Abstract: The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and easy to synthesize at high yield and purity in just a few steps using commercially available starting materials. The tagging reagents of the present invention comprise: a) a reporter group, having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an aldehyde, ketone, or carboxylic acid reactive group. The multiplex SUGAR tags are able to react with an aldehyde, ketone, or carboxylic acid group of the molecule to be tagged, which offers the capability for labeling and quantitation of glycans, proteins/peptides, and fatty acids.

Abstract: The present invention generally pertains to methods of quantitating therapeutic proteins co-administered to a subject using LC-MRM-MS. In particular, the present invention pertains to the use of dual enzymatic digestion to generate unique surrogate peptides allowing for the accurate quantitation of co-administered therapeutic proteins using LC-MRM-MS.

Abstract: The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and easy to synthesize at high yield and purity in just a few steps using commercially available starting materials. The tagging reagents of the present invention comprise: a) a reporter group, having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an aldehyde, ketone, or carboxylic acid reactive group. The multiplex SUGAR tags are able to react with an aldehyde, ketone, or carboxylic acid group of the molecule to be tagged, which offers the capability for labeling and quantitation of glycans, proteins/peptides, and fatty acids.

Abstract: The present disclosure provides an automatic control system for emission indexes of a desulfurization device of a thermal power unit, which comprises a first controller, a second controller and a flow controller. At the same time, the present disclosure provides an automatic control method for emission indexes of a desulfurization device of a thermal power unit. The present disclosure runs through the production and operation data of waste gas desulfurization treatment facilities, and establishes a pH optimization set value prediction model according to the data, and can realize automatic regulation and control of pH value by optimizing and controlling the pH optimization set value and the slurry flow optimization set value every moment through the dynamic model, thus solving the problem that the pH value control process is large in lag and slow in dynamics, and improving the pH value control quality.

Abstract: The present disclosure provides an automatic control system for emission indexes of a desulfurization device of a thermal power unit, which comprises a first controller, a second controller and a flow controller. At the same time, the present disclosure provides an automatic control method for emission indexes of a desulfurization device of a thermal power unit. The present disclosure runs through the production and operation data of waste gas desulfurization treatment facilities, and establishes a pH optimization set value prediction model according to the data, and can realize automatic regulation and control of pH value by optimizing and controlling the pH optimization set value and the slurry flow optimization set value every moment through the dynamic model, thus solving the problem that the pH value control process is large in lag and slow in dynamics, and improving the pH value control quality.

Abstract: A visible light band reflection metasurface device and a reflected light wavelength modulation method. The device successively includes, from top to bottom, a metal metasurface layer with periodically arranged antenna units, a modulation layer formed by an electro-optic material, a metal reflection layer and a substrate layer; the antenna unit period is less than the incident wavelength, and the thickness is greater than the skin depth of metal and less than 100 nm; the thickness of the modulation layer is less than the wavelength of the incident light; and the thickness of the metal reflection layer is greater than the skin depth of metal and less than the wavelength of the incident light; and an external voltage source can modulate the color of the reflected light, and can achieve voltage modulation of the color of reflected light in the visible light band.

Abstract: A visible light band reflection metasurface device and a reflected light wavelength modulation method. The device successively includes, from top to bottom, a metal metasurface layer with periodically arranged antenna units, a modulation layer formed by an electro-optic material, a metal reflection layer and a substrate layer; the antenna unit period is less than the incident wavelength, and the thickness is greater than the skin depth of metal and less than 100 nm; the thickness of the modulation layer is less than the wavelength of the incident light; and the thickness of the metal reflection layer is greater than the skin depth of metal and less than the wavelength of the incident light; and an external voltage source can modulate the color of the reflected light, and can achieve voltage modulation of the color of reflected light in the visible light band.

Abstract: The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and easy to synthesize at high yield and purity in just a few steps using commercially available starting materials. The tagging reagents of the present invention comprise: a) a reporter group, having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an aldehyde, ketone, or carboxylic acid reactive group. The multiplex SUGAR tags are able to react with an aldehyde, ketone, or carboxylic acid group of the molecule to be tagged, which offers the capability for labeling and quantitation of glycans, proteins/peptides, and fatty acids.

Abstract: A complete capillary electrophoresis (CE) system that is capable of providing a continuous flow of effluent at the exit of the flow-through outlet vial is provided. A self-contained capillary electrophoresis system with a flow-through outlet vial for interfacing with mass spectrometry includes a capillary having an upstream inlet end and a downstream terminus end; an electrically conductive hollow needle having an inner wall defining an internal tapered chamber, the internal tapered chamber dimensioned and configured to slidably accept the terminus end of the capillary, the capillary longitudinally inserted into and mounted within the internal tapered chamber to a distance whereby the terminus end of the capillary abuts the inner wall of the needle at the taper; and wherein a micro-reservoir is formed between the terminus end of the capillary and the downstream exit orifice.

Abstract: A complete capillary electrophoresis (CE) system that is capable of providing a continuous flow of effluent at the exit of the flow-through outlet vial is provided. A self-contained capillary electrophoresis system with a flow-through outlet vial for interfacing with mass spectrometry includes a capillary having an upstream inlet end and a downstream terminus end; an electrically conductive hollow needle having an inner wall defining an internal tapered chamber, the internal tapered chamber dimensioned and configured to slidably accept the terminus end of the capillary, the capillary longitudinally inserted into and mounted within the internal tapered chamber to a distance whereby the terminus end of the capillary abuts the inner wall of the needle at the taper; and wherein a micro-reservoir is formed between the terminus end of the capillary and the downstream exit orifice.