Abstract: A water detection device (100) may have a water sensor on both a top and bottom of the device. A water sensor circuit (1004,1006,1100, 1101) may be configured to detect water by delivering a signal may be delivered to an electrical contact (1104, 1132), and the presence of water may be determined based upon detection of the signal at the other contact (1106, 1134). The water sensor circuit device (1101) may be configured with a comparator (1116) that uses hysteresis to provide sensitivity to the presence or absence of water. In a battery-powered water sensor, the water detection signal may be delivered as an alternating signal using, e.g., a signal modulator circuit (e.g., an oscillator circuit (1114) and gate (1120) optionally coupled to a wake-sleep controller (1112)) that is coupled to a battery (133), which may avoid oxidation or other forms of ionic corrosion. In some examples, a water detection signal may be recurrently delivered to the first contact (1132) to conserve battery power.

Abstract: An apparatus is described. The apparatus includes an add-in card having a power connector to receive power other than through the add-in card's host connector. The power connector fitted in a notch of a printed circuit board of the add-in card so that, when the printed circuit board is oriented to have an upper surface with semiconductor chips disposed thereon, an upper surface of the connector is above the upper surface of the printed circuit board and a lower surface of the connector is below a lower surface of the printed circuit board.

Abstract: A water detection device (100) may have a water sensor on both a top and bottom of the device. A water sensor circuit (1004,1006,1100, 1101) may be configured to detect water by delivering a signal may be delivered to an electrical contact (1104, 1132), and the presence of water maybe determined based upon detection of the signal at the other contact (1106, 1134). The water sensor circuit device (1101) may be configured with a comparator (1116) that uses hysteresis to provide sensitivity to the presence or absence of water. In a battery-powered water sensor, the water detection signal may be delivered as an alternating signal using, e.g., a signal modulator circuit (e.g., an oscillator circuit(1114) and gate (1120) optionally coupled to a wake-sleep controller (1112)) that is coupled to a battery (133), which may avoid oxidation or other forms of ionic corrosion. In some examples, a water detection signal may be recurrently delivered to the first contact (1132) to conserve battery power.

Abstract: Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.

Abstract: Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.

Abstract: The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.

Abstract: The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.