Abstract: Use of a soybean protein phosphatase family gene GmPP2C11 is provided. A soybean gene GmPP2C11 encoding a GmPP2C11 protein has the nucleotide sequence of SEQ ID NO: 1. A PSCM-GmPP2C11 knockout vector is genetically transformed into soybean, and it is found that a resulting gene-edited material shows significantly higher hundred-seed weight and yield per plant than those of a receptor Jack. This indicates that the soybean gene GmPP2C11 encoding the soybean GmPP2C11 protein may increase the seed weight and yield of a plant through genetic engineering, thereby providing technical services for increasing the yield of crops, especially soybean.

Abstract: The present disclosure relates to methods and compounds for reprogramming metabolism in one specific retinal and neuronal cell type leading to improved cell and tissue survival and function. In particular, the present disclosure relates to increasing PGC1?/Pgc1? or NRF2/Nrf2 or inhibiting HIF/Hif or KEAP1/Keap1 to reprogram metabolism and survival of cells in a variety of neurodegenerative conditions, and specifically those which cause blindness.

Abstract: The present disclosure relates to methods and compounds for promoting anabolic pathways in neuronal cells leading to improved neuronal survival. In particular, the present disclosure relates to inhibiting PHD to promote glycolysis and neuronal survival in a variety of neurodegenerative conditions such as retinitis pigmentosa.

Abstract: The present disclosure relates to methods and compounds for promoting anabolic pathways in neuronal cells leading to improved neuronal survival. In particular, the present disclosure relates to inhibiting YHL/Vhl to promote glycolysis and neuronal survival in a variety of neurodegenerative conditions, and specifically in retinitis pigmentosa.