Patents by Inventor Xuanxuan GUO

Xuanxuan GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220177524
    Abstract: Provided are a method of producing a modified T cell comprising introducing into a precursor T cell a first nucleic acid encoding a Nef protein, wherein the Nef protein upon expression results in down-modulation of the endogenous T cell receptor (TCR) in the modified T cell, wherein the modified T cell furthermore expresses a functional exogenous receptor, such as an engineered TCR (e.g., chimeric TCR), T cell antigen coupler (TAC), TAC-like chimeric receptor, or a chimeric antigen receptor (CAR), the modified cell obtained by the method and the pharmaceutical composition comprising the modified T cell. Also provided is a non-naturally occurring Nef protein comprising one or more mutations.
    Type: Application
    Filed: July 26, 2019
    Publication date: June 9, 2022
    Inventors: Xiaohu FAN, Yuncheng ZHAO, Dawei YU, Wujinan ZHI, Chenchen WANG, Qiuchuan ZHUANG, Pingyan WANG, Xuanxuan GUO