Abstract: Provided herein are vaccine composition comprising a bovine leukemia virus (BLV) antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising a BLV antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of BLV infection and associated sequelae, e.g. cancer, immunosuppressive, and inflammatory diseases.

Abstract: Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.

Abstract: The present disclosure relates to disaccharides with defined sulfation patterns, and oligosaccharide mimetics comprising the disaccharides as repeating units linked in a head to tail fashion. The present disclosure further relates to methods of making the same, and to methods of using the same to mediate cell proliferation, cell differentiation, amyloid plaque formation, anti-coagulation, and neuronal growth.

Abstract: A carriage comprises a carriage body (1) consisting of a top frame, side walls, and a bottom frame. An end wall (2) is disposed on at least one end of the carriage body (1). Connectors (3) are symmetrically disposed on the left side and the right side of an outer wall body of the end wall (2). All the connectors (3) disposed on the end wall (2) of the carriage are connected by means of lines. The carriages can be grouped into each train in a meal ordering manner. When each carriage is added into a high-speed train set, the arrangement of the carriage is not limited, and accordingly, the carriage can be added into the train without limitation. On the premise the of ensuring the normal work of systems of the train, the work amount of staff members in a group can be reduced, and the work time of the staff members in the group is shortened.

Abstract: Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.

Abstract: A carriage comprises a carriage body (1) consisting of a top frame, side walls, and a bottom frame. An end wall (2) is disposed on at least one end of the carriage body (1). Connectors (3) are symmetrically disposed on the left side and the right side of an outer wall body of the end wall (2). All the connectors (3) disposed on the end wall (2) of the carriage are connected by means of lines. The carriages can be grouped into each train in a meal ordering manner. When each carriage is added into a high-speed train set, the arrangement of the carriage is not limited, and accordingly, the carriage can be added into the train without limitation. On the premise the of ensuring the normal work of systems of the train, the work amount of staff members in a group can be reduced, and the work time of the staff members in the group is shortened.

Abstract: The present inventions relate to compositions and methods for imaging and treating atherosclerotic diseases, pathogen infections, and tumors by administering actively targeting magnetic nanoparticles. In particular, the present inventions provide new types of targeting ligands attached to magnetic nanoparticles for magnetic resonance imaging. The use of these targeted magnetic nanoparticles is contemplated as a means to treat atherosclerotic diseases, including but not limited to inhibiting and removing atherosclerotic plaques. Further, actively targeting magnetic nanoparticles are contemplated for use with multiple labels for use in nuclear medicine imaging, computed tomography (CT) techniques and other types of imaging for medical and research applications.

Abstract: A method and system for detecting magnetic nanoparticles include measuring a magneto-optical enhancement of the plasmon absorption in the optical response.

Abstract: A method and system for detecting magnetic nanoparticles include measuring a magneto-optical enhancement of the plasmon absorption in the optical response.

Abstract: A process for synthesizing an oligosaccharide includes (a) activating a protected glycosyl donor with a promoter in the absence of a glycosyl acceptor to produce a reactive intermediate, the glycosyl donor having an activatable aglycon at the anomeric carbon; (b) adding a protected glycosyl donor/acceptor to the reactive intermediate to produce a new glycosyl donor, the glycosyl donor/acceptor having both an activatable aglycon at the anomeric carbon and a free hydroxyl group; (c) repeating steps (a) and (b) to add any additional protected glycosyl donor/acceptors; and (d) adding a protected glycosyl acceptor to produce the oligosaccharide, the glycosyl acceptor having a free hydroxyl group and a non-activatable aglycon at the anomeric carbon.