Patents by Inventor Xuchao Li
Xuchao Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11761037Abstract: The present invention discloses a probe applicable to high-throughput sequencing and a method of enriching a target region using the probe. The probe includes, in an order from a 5? end, a ligation arm, a masking sequence 1, a UID sequence 1, an Illumina Tag1 sequence, a dU region, an Illumina Tag2 sequence, a UID sequence 2, a masking sequence 2 and an extension arm; wherein the masking sequence 1, the masking sequence 2, the dU region, the UID sequence 1, and the UID sequence 2 may be 0 bp. When sequencing is performed by using a library built by the probe of the present invention, it is not necessary to add a sequencing primer additionally, and adopting the method of the present invention may directly use an RNA as a template to capture a target region, so as to simplify the experiment procedure.Type: GrantFiled: July 18, 2018Date of Patent: September 19, 2023Assignee: AMOY DIAGNOSTICS CO., LTD.Inventors: Linhua Zhang, Xuchao Li, Huijuan Ge, Baolei Jin, Ning Chen, Li Ruan, Limou Zheng
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Patent number: 11371074Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.Type: GrantFiled: January 29, 2018Date of Patent: June 28, 2022Assignee: BGI Genomics Co., Ltd.Inventors: Xuchao Li, Shengpei Chen, Fang Chen, Weiwei Xie, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Patent number: 11286524Abstract: A multi-position double-tag adapter set for detecting gene mutation and preparation method therefor and application thereof, the multi-position double-tag adapter set comprising a double-tag adapter A, a double-tag adapter B and a double-tag adapter C. The double-tag adapter A, the double-tag adapter B and the double-tag adapter C are obtained respectively by hybridizing an adapter primer P5 with an adapter primer P7-A, an adapter primer P7-B and an adapter primer P7-C 5? ends of which are all modified with biotin. Using the multi-position double-tag adapter set, the mutation rate of 1×10?5 genes may be accurately detected and the sensitivity of gene mutation detection may be effectively improved. A plurality of mutation sites of a plurality of genes may be detected by one-time sequencing in combination with throughput of high-throughput sequencing.Type: GrantFiled: August 28, 2017Date of Patent: March 29, 2022Assignee: Amoy Diagnostics Co., Ltd.Inventors: Baolei Jin, Xuchao Li, Qinghua Lin, Weijie Shi, Huijuan Ge, Li Ruan
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Patent number: 11227948Abstract: A lateral double-diffused metal oxide semiconductor component and a manufacturing method therefor. The lateral double-diffused metal oxide semiconductor component comprises: a semiconductor substrate, the semiconductor substrate being provided thereon with a drift area; the drift area being provided therein with a trap area and a drain area, the trap area being provided therein with an active area and a channel; the drift area being provided therein with a deep trench isolation structure arranged between the trap area and the drain area, and the deep trench isolation structure being provided at the bottom thereof with alternately arranged first p-type injection areas and first n-type injection areas.Type: GrantFiled: September 1, 2018Date of Patent: January 18, 2022Assignee: CSMC TECHNOLOGIES FAB2 CO., LTD.Inventors: Nailong He, Sen Zhang, Xuchao Li
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Publication number: 20210036150Abstract: A lateral double-diffused metal oxide semiconductor component and a manufacturing method therefor. The lateral double-diffused metal oxide semiconductor component comprises: a semiconductor substrate, the semiconductor substrate being provided thereon with a drift area; the drift area being provided therein with a trap area and a drain area, the trap area being provided therein with an active area and a channel; the drift area being provided therein with a deep trench isolation structure arranged between the trap area and the drain area, and the deep trench isolation structure being provided at the bottom thereof with alternately arranged first p-type injection areas and first n-type injection areas.Type: ApplicationFiled: September 1, 2018Publication date: February 4, 2021Applicant: CSMC Technologies FAB2 Co., Ltd.Inventors: Nailong HE, Sen ZHANG, Xuchao LI
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Publication number: 20200010892Abstract: A multi-position double-tag connector set for detecting gene mutation and preparation method therefor and application thereof, the multi-position double-tag connector set comprising a double-tag connector A, a double-tag connector B and a double-tag connector C. The double-tag connector A, the double-tag connector B and the double-tag connector C are obtained respectively by means of synthesizing a connector primer P5 with a connector primer P7-A, a connector primer P7-B and a connector primer P7-C of 5? ends which are all modified with biotin. Using the multi-position double-tag connector set, the mutation rate of 1×10?5 genes may be accurately detected and the sensitivity of gene mutation detection may be effectively improved. A plurality of mutation sites of a plurality of genes may be detected by one-time sequencing in combination with throughput of high-throughput sequencing.Type: ApplicationFiled: August 28, 2017Publication date: January 9, 2020Applicant: Amoy Diagnostics Co., Ltd.Inventors: Baolei JIN, Xuchao LI, Qinghua LIN, Weijie SHI, Huijuan GE, Li RUAN
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Publication number: 20180371539Abstract: Disclosed are a method of detecting a pre-determined event in a nucleic acid sample and a system thereof. The method of detecting the pre-determined event in the nucleic acid sample comprises the following steps: constructing a sequencing-library for the nucleic acid sample; sequencing the sequencing-library to obtain a sequencing result consisting of a plurality of sequencing data; determining the sequencing data from a pre-determined region; and determining an occurrence of the pre-determined event in the nucleic acid sample based on a composition of the sequencing data from the pre-determined region.Type: ApplicationFiled: June 29, 2018Publication date: December 27, 2018Inventors: Hui Jiang, Fang Chen, Huijuan Ge, Peipei Li, Xuchao Li, Jian Wang, Jun Wang, Huanming Yang
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Publication number: 20180320235Abstract: Provided are a method, system and computer readable medium for determining the base information in a predetermined area of a fetus genome, the method comprising following steps: constructing a sequence library for the DNA samples of the fetus genome; sequencing the sequence library to obtain the sequencing result of the fetus, the sequencing result of the fetus comprised of a plurality of sequencing data; and based on the sequencing result of the fetus, determining the base information in the predetermined area according to the hidden Markov model in conjunction with the genetic information of an individual related hereditarily to the fetus.Type: ApplicationFiled: July 19, 2018Publication date: November 8, 2018Inventors: Shengpei Chen, Huijuan Ge, Xuchao Li, Shang Yi, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20180148765Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.Type: ApplicationFiled: January 29, 2018Publication date: May 31, 2018Inventors: Xuchao LI, Shengpei CHEN, Fang CHEN, Weiwei XIE, Jian WANG, Jun WANG, Huanming YANG, Xiuqing ZHANG
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Publication number: 20150105264Abstract: Provided are a method and a system for identifying whether the twins are dizygotic twins, the method comprising: typing at least one polymorphic loci of the twins fetuses to obtain the fetal polymorphism types, comparing the fetal polymorphism types with the corresponding polymorphism types of their parents, determining whether the twins are dizygotic twins on the basis of the comparison result.Type: ApplicationFiled: May 23, 2012Publication date: April 16, 2015Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Huijuan Ge, Jing Zheng, Shang Yi, Xuchao Li, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20150094210Abstract: Provided are a method, system and computer readable medium for determining the base information in a predetermined area of a fetus genome, the method comprising following steps: constructing a sequence library for the DNA samples of the fetus genome; sequencing the sequence library to obtain the sequencing result of the fetus, the sequencing result of the fetus comprised of a plurality of sequencing data; and based on the sequencing result of the fetus, determining the base information in the predetermined area according to the hidden Markov model in conjunction with the genetic information of an individual related hereditarily to the fetus.Type: ApplicationFiled: May 14, 2012Publication date: April 2, 2015Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Shengpei Chen, Huijuan Ge, Xuchao Li, Shang Yi, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20150056619Abstract: Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method comprises obtaining reads; determining sequence labels according to the reads; counting the number of sequence labels falling into each window; performing GC correction on the sequence label number of each window and a correction according to an expected sequence label number adjusted by a control set to obtain a corrected sequence label number; selecting a demarcation point with a small significance value as a candidate CNV breaking point; rejecting the least significant candidate CNV breaking point at every turn, updating difference significance values of two candidate CNV breaking points on the left and right of the rejected candidate CNV breaking point and performing cyclic iteration until difference significance values of all candidate CNV breaking points are smaller than a termination threshold value, thereby determining a CNV breaking point.Type: ApplicationFiled: April 5, 2012Publication date: February 26, 2015Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Xuchao Li, Shengpei Chen, Fang Chen, Weiwei Xie, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang
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Publication number: 20140274745Abstract: The present invention relates to the field of genomic mutation detection, and in particular, to the detection of the copy number variation (CNV) in cellular chromosomal DNA fragments. The present invention also relates to the detection of diseases related to the copy number variation in the cellular chromosomal DNA fragments.Type: ApplicationFiled: October 28, 2011Publication date: September 18, 2014Applicant: BGI DIAGNOSIS CO., LTD.Inventors: Fang Chen, Xiaoyu Pan, Shengpei Chen, Xuchao Li, Hui Jiang, Xiuqing Zhang
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Publication number: 20140249038Abstract: Disclosed are a method of detecting a pre-determined event in a nucleic acid sample and a system thereof. The method of detecting the pre-determined event in the nucleic acid sample comprises the following steps: constructing a sequencing-library for the nucleic acid sample; sequencing the sequencing-library to obtain a sequencing result consisting of a plurality of sequencing data; determining the sequencing data from a pre-determined region; and determining an occurrence of the pre-determined event in the nucleic acid sample based on a composition of the sequencing data from the pre-determined region.Type: ApplicationFiled: December 21, 2011Publication date: September 4, 2014Applicant: BGI Diagnosis Co., LtdInventors: Hui Jiang, Fang Chen, Huijuan Ge, Peipei Li, Xuchao Li, Jian Wang, Jun Wang, Huanming Yang, Xiuqing Zhang