Abstract: The invention relates to an escapement device for a mechanical timepiece comprising an escapement wheel cooperating with a rocker and a mobile element, the rocker cooperates with the escapement wheel by blocking means and with the balance plate by release means, the mobile element comprises elastic means and cooperates with the teeth of the escapement wheel by winding means and with the balance wheel plate by impulse means, this space-saving escapement device is able to supply the balance wheel with an almost constant quantity of energy within a variable barrel torque range.

Abstract: A method of synthesizing and a method of curing cancers using a nano device are disclosed, the nano device comprising: a framework comprising a structure formed by Si—O—Si covalent bonds and a plurality of mesopores configured to store drug cargos therein by disulfide covalent bonds; and an independent and separate chitosan layer, deposited directly on the framework. The chitosan layer is designed to coat and protect said framework layer from leaking the drug cargos in a first condition and to degrade so as to expose the drug cargos in a second condition. The framework releases the drug cargos by allowing a predetermined concentration of glutathione to break the disulfide (S—S) covalent bonds.

Abstract: The application discloses a method for obtaining MSC-derived cells with improved transplantation properties from MSC, the method comprising a cell size reduction step, wherein said cell size reduction step is characterized by contacting MSC or MSC-derived cells in vitro or ex vivo with heparin or a derivative or analogue thereof at a concentration of at least 0.01 IU/ml. The application further provides a method for obtaining mesenchymal stem cell-derived cells from mesenchymal stem cells (MSC) comprising contacting MSC in vitro or ex vivo with FGF-2, TGF? and at least 0.01 IU/ml heparin or a derivative or analogue thereof. The invention also provides the so-obtained cells and cell populations, as well as further products comprising such and uses thereof.

Abstract: The application discloses a method for obtaining MSC-derived cells with improved transplantation properties from MSC, the method comprising a cell size reduction step, wherein said cell size reduction step is characterized by contacting MSC or MSC-derived cells in vitro or ex vivo with heparin or a derivative or analogue thereof at a concentration of at least 0.01 IU/ml. The application further provides a method for obtaining mesenchymal stem cell-derived cells from mesenchymal stem cells (MSC) comprising contacting MSC in vitro or ex vivo with FGF-2, TGF? and at least 0.01 IU/ml heparin or a derivative or analogue thereof. The invention also provides the so-obtained cells and cell populations, as well as further products comprising such and uses thereof.

Abstract: Methods, systems, and apparatus that detect computing device inputs by a pointing body are disclosed. One method includes detecting user inputs based on a received set of physical touches of a pointing body pressing an operation surface of a computing device indicating a pressed state of the operation surface detected by a pressure sensor, detecting a make event comprising a first physical touch including a first pressure value that is greater than or equal to a make threshold pressure value based on the detected user inputs, and utilizing a first threshold as the make threshold for use in detecting a first round of the make event and a second threshold, which is less than the first threshold, as the make threshold for use in detecting subsequent rounds of the make event within a first predetermined multi-click detection period of time. Systems and apparatus for performing the method are also disclosed.

Abstract: The invention relates to an escapement device (400) comprising a first escapement wheel (1), a second escapement wheel (2), and a brake-lever (3), said second escapement wheel being disposed between the first escapement wheel and the brake-lever, in particular the second escapement wheel coming into contact and engaging with both the first escapement wheel and the brake-lever.

Abstract: Methods, systems, and apparatus that detect computing device inputs by a pointing body are disclosed. One method includes detecting user inputs based on a received set of physical touches of a pointing body pressing an operation surface of a computing device indicating a pressed state of the operation surface detected by a pressure sensor, detecting a make event comprising a first physical touch including a first pressure value that is greater than or equal to a make threshold pressure value based on the detected user inputs, and utilizing a first threshold as the make threshold for use in detecting a first round of the make event and a second threshold, which is less than the first threshold, as the make threshold for use in detecting subsequent rounds of the make event within a first predetermined multi-click detection period of time. Systems and apparatus for performing the method are also disclosed.

Abstract: An appliance to foam a liquid for consumption, the appliance comprising: a container mounting portion to mount thereto a container to contain said liquid; an agitation system configured to foam said liquid, said system comprising a stator arranged external a mounted container, said stator configured to generate a rotating magnetic field for transmission of torque to rotate a rotary agitator arranged in a mounted container, wherein said stator comprises at a circuit board with electrically conductive portions formed thereon.

Abstract: The application discloses a method for obtaining MSC-derived cells with improved transplantation properties from MSC, the method comprising a cell size reduction step, wherein said cell size reduction step is characterized by contacting MSC or MSC-derived cells in vitro or ex vivo with heparin or a derivative or analogue thereof at a concentration of at least 0.01 IU/ml. The application further provides a method for obtaining mesenchymal stem cell-derived cells from mesenchymal stem cells (MSC) comprising contacting MSC in vitro or ex vivo with FGF-2, TGF? and at least 0.01 IU/ml heparin or a derivative or analogue thereof. The invention also provides the so-obtained cells and cell populations, as well as further products comprising such and uses thereof.

Abstract: A stator operable to generate a rotating magnetic field for an electrical rotating machine, the stator comprising at least one circuit board with electrically conductive portions formed thereon, the electrically conductive portions connected with a multiphase configuration, wherein a phase comprises: on a first face of the circuit board(s) electrically conductive portions arranged as a plurality of elements, an element comprising a radially extending radial portion having: connected at a proximal end thereof a proximal portion, the proximal portion extending therefrom with a directional component in a first angular direction; and connected at a distal end thereof a distal portion, the distal portion extending therefrom with a directional component in a second opposed angular direction, whereby proximal and distal are defined relative the centre of rotation of the magnetic field and said angular direction is defined about said centre of rotation; and on a second face of the circuit board(s) electrically conduc

Abstract: An indentation tool includes an installation axis, a radially oriented indentation axis, and a defined reserved space for an indentation site of a cylindrically-shaped structure, as well as a base for installing onto the structure, and an elongate punch for indenting it at its indentation site. The reserved space is spaced apart from the installation axis, and has the indentation axis passing through it. The base extends along the installation axis, and is configured for coaxial installation onto the structure, whereby its indentation site occupies the reserved space. The punch is spaced apart from the installation axis, and is supported by the base for movement along the indentation axis between a home position, in which the punch vacates the reserved space, and an indentation position, in which the punch, leading with an indentation tip, reaches into the reserved space to indent the structure at its indentation site.

Abstract: The invention relates to an escapement device (400) comprising a first escapement wheel (1), a second escapement wheel (2), and a brake-lever (3), said second escapement wheel being disposed between the first escapement wheel and the brake-lever, in particular the second escapement wheel coming into contact and engaging with both the first escapement wheel and the brake-lever.

Abstract: An indentation tool includes an installation axis, a radially oriented indentation axis, and a defined reserved space for an indentation site of a cylindrically-shaped structure, as well as a base for installing onto the structure, and an elongate punch for indenting it at its indentation site. The reserved space is spaced apart from the installation axis, and has the indentation axis passing through it. The base extends along the installation axis, and is configured for coaxial installation onto the structure, whereby its indentation site occupies the reserved space. The punch is spaced apart from the installation axis, and is supported by the base for movement along the indentation axis between a home position, in which the punch vacates the reserved space, and an indentation position, in which the punch, leading with an indentation tip, reaches into the reserved space to indent the structure at its indentation site.

Abstract: A stator operable to generate a rotating magnetic field for an electrical rotating machine, the stator comprising at least one circuit board with electrically conductive portions formed thereon, the electrically conductive portions connected with a multiphase configuration, wherein a phase comprises: on a first face of the circuit board(s) electrically conductive portions arranged as a plurality of elements, an element comprising a radially extending radial portion having: connected at a proximal end thereof a proximal portion, the proximal portion extending therefrom with a directional component in a first angular direction; and connected at a distal end thereof a distal portion, the distal portion extending therefrom with a directional component in a second opposed angular direction, whereby proximal and distal are defined relative the centre of rotation of the magnetic field and said angular direction is defined about said centre of rotation; and on a second face of the circuit board(s) electrically conduc

Abstract: An appliance to foam a liquid for consumption, the appliance comprising: a container mounting portion to mount thereto a container to contain said liquid; an agitation system configured to foam said liquid, said system comprising a stator arranged external a mounted container, said stator configured to generate a rotating magnetic field for transmission of torque to rotate a rotary agitator arranged in a mounted container, wherein said stator comprises at a circuit board with electrically conductive portions formed thereon.

Abstract: The invention relates to a timepiece fitted with a lever escapement wherein the end of contact angles ?1 and ?2 between the pallet stones and the escapement wheel are respectively higher than the locking-angles ?2 and ?1 of the two locking positions of the lever. This escapement requires neither adjustment nor final alteration of the position of the pallet stones.

Abstract: The invention relates to a timepiece fitted with a lever escapement wherein the end of contact angles ?1 and ?2 between the pallet stones and the escapement wheel are respectively higher than the locking-angles ?2 and ?1 of the two locking positions of the lever. This escapement requires neither adjustment nor final alteration of the position of the pallet stones.

Abstract: Escapement device of a timepiece movement includes an escapement wheel, a first mobile having means of locking with the escapement wheel and of mechanical transmission with the escapement wheel, a second mobile and the balance roller. The second mobile has means of locking with the escapement wheel and means of mechanical transmission with the escapement wheel and the first mobile. The mobiles are driven by the escapement wheel tangentially.

Abstract: Escapement device of a timepiece movement includes an escapement wheel, a first mobile having means of locking with the escapement wheel and of mechanical transmission with the escapement wheel, a second mobile and the balance roller. The second mobile has means of locking with the escapement wheel and means of mechanical transmission with the escapement wheel and the first mobile. The mobiles are driven by the escapement wheel tangentially.

Abstract: The present invention relates to uses of growth and differentiation factor 8 (GDF-8) in vitro or in vivo for reducing the immunogenicity or risk of rejection of cells such as in particular mesenchymal stem cells (MSC), tissues or materials. The present invention further relates to methods for differentiating MSC in vitro or ex vivo into osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells using FGF-2 and GDF-8. In addition, the present invention relates to osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells obtainable by such methods and to the osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells for use in the treatment of musculoskeletal diseases.