Patents by Inventor Xue Zhen
Xue Zhen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11923419Abstract: Chemical sensors, devices and systems including the same, and related methods are disclosed. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a ?-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives of each. Other embodiments are also included.Type: GrantFiled: August 18, 2020Date of Patent: March 5, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester
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Patent number: 11867596Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a ?-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.Type: GrantFiled: March 29, 2022Date of Patent: January 9, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester, Justin Theodore Nelson
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Publication number: 20220334075Abstract: Embodiments herein relate to systems and methods for utilizing hysteresis as a mechanism of analysis of a sample. A system for analyzing a fluid sample is included having a controller circuit and a chemical sensor element. The chemical sensor element can include one or more discrete binding detectors that can include one or more graphene varactors. The system can include measurement circuitry having an electrical voltage generator configured to generate an applied voltage at a plurality of voltage values to be applied to the one or more graphene varactors. The system can include a measurement circuit having a capacitance sensor configured to measure capacitance of the discrete binding detectors resulting from the applied voltage. The system for analyzing the fluid sample can be configured to measure hysteresis effects related to capacitance versus voltage values obtained from the one or more graphene varactors. Other embodiments are also included herein.Type: ApplicationFiled: April 13, 2022Publication date: October 20, 2022Inventors: Steven Koester, Qun Su, Philippe Pierre Joseph Buhlmann, Xue Zhen, Justin Theodore Nelson, Gregory J. Sherwood
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Publication number: 20220304589Abstract: Embodiments herein relate to chemical sensors based on the non-covalent surface modification of graphene with compounds containing hydrazine or hydroxylamine functional groups for the detection of aldehyde and ketone-bearing analytes. In an embodiment, a medical device is included having a graphene varactor included a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a ?-electron system of graphene. The self-assembled monolayer can include one or more compounds having one or more hydrazine groups or hydroxylamine groups, substituted hydrazine or hydroxylamine groups, or derivatives thereof. Other embodiments are also included herein.Type: ApplicationFiled: March 8, 2022Publication date: September 29, 2022Inventors: Blair K. Troudt, Philippe Pierre Joseph Buhlmann, Steven Koester, Xue Zhen
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Publication number: 20220291198Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a ?-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.Type: ApplicationFiled: March 29, 2022Publication date: September 15, 2022Inventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester, Justin Theodore Nelson
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Patent number: 11307165Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.Type: GrantFiled: July 20, 2017Date of Patent: April 19, 2022Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Jinbo Hu, Philippe Buhlmann, Andreas Stein, Xue Zhen
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Patent number: 11293914Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.Type: GrantFiled: April 24, 2019Date of Patent: April 5, 2022Assignees: Boston Scientific Scimed, Inc., REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester, Justin Theodore Nelson
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Publication number: 20210369250Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor. The graphene varactor includes a graphene layer and at least one non-covalent modification layer disposed on an outer surface of the graphene layer. The non-covalent modification layer can include nanoparticles selected from a group that can include one or more metals, metal oxides, or derivatives thereof. Other embodiments are also included herein.Type: ApplicationFiled: May 24, 2021Publication date: December 2, 2021Inventors: Philippe Pierre Joseph Buhlmann, Steven J. Koester, Justin Theodore Nelson, Xue Zhen
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Publication number: 20210356457Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through ?-? stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.Type: ApplicationFiled: July 28, 2021Publication date: November 18, 2021Inventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven Koester, Yao Zhang, Justin Theodore Nelson
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Patent number: 11079371Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through ?-? stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.Type: GrantFiled: February 20, 2019Date of Patent: August 3, 2021Assignees: Boston Scientific Scimed, Inc., REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester, Yao Zhang, Justin Theodore Nelson
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Publication number: 20210147238Abstract: Embodiments herein relate to methods and systems for applying a transfer material layer to graphene during a graphene fabrication process. In an embodiment, a method of producing a graphene sensor element is included. The method includes forming a graphene layer on a growth substrate and applying a fluoropolymer coating layer over the graphene layer. The method includes removing the growth substrate and transferring the graphene and fluoropolymer coating layers onto a transfer substrate, where the graphene layer is disposed on the transfer substrate and the fluoropolymer layer is disposed on the graphene layer. The method also includes removing the fluoropolymer coating layer. Other embodiments are also included herein.Type: ApplicationFiled: November 12, 2020Publication date: May 20, 2021Inventors: Steven J. Koester, Xue Zhen, Philippe Pierre Joseph Buhlmann, Qun Su, Justin Theodore Nelson, Gregory J. Sherwood
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Publication number: 20210057526Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a ?-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives thereof. Other embodiments are also included herein.Type: ApplicationFiled: August 18, 2020Publication date: February 25, 2021Inventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester
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Publication number: 20190331661Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.Type: ApplicationFiled: April 24, 2019Publication date: October 31, 2019Inventors: Xue Zhen, Philippe Pierre Joseph Buhlmann, Steven J. Koester, Justin Theodore Nelson
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Publication number: 20180024087Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.Type: ApplicationFiled: July 20, 2017Publication date: January 25, 2018Inventors: Jinbo Hu, Philippe Buhlmann, Andreas Stein, Xue Zhen