Patents by Inventor Xuanyi MA

Xuanyi MA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for fabrication of microwells for controlled formation of 3-dimensional multicellular-shapes
    Patent number: 10351819
    Abstract: Using 3D printing, a microwell is formed by providing a plurality of masks, each mask representing a cross-section of a layer of the concave structure. Progressive movement of a projection plane exposes a pre-polymer solution to polymerizing radiation modulated by the masks to define the layers of the microwell, where each layer is exposed for a non-equal exposure period as determined by a non-linear factor. In a preferred embodiment, a first portion of the masks are base layer masks, which are exposed for a longer period than subsequent exposure periods. Shapes of the microwells, which may include circular, square, annular, or other geometric shapes, and their depths, are selected to promote aggregation behavior in the target cells, which may include tumor cells and stem cells.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: July 16, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Kolin C. Hribar, Shaochen Chen, Darren Finlay, Kristiina Vuori, Xuanyi Ma
  • METHOD FOR FABRICATION OF MICROWELLS FOR CONTROLLED FORMATION OF 3-DIMENSIONAL MULTICELLULAR-SHAPES
    Publication number: 20170283766
    Abstract: Using 3D printing, a microwell is formed by providing a plurality of masks, each mask representing a cross-section of a layer of the concave structure. Progressive movement of a projection plane exposes a pre-polymer solution to polymerizing radiation modulated by the masks to define the layers of the microwell, where each layer is exposed for a non-equal exposure period as determined by a non-linear factor. In a preferred embodiment, a first portion of the masks are base layer masks, which are exposed for a longer period than subsequent exposure periods. Shapes of the microwells, which may include circular, square, annular, or other geometric shapes, and their depths, are selected to promote aggregation behavior in the target cells, which may include tumor cells and stem cells.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 5, 2017
    Inventors: Kolin C. HRIBAR, Shaochen CHEN, Darren FINLAY, Kristiina VUORI, Xuanyi MA
  • Materials and methods for filling biological cavities and preventing leakage of injected therapeutic agents
    Patent number: 9307968
    Abstract: The subject invention pertains to medical apparatuses and methods for reducing or preventing leakage of injected therapeutic agents (including liquid-containing substances, cells) into a solid or hollow tissue/organ after puncturing.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: April 12, 2016
    Assignee: The University of Hong Kong
    Inventors: Barbara Pui Chan, Tsz Kit Chik, Tsz Hang Andrew Choy, Xuanyi Ma, K. M. C. Cheung
  • MATERIALS AND METHODS FOR FILLING BIOLOGICAL CAVITIES AND PREVENTING LEAKAGE OF INJECTED THERAPEUTIC AGENTS
    Publication number: 20130338636
    Abstract: The subject invention pertains to medical apparatuses and methods for reducing or preventing leakage of injected therapeutic agents (including liquid-containing substances, cells) into a solid or hollow tissue/organ after puncturing.
    Type: Application
    Filed: June 13, 2013
    Publication date: December 19, 2013
    Applicant: THE UNIVERSITY OF HONG KONG
    Inventors: Barbara Pui CHAN, Tsz Kit CHIK, Tsz Hang Andrew CHOY, Xuanyi MA, K.M.C. CHEUNG