Patents by Inventor Xue-jun Li

Xue-jun Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 9080151
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: July 14, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 8597945
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: December 3, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of In Vitro Differentiation of Neural Stem Cells, Motor Neurons and Dopamine Neurons From Primate Embryonic Stem Cells
    Publication number: 20120184032
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: February 27, 2012
    Publication date: July 19, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 8153424
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 10, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Publication number: 20110275152
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: May 6, 2011
    Publication date: November 10, 2011
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 7972850
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: July 5, 2011
    Assignee: Wisonsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 7588937
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: September 15, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS
    Publication number: 20080227137
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 18, 2008
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Publication number: 20080206865
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: November 8, 2006
    Publication date: August 28, 2008
    Inventors: Su-Chun Zhang, James A. Thomson, Ian David Duncan, Xue-jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Publication number: 20050095706
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: August 27, 2004
    Publication date: May 5, 2005
    Inventors: Su-Chun Zhang, James Thomson, Ian Duncan, Xue-jun Li