided by the disclosure is effective for a variety of tumors and has an inhibitory effect on tumor metastasis. In addition, the CD169 high affinity anti-tumor compound provided by the disclosure can not only be injected but also be orally administered. Cytotoxicity and animal toxicity of the CD169 high affinity anti-tumor compound are very low.

Abstract: The present disclosure discloses carbohydrate derivatives used for surface modification of immune cells, use thereof, and method thereof. The carbohydrate derivatives are 9-carbon monosaccharide sialic acid derivatives modified at C9 position by targeting substituents. The surfaces of the immune cells (T cells, NK cells, macrophages, DC cells, B cells, or granulocytes) is modified by the carbohydrate derivatives to obtain modified immune cells, so that the modified immune cells can be used for treatment of tumors or other diseases to obtain good effects.

Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.

Abstract: In one aspect, a power system comprises a power bus, a plurality of energy-storage modules, and a controller. Each energy-storage module is coupled to the power bus and comprises an energy-storage device configured to store energy, an electrical circuit safety device configured to detect safe power conditions in the energy-storage module and break an electrical circuit within the energy-storage module based on a detection of unsafe power conditions in the energy-storage module, and a switch configured to selectively couple the energy-storage device to the power bus. The controller is configured to monitor a state of each of the plurality of energy-storage modules and control a state of the power system based on the state of each of the plurality of energy-storage modules.

Abstract: An invisible laser system and an optical path visualization method thereof are disclosed. The invisible laser system comprises an invisible laser light generator for generating invisible laser light; a visible light generator for generating visible light; and an optical path visualization component arranged in optical paths of the invisible and visible light, and comprising a first and second incident end and a first outgoing end. The invisible laser light is incident on the first incident end, and the visible light is incident on the second incident end. All of the invisible laser light and at least part of the visible light are emitted in parallel with each other at the first outgoing end. All of the invisible laser light is present in a direction parallel with the optical path of the visible light, and no invisible laser light is present in other directions, so radiation risks are eliminated.

Abstract: Systems and methods for monitoring and controlling a battery are disclosed. Systems can include a battery having an output voltage and an output current when delivering power, a load driven by power delivered from the battery, battery output voltage and current sensing circuits, and processing circuitry coupled to the battery output voltage and current sensing circuits. The processing circuitry may implement a recurrent neural network for battery state estimation.

Abstract: An imaging apparatus and a positioning apparatus that include an imaging unit for imaging a detected part of a body to be detected; and a distance positioning unit having at least two signal positioning devices, i.e., a signal generator and a signal detector, wherein one signal positioning device is arranged at the detected part, the other signal positioning device is arranged at a position where a predetermined position relationship exists relative to the imaging unit. The position of the detected part in at least one direction in a three-dimensional space relative to the imaging unit is obtained according to a measured distance between the two signal positioning devices. The imaging apparatus and the positioning apparatus reduce pre-positioning imaging sequence workload, and the risk of radiation on the body to be detected is avoided.

Abstract: In a method for acquiring MR diffusion data, in a control computer of an MRI system, multiple individual data sets, respectively corresponding to multiple diffusion models, are defined and combined to form a combined data set. Each of said individual data sets is comprised of multiple diffusion image individual data subsets that are to be acquired on one or more specific shells, respectively, and in one or more gradient directions, respectively. Different specific shells among the multiple shells have different diffusion factors. The control computer then operates the MRI system, namely the data acquisition scanner thereof, in order to acquire MR data corresponding to the defined combined data set.

Abstract: Systems and methods for monitoring and controlling a battery are disclosed. Systems can include a battery having an output voltage and an output current when delivering power, a load driven by power delivered from the battery, battery output voltage and current sensing circuits, and processing circuitry coupled to the battery output voltage and current sensing circuits. The processing circuitry may implement a recurrent neural network for battery state estimation.

Abstract: A patient table includes a table body configured for bearing a patient, a connecting rod structure configured for supporting the table body, and a spring structure. The connecting rod structure is operable such that the table body may perform a lifting motion between a high position and a low position. Both ends of the spring structure are fixed. At least a first end of the spring structure is hinged to the connecting rod structure. The spring structure may be used for driving the lifting motion of the connecting rod structure and/or bearing the table body. The patient table may be used for nuclear magnetic resonance imaging equipment.

Abstract: An invisible laser system and an optical path visualization method thereof are disclosed. The invisible laser system comprises an invisible laser light generator for generating invisible laser light; a visible light generator for generating visible light; and an optical path visualization component arranged in optical paths of the invisible and visible light, and comprising a first and second incident end and a first outgoing end. The invisible laser light is incident on the first incident end, and the visible light is incident on the second incident end. All of the invisible laser light and at least part of the visible light are emitted in parallel with each other at the first outgoing end. All of the invisible laser light is present in a direction parallel with the optical path of the visible light, and no invisible laser light is present in other directions, so radiation risks are eliminated.