Abstract: The present disclosure relates to methods and compounds for reprogramming metabolism in one specific retinal and neuronal cell type leading to improved cell and tissue survival and function. In particular, the present disclosure relates to increasing PGC1?/Pgc1? or NRF2/Nrf2 or inhibiting HIF/Hif or KEAP1/Keap1 to reprogram metabolism and survival of cells in a variety of neurodegenerative conditions, and specifically those which cause blindness.

Abstract: The present disclosure relates to methods and compounds for promoting anabolic pathways in neuronal cells leading to improved neuronal survival. In particular, the present disclosure relates to inhibiting PHD to promote glycolysis and neuronal survival in a variety of neurodegenerative conditions such as retinitis pigmentosa.

Abstract: A non-transitory computer readable medium embodies instructions that cause one or more processors to perform a method. The method includes selecting a 3D model corresponding to an object, and generating a first 2D image of the 3D model in a first pose. The method further includes generating a second 2D image of the 3D model in the first pose, the second 2D image having a different texture on the 3D model than the first 2D image. The method further includes, using an algorithm, determining a first location of a first feature on the 3D model in the first 2D image and a second location of a second feature on the 3D model in the second 2D image. The method further includes calculating a difference based on the first location and the second location. The method further includes adjusting parameters representing the algorithm based on the calculated difference.

Abstract: A non-transitory computer readable medium embodies instructions that cause one or more processors to perform a method. The method includes selecting a 3D model corresponding to an object, and generating a first 2D image of the 3D model in a first pose. The method further includes generating a second 2D image of the 3D model in the first pose, the second 2D image having a different texture on the 3D model than the first 2D image. The method further includes, using an algorithm, determining a first location of a first feature on the 3D model in the first 2D image and a second location of a second feature on the 3D model in the second 2D image. The method further includes calculating a difference based on the first location and the second location. The method further includes adjusting parameters representing the algorithm based on the calculated difference.

Abstract: The present disclosure relates to methods and compounds for promoting anabolic pathways in neuronal cells leading to improved neuronal survival. In particular, the present disclosure relates to inhibiting YHL/Vhl to promote glycolysis and neuronal survival in a variety of neurodegenerative conditions, and specifically in retinitis pigmentosa.

Abstract: A method for setting boot parameters includes: controlling a display to display an input box when detecting a boot setting signal in response to user operation; receiving boot parameters input by the user from the input box; converting the boot parameters input by the user to corresponding ASCII codes, combining the ASCII codes with an identifier identifying the boot parameter to form a data segment, and storing the data segment into the CMOS RAM; reading the ASCII codes from the CMOS RAM when detecting the identifier; setting the boot parameters according to the ASCII codes, and storing the set boot parameters into the BIOS memory.