Abstract: The present invention discloses a multi-beamforming optimization method for space-based ADS-B based on a coverage matrix. The method includes: calculating signal-to-noise ratios of received signals based on an ADS-B signal model and an air-space channel model; deriving the correct reception probability of ADS-B signals by a satellite with different signal-to-noise ratios and with different numbers of aircraft on the basis of analyzing a correct decoding probability and a collision probability; and in the case that the constraint of satellite coverage metric is satisfied, aiming at minimizing the update interval of position messages at the update probability of 95%, establishing a digital multi-beamforming optimization model for space-based ADS-B.

Abstract: The present invention discloses a coevolution-based multi-beamforming optimizing method for space-based ADS-B, which belongs to the field of aviation technologies. According to this method, after initializing population and acquiring an initial optimal solution, optimization parameters are firstly grouped randomly so that all beams form several significant uncovered regions. Then, grouping is performed by an adaptive grouping strategy based on the relative orientation between the mean center of the largest uncovered region and the direction of each beam, so that the parameters quickly converge to a full-coverage state within the half angle of the satellite. Finally, grouping is performed by a grouping strategy based on the aircraft density covered by each beam to obtain optimally the minimal update time interval under a full-coverage constraint.

Abstract: Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

Abstract: Embodiments of the present disclosure are directed to a polymeric composition comprising the cross-linked reaction product of an ionomer and a silane crosslinking agent. The ionomer may include an E/X/Y polymer where E is an ethylene monomer, X is ?,?-ethylenically unsaturated carboxylic acid comonomer having 3 to 8 carbons, or its ester, and Y is alkyl acrylate or dicarboxylic acid comonomer. The ionomer comprises from 1 to 30 wt. % of X and from 0 to 40 wt. % of Y. At least a portion of the carboxyl groups of X and optionally Y are neutralized with a metal cation. The silane crosslinking agent has a formula Z((CH2)aSi(OR)b)c. Z is a mono-functional reactive group, R is an alkyl group having 1 to 4 carbon atoms or a hydrogen atom, a is from 1 to 4, b is 3, and c is from 1 to 2.

Abstract: The present disclosure relates to aflibercept, in particular, attributes of aflibercept. Also provided herein are methods of characterizing and modifying the attributes of aflibercept and compositions comprising aflibercept with particular attributes.

Abstract: A shutter assembly includes at least two first shutter frame strips, at least two second shutter frame strips, and at least two support beams. The first shutter frame strips are detachably provided at a first side of each of the support beams. The second shutter frame strips are detachably provided at a second side of each of the support beams. The first shutter frame strips and the second shutter frame strips are staggered in a length direction of the first support beam. In the present shutter assembly, the first shutter frame strips and the second shutter frame strips are staggered at two sides of each of the support beams. A gap region between two adjacent first shutter frame strips is exactly obstructed by the corresponding second shutter frame strip. A gap region between two adjacent second shutter frame strips is exactly obstructed by the corresponding first shutter frame strip.

Abstract: A method for controlling movement of a cursor on an electronic device, a mobile device, and. an electronic device are provided.

Abstract: A cost-effective, efficient, and innovative system of the invention integrates the state-of-the art of the facilities, Unmanned Aerial Vehicle, computer-based tools, quantitative standard values, optionally along with fuzzy logic, to assess GI performance based on factors such as plant density percentages, plant health condition, and invasive plant numbers. A UAV drone is used to take images above the plants and analyze the images to get the plant density percentage for various GI sites. The Normalized Difference Vegetation Index (NDVI) value is calculated and used to analyze images and investigate the plant health conditions. NDVI values between ?1 and 0 correspond to non-plant surfaces, such as equipment, water, or soil. The higher the NDVI value, the greater their density and health. For counting invasive plant numbers, a machine/deep learning method may be applied to enhance invasive plant features to detect and enumerate invasive plants among normal plants in the captured images.

Abstract: Provided is a multi-objective path planning method for an intelligent public transport system, includes: generating a shortest path network topology for connecting bus stops by analyzing a traffic network topology and bus drivable paths; dynamically and evenly allocate bus routes according to passenger waiting periods, road lengths, and the shortest path network topology, to thereby allocate different routes for different buses; and determining an optimal bus route configuration according to average passenger travel distances, passenger experience, and the bus routes. The method can minimize a passenger waiting period while ensuring a high passenger load rate, thereby improving the overall efficiency of the public transport system and the travel experience of passengers.

Abstract: A method by one or more computing devices to configure an edge cloud to meet an end-to-end performance target for a microservices-based application that is implemented over the edge cloud and a mobile network is disclosed. The method includes determining a cloud-side performance target for the application based on the E2E performance target, network-side QoS control information, and network-side performance information, determining microservice instances of a microservice chain in the edge cloud that can be used to meet the cloud-side performance target for the application based on cloud-side service information, cloud-side resource usage information, and cloud-side performance information, determining cloud-side QoS parameters and a resource configuration for the microservice instances, and configuring the edge cloud to implement the microservice instances including applying the cloud-side QoS parameters and the resource configuration to the microservice instances.

Abstract: The present invention provides a compound of formula or a pharmaceutical salt thereof, use, methods for its preparation are described.

Abstract: A mining mobile communication system includes a first subsystem configured for communication in a licensed frequency band.

Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.

Abstract: An EP4 antagonist represented by formula I, which specifically comprises a crystal form thereof, a pharmaceutically acceptable salt or crystal form thereof, a preparation method therefor, a composition containing same, and a medical use of a related compound.

Abstract: A massage head unit, a vibration assembly and a smart wearable device, including: a soft rubber base plate, a plurality of vibrating members, a plurality of soft rubber massage heads, and a plurality of soft rubber pleated bodies capable of stretching and deforming in a axial direction of each massage head; the base plate, the pleat bodies and the massage heads are integrally molded by injection molding, the base plate is provided with a plurality of through holes penetrating therethrough, and the through holes, the pleated bodies and the massage heads are in one-to-one correspondence, each massage head is provided with a mounting cavity mounted with at least one vibrating member, each pleated body is connected to a bottom of the massage head and an edge of the through hole, such that each of the massage heads is floating and supported on the edge of the through hole.

Abstract: Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.

Abstract: The present disclosure relates to an electric motor cooling arrangement including an end oil spray assembly arranged at both ends of a stator of an electric motor, being used to spray cooling oil towards a winding head of the stator to cool the winding head, and a water cooling assembly arranged to surround at least the core part of the stator, wherein cooling water circulates in the water cooling assembly to cool the core part of the stator.

Abstract: A compound midazolam-D3 and its preparation method as it's synthesized from 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Compound II), by ring closure reaction with ethyl isocyanoacetate, hydrolysis with base, ring-opening with acid, ring closure under high temperature, and reacted with trideuteromethyl reagent; the synthetic route has advantage of short synthetic route appropriate, accessible and affordable. The prepared midazolam-D3 has characteristic with high purity, high deuterium content and very good stability.

Abstract: A method, computer system, and a computer program product for file transfer verification is provided. The present invention may include detecting a request to transmit a file from a user device to a target recipient. The present invention may also include extracting a recipient information associated with the target recipient. The present invention may further include marking the file on the user device to indicate the recipient information. The present invention may also include receiving a confirmation from the user device to transmit the file to the target recipient. The present invention may further include transmitting the file from the user device to the target recipient.

Abstract: An unnatural amino acid may have a structure as shown in formula (1) or may be an enantiomer thereof: Such unnatural amino acid may be used, e.g., in recombinant proteins. A recombinant protein may contain such unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid can be simple and convenient to prepare, safe in nature, difficult to inactivate when inserted into a protein, and may have a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate.