Abstract: A brake device and a winch having the same are provided. The brake device includes a brake sleeve, a torsion spring, a sealing member and a braking assembly. The torsion spring is fitted over the braking assembly, and the brake sleeve is fitted over the torsion spring. The braking assembly is configured to drive the torsion spring to move between an expanded position and a retracted position, so as to lock and release the brake sleeve. The sealing member is arranged between the brake sleeve and the braking assembly, so that a sealing cavity is defined between the brake sleeve and the braking assembly.

Abstract: A vehicle winch includes a motor assembly, a rope drum assembly, and a reducing gear assembly. The rope drum assembly defines a drum cavity extending in an axial direction of the rope drum assembly, and a part of the motor assembly is arranged in the drum cavity. The reducing gear assembly includes a primary planet gear train and a reducing gear train subassembly, the motor assembly, the primary planet gear train and the reducing gear train subassembly are sequentially arranged along the axial direction, the primary planet gear train is arranged in the drum cavity, and the primary planet gear train has an input end coupled to an output end of the motor assembly and an output end coupled to an input end of the reducing gear train subassembly, and the reducing gear train subassembly has an output end coupled to an input end of the rope drum assembly.

Abstract: The present disclosure relates to a reducer. The reducer includes a casing, an internal ring gear and an elastic cushion. The casing has an inner circumferential wall provided with a first limiting part. The internal ring gear is arranged in the casing and has an outer circumferential wall provided with a second limiting part. The first limiting part is fitted with the second limiting part to limit rotation of the internal ring gear. The elastic cushion has at least a portion located between the second limiting part and the inner circumferential wall of the casing and abutting against the second limiting part and the inner circumferential wall of the casing.

Abstract: A brake device for a winch and a winch are provided. The winch includes a rope drum, and the brake device includes a brake sleeve, an elastic ring, a torsion spring and a braking assembly. The torsion spring is fitted over the braking assembly, and the brake sleeve is fitted over the torsion spring. The braking assembly is configured to drive the torsion spring to move between an extended position and a retracted position, so as to lock and release the brake sleeve. The elastic ring is fitted over the brake sleeve and configured to abut with an inner wall of the rope drum.

Abstract: A brake device and a winch having the same are provided. The brake device includes a brake sleeve, a torsion spring, a sealing member and a braking assembly. The torsion spring is fitted over the braking assembly, and the brake sleeve is fitted over the torsion spring. The braking assembly is configured to drive the torsion spring to move between an expanded position and a retracted position, so as to lock and release the brake sleeve. The sealing member is arranged between the brake sleeve and the braking assembly, so that a sealing cavity is defined between the brake sleeve and the braking assembly.

Abstract: A drug design method associated with natural products, includes: acquiring a molecular structure of a to-be-modified natural product with a specific biological activity; using the molecular structure as a template molecule, selecting a plurality of natural products as a reference molecule set, where the plurality of natural products has the specific biological activity and a structural similarity thereof to the template molecule is within a threshold range; and selecting one or more reference molecules from the reference molecule set, comparing the one or more reference molecules with the template molecule and determining at least one different active functional group therebetween; and constructing the at least one different active functional group on a molecular scaffold shared by the template molecule and the one or more reference molecules, thereby obtaining a modified molecular structure of the natural product with the specific biological activity.

Abstract: The present invention provides methods and related vectors and host cells for quantitative analysis of protein interactions in eukaryotic expression system. More specifically, the invention provides a yeast surface two-hybrid (YS2H) system that can express a pair of proteins, one protein (“bait”) as a fusion to a yeast cell wall protein, and the other (“prey”) in a secretory form. When two proteins interact in this system, they associate in the secretory pathway, and the prey that would otherwise be released into the media is captured on the cell surface by the bait. Expression of the bait and the prey proteins can be designed to promote a synchronized and comparable level of expression.