Patents by Inventor Xubo Yuan

Xubo Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12298280
    Abstract: The present disclosure provides a method for increasing a number of proteins identified, including: S1. adding a binding buffer and an aluminosilicate zeolite to a sample to be tested to obtain a first suspension; S2. incubating the first suspension, subjecting an incubated first suspension to first high-speed centrifugation to obtain a first supernatant and a first precipitate, discarding the first supernatant, and retaining the first precipitate; S3. repeating a process as follows several times: resuspending the first precipitate with a washing buffer to obtain a second suspension, subjecting the second suspension to second high-speed centrifugation to obtain a second supernatant and a second precipitate, discarding the second supernatant, and retaining the second precipitate; and S4. preparing the second precipitate into a protein sample, and subjecting the protein sample to mass spectrometry detection.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: May 13, 2025
    Assignee: PROTEINT (TIANJIN) BIOTECHNOLOGY CO., LTD
    Inventors: Congcong Ma, Jin Zhao, Xubo Yuan, Liangyu Chen, Lei Song, Li Ren, Jie Li
  • Publication number: 20240264128
    Abstract: The present disclosure provides a method for increasing a number of proteins and/or peptides identified, including: S1. adding a binding buffer and an aluminosilicate zeolite to a sample to be tested to obtain a first suspension; S2. incubating the first suspension, subjecting an incubated first suspension to first high-speed centrifugation to obtain a first supernatant and a first precipitate, discarding the first supernatant, and retaining the first precipitate; S3. repeating a process as follows several times: resuspending the first precipitate with a washing buffer to obtain a second suspension, subjecting the second suspension to second high-speed centrifugation to obtain a second supernatant and a second precipitate, discarding the second supernatant, and retaining the second precipitate; and S4. preparing the second precipitate into a protein sample, and subjecting the protein sample to mass spectrometry detection.
    Type: Application
    Filed: October 27, 2021
    Publication date: August 8, 2024
    Applicant: PROTEINT (TIANJIN) BIOTECHNOLOGY CO., LTD
    Inventors: Congcong MA, Jin ZHAO, Xubo YUAN, Liangyu CHEN, Lei SONG, Li REN, Jie LI
  • Publication number: 20210169817
    Abstract: Disclosed is a tumour therapeutic monoclonal antibody nano-capsule, i.e. a nano-capsule which is prepared by the polymerization of poly 2-methacryloyloxyethyl phosphorylcholine and nimotuzumab, has a round and smooth surface, a uniform particle size and a tumour targeting delivery effect. It has inhibitory effect on proliferation of a tumour, in particular glioma and gastric tumours. The preparation method is taking 0.1-100 mg nimotuzumab solution, adding a monomer having a carbon-carbon double bond, a crosslinker and an initiator respectively according to the molar ratio of the nimotuzumab solution and the monomer having a carbon-carbon double bond, the crosslinker and the initiator of 1:100-1:100000, 1:100-1:10000, 1:100-1:10000 and obtaining the desired product by the method of in situ polymerization.
    Type: Application
    Filed: February 28, 2017
    Publication date: June 10, 2021
    Inventors: Xubo YUAN, Chunsheng KANG, Yunfeng LU
  • Publication number: 20200323786
    Abstract: Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited in by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.
    Type: Application
    Filed: May 24, 2017
    Publication date: October 15, 2020
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNIVERSITY OF SOUTHERN CALIFORNIA, TIANJIN UNIVERSITY
    Inventors: Yunfeng Lu, Jeffrey C. Wang, Haijun Tian, Juanjuan Du, Jing Wen, Yang Liu, Xubo Yuan