Abstract: A mechanical type lifting shifter provided below a wheelchair body, including a bottom supporting assembly having a pair of oppositely arranged supporting members and gear rack columns provided on the supporting members; a movable upper supporting assembly having movable supporting members slidably sleeving the gear rack columns; a gear roller assembly having a rotating shaft and a pair of lifting gears provided on the two end portions of the rotating shaft; two ends of the rotating shaft are respectively and fixedly connected to a pair of movable supporting members and support the movable supporting members, and the lifting gears are engaged with the gear rack columns; a pedal transmission assembly mounted on the rotating shaft and in transmission connection with the rotating shaft; and a pedal clutch assembly connected to the pedal transmission assembly to switch clockwise and anti-clockwise motion transmission between the pedal transmission assembly and the rotating shaft.

Abstract: A transfer machine includes a main body assembly and a lifting assembly. The main body assembly includes two lifting rods capable of moving up and down and two seat plates facing the lifting rods. Each seat plate can rotate around the corresponding lifting rod thereby enabling the two seat plates to close or separate from each other. The lifting assembly includes a base, a connecting rod and a control assembly fixedly connected to the lifting rods. The base includes two guiding rods extending up and down, and each lifting rod can move in the up-down direction along the guiding rod. The control assembly includes a pushing rod, connected to the connecting rod; and a drive arm, driving the lifting rods to move in the up-down direction, thereby driving the main body assembly to move up and down. The connecting rod includes two foot sections.

Abstract: A transfer machine includes: a main body assembly, including two lifting rods capable of moving up and down, two seat plates corresponding to the two lifting rods, wherein the seat plates are capable of rotating around the corresponding lifting rods, allowing the seat plates to close with or separate from each other; a lifting assembly, including a base, a connecting rod fixedly connected to the lifting rods and an electronic controlling assembly. The base includes a guiding bar extending vertically, the lifting rods can move along the guiding bar; the electronic controlling assembly includes a pushing rod, fixedly connected to the connecting rod to drive the two lifting rods to move to further drive the main body assembly to move. The connecting rod has a first connection portion and a second connection portion, a foot section is formed between the first connection portion and the second connection portion.

Abstract: A mechanical type lifting shifter provided below a wheelchair body, including a bottom supporting assembly having a pair of oppositely arranged supporting members and gear rack columns provided on the supporting members; a movable upper supporting assembly having movable supporting members slidably sleeving the gear rack columns; a gear roller assembly having a rotating shaft and a pair of lifting gears provided on the two end portions of the rotating shaft; two ends of the rotating shaft are respectively and fixedly connected to a pair of movable supporting members and support the movable supporting members, and the lifting gears are engaged with the gear rack columns; a pedal transmission assembly mounted on the rotating shaft and in transmission connection with the rotating shaft; and a pedal clutch assembly connected to the pedal transmission assembly to switch clockwise and anti-clockwise motion transmission between the pedal transmission assembly and the rotating shaft.

Abstract: A vaporizer device may include a shell, a cartridge receptacle, and a skeleton. The cartridge receptacle may be formed from a cartridge interface disposed at least partially inside a sheath. The cartridge interface may be configured to provide a plurality of electrical couplings with a vaporizer cartridge when the vaporizer cartridge is disposed inside the cartridge receptacle. The plurality of electrical couplings may include a first electrical coupling with a heating element of the vaporizer cartridge. The plurality of electrical couplings may further include a second electrical coupling with a cartridge identification chip of the vaporizer cartridge. The skeleton may be coupled with the cartridge interface. The skeleton may be configured to secure the cartridge interface inside the shell.

Abstract: The present disclosure relates generally to an improved gaming machine that facilitates automated or semi-automated user interactions therewith. Illustratively, a method is provided that includes generating a game history message for delivery to a mobile device, transmitting the game history message to the mobile device, receiving a wager strategy message from the mobile device, and extracting, from the wager strategy message, a wager strategy for the player to be applied at the gaming machine for a game of chance to be played after receiving the wager strategy message. The method may further include executing the game of chance by placing a wager for the player on the game of chance in accordance with the wager strategy extracted from the wager strategy message.

Abstract: The present disclosure relates generally to an improved gaming machine that facilitates automated or semi-automated user interactions therewith. Illustratively, a method is provided that includes generating a game history message for delivery to a mobile device, transmitting the game history message to the mobile device, receiving a wager strategy message from the mobile device, and extracting, from the wager strategy message, a wager strategy for the player to be applied at the gaming machine for a game of chance to be played after receiving the wager strategy message. The method may further include executing the game of chance by placing a wager for the player on the game of chance in accordance with the wager strategy extracted from the wager strategy message.

Abstract: A cartridge may include a cartridge housing, a reservoir and a wick housing disposed inside the cartridge housing, a heating element, and a wicking element. The cartridge housing may be configured to extend below an open top of a receptacle in the vaporizer device when the cartridge is coupled with the vaporizer device. The reservoir may be configured to contain a vaporizable material. The heating element may include a heating portion disposed at least partially inside the wick housing and a contact portion disposed at least partially outside the wick housing. The contact portion may include cartridge contacts that form an electric coupling with receptacle contacts in the receptacle. The wicking element may be disposed within the wick housing and proximate to the heating portion of the heating element. The wicking element may be configured to draw the vaporizable material to the wick housing for vaporization by the heating element.

Abstract: An electrical connector assembly comprises a receptacle electrical connector and a plug electrical connector. The receptacle electrical connector includes a first body having a first and a second tongues and a plurality of first terminals, the first terminals located on opposite surfaces of the first tongue and offset relative to each other. The plug electrical connector includes a second body and a third and fourth mating chambers located in the second body; a plurality of third terminals, wherein the third terminals located on upper and lower sides of the third mating chamber are offset relative to each other. The receptacle electrical connector and the plug electrical connector can mate with each other so the first terminals and the third terminals are mated with each other to transmit signals and the second tongue and the fourth mating chamber are connected to transmit power.

Abstract: An electrical connector assembly comprises a receptacle electrical connector and a plug electrical connector. The receptacle electrical connector includes a first body having a first and a second tongues and a plurality of first terminals, the first terminals located on opposite surfaces of the first tongue and offset relative to each other. The plug electrical connector includes a second body and a third and fourth mating chambers located in the second body; a plurality of third terminals, wherein the third terminals located on upper and lower sides of the third mating chamber are offset relative to each other. The receptacle electrical connector and the plug electrical connector can mate with each other so the first terminals and the third terminals are mated with each other to transmit signals and the second tongue and the fourth mating chamber are connected to transmit power.

Abstract: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.

Abstract: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.

Abstract: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.

Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.

Abstract: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.

Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.

Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.

Abstract: A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.

Abstract: An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.

Abstract: A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.