Patents by Inventor Xuekun Zhang
Xuekun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240269276Abstract: The present invention relates to a specific binding protein targeting PD-L1 and CD73, wherein the specific binding protein is capable of specifically binding to PD-L1 and/or a fragment thereof, and CD73 and/or a fragment thereof. The present invention further relates to use of the specific binding protein in the treatment, prevention and/or diagnosis of diseases such as immune diseases, acute and chronic inflammatory diseases, and tumor diseases.Type: ApplicationFiled: May 24, 2022Publication date: August 15, 2024Inventors: Qianqian Shan, Xuekun Zhang, Xin Gan, Haishan Luo, Lei Shi, Yongqiang Wang, Xingxing Jia, Rongchao Wang, Yiping Rong
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Publication number: 20240034792Abstract: Provided are an antigen binding protein capable of binding to PD-1 and a fusion protein thereof, and corresponding preparation method therefor and the use thereof. The fusion protein is capable of targeting PD-1 and CD73.Type: ApplicationFiled: July 15, 2021Publication date: February 1, 2024Inventors: Haishan LUO, Qianqian SHAN, Yongqiang WANG, Xuekun ZHANG, Lei SHI, Yun ZHANG, Chuchu ZHAO, Wei ZHOU, Xin GAN
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Publication number: 20230322953Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.Type: ApplicationFiled: June 29, 2021Publication date: October 12, 2023Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTDInventors: Yun HE, Lei SHI, Haishan LUO, Qiang LV, Jinqiu HE, Zenglin PEI, Yongqiang WANG, Chen ZHONG, Bing HUANG, Jianxun ZHAO, Xingxing JIA, Xuekun ZHANG, Chuchu ZHAO, Fei CHEN, Lei NIU
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Publication number: 20220340673Abstract: Provided are an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications thereof. The antibody targeting BCMA comprises two heavy chain variable regions, the heavy chain variable regions comprising HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41. The antibody effectively targets human BCMA and binds to cynomolgus BCMA; the bispecific antibody effectively targets both human BCMA and human CD3, and can bind to cynomolgus BCMA and cynomolgus CD3.Type: ApplicationFiled: September 29, 2020Publication date: October 27, 2022Inventors: Lei SHI, Xuekun ZHANG, Yun HE, Jianxun ZHAO, Wei ZHOU, Fei CHEN, Xiangyang TAN, Yiping RONG
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Patent number: 9059767Abstract: Embodiments of the present invention disclose a microwave transmission method, apparatus, and system using CCDP and XPIC, and relate to the field of mobile communication technologies. The microwave transmission method includes: sending two channels of service that are corresponding to the same frequency and have different polarization directions, where the two channels of service are paired into one logical group; and when receiving, through a feedback channel, a failure signal sent by another end, closing sending of a channel of service that is indicated by the failure signal. In the embodiments of the present invention, after the failure signal sent by the another end is received, the sending of a channel of the service that is indicated by the failure signal is closed, so that no interference is caused to another channel of service, thus ensuring that another channel of service is received correctly.Type: GrantFiled: August 21, 2012Date of Patent: June 16, 2015Assignee: Huawei Technologies Co., Ltd.Inventor: Xuekun Zhang
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Patent number: 8917794Abstract: A method for sending service information includes: judging whether a current ACM profile identifier (profile ID) is consistent with an ACM profile ID recorded in separately-stored coding and modulation information; when the current ACM profile ID is consistent with the ACM profile ID recorded in the separately-stored coding and modulation information, coding and modulating the service information according to the coding and modulation information; when the current ACM profile ID is inconsistent with the ACM profile ID recorded in the separately-stored coding and modulation information, coding and modulating the service information according to an ACM profile table; and sending the coded and modulated service information, where the coded and modulated service information carries the current ACM profile ID.Type: GrantFiled: September 27, 2012Date of Patent: December 23, 2014Assignee: Huawei Technologies Co., Ltd.Inventors: Xuekun Zhang, Rui Chen, Cheng Chen
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Patent number: 8885785Abstract: Embodiments of the present invention disclose a CDR circuit and a terminal, where the CDR circuit is configured to perform clock synchronization in a terminal with EEE function, and the CDR circuit includes: a phase detector, a first phase signal selector, a loop filter, a numerical controlled oscillator, a second phase signal selector, a phase signal generator, and a state machine. In the embodiments of the present invention, after the terminal enters a REFRESH state from a QUIET state, the CDR circuit can implement clock synchronization with a peer end without waiting for the loop filter and the numerical controlled oscillator to be converged, but the phase signal generator generates a phase signal satisfying a preset clock synchronization condition, and the second phase signal selector selects the phase signal satisfying the preset clock synchronization condition as the phase selection signal of the CDR.Type: GrantFiled: August 29, 2013Date of Patent: November 11, 2014Assignee: Huawei Technologies Co., Ltd.Inventors: Xuekun Zhang, Jindi Zhang, Bo Yu, Faji Yin
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Publication number: 20140064422Abstract: Embodiments of the present invention disclose a CDR circuit and a terminal, where the CDR circuit is configured to perform clock synchronization in a terminal with EEE function, and the CDR circuit includes: a phase detector, a first phase signal selector, a loop filter, a numerical controlled oscillator, a second phase signal selector, a phase signal generator, and a state machine. In the embodiments of the present invention, after the terminal enters a REFRESH state from a QUIET state, the CDR circuit can implement clock synchronization with a peer end without waiting for the loop filter and the numerical controlled oscillator to be converged, but the phase signal generator generates a phase signal satisfying a preset clock synchronization condition, and the second phase signal selector selects the phase signal satisfying the preset clock synchronization condition as the phase selection signal of the CDR.Type: ApplicationFiled: August 29, 2013Publication date: March 6, 2014Applicant: Huawei Technologies Co., Ltd.Inventors: Xuekun ZHANG, Jindi ZHANG, Bo YU, Faji YIN
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Patent number: 8483047Abstract: A method, a terminal, and a system structure for transmitting and receiving services, which relate to the field of communication technology, so as to realize coordinated operation between Adaptive Code and Modulation and Hitless Switch Mode functions in a microwave communication system, thus improving system transmission efficiency and transmission reliability. The method for transmitting services includes the following steps. A transmitting end of an active link receives an ACM switching indication fed back by a receiving end of the active link, and a transmitting end of a standby link receives an ACM switching indication fed back by a receiving end of the standby link; the transmitting end of the active link performs ACM switching on the services transmitted through the active link and transmits the services; and the transmitting end of the standby link performs ACM switching on the services transmitted through the standby link and transmits the services.Type: GrantFiled: January 24, 2011Date of Patent: July 9, 2013Assignee: Huawei Technologies Co., Ltd.Inventor: Xuekun Zhang
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Publication number: 20120315865Abstract: Embodiments of the present invention disclose a microwave transmission method, apparatus, and system using CCDP and XPIC, and relate to the field of mobile communication technologies. The microwave transmission method includes: sending two channels of service that are corresponding to the same frequency and have different polarization directions, where the two channels of service are paired into one logical group; and when receiving, through a feedback channel, a failure signal sent by another end, closing sending of a channel of service that is indicated by the failure signal. In the embodiments of the present invention, after the failure signal sent by the another end is received, the sending of a channel of the service that is indicated by the failure signal is closed, so that no interference is caused to another channel of service, thus ensuring that another channel of service is received correctly.Type: ApplicationFiled: August 21, 2012Publication date: December 13, 2012Applicant: Huawei Technologies Co., Ltd.Inventor: Xuekun Zhang
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Patent number: 8229375Abstract: A transmitting device, a transmit power control method and a control device thereof in a microwave system are provided. The transmitting device includes a transmit power control module, adapted to acquire a switching event of a modulation mode of the microwave system, and adjust a transmit power of a radio frequency transmitting module according to the switching event and a preset power control mode; and the radio frequency transmitting module, adapted to send a microwave signal to a communication peer end by adopting the transmit power adjusted by the transmit power control module. Through setting the power control module, the gain of an AM microwave system is enhanced, and the service impairment caused by the AM microwave system when actuating an ATPC function is avoided.Type: GrantFiled: July 16, 2009Date of Patent: July 24, 2012Assignee: Huawei Technologies Co., Ltd.Inventors: Xiaobin Song, Xianfeng Li, Bangmei Deng, Xuekun Zhang, Yaoming Chen, Hui Song, Jian Pu
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Publication number: 20110182175Abstract: A method, a terminal, and a system structure for transmitting and receiving services, which relate to the field of communication technology, so as to realize coordinated operation between Adaptive Code and Modulation and Hitless Switch Mode functions in a microwave communication system, thus improving system transmission efficiency and transmission reliability. The method for transmitting services includes the following steps. A transmitting end of an active link receives an ACM switching indication fed back by a receiving end of the active link, and a transmitting end of a standby link receives an ACM switching indication fed back by a receiving end of the standby link; the transmitting end of the active link performs ACM switching on the services transmitted through the active link and transmits the services; and the transmitting end of the standby link performs ACM switching on the services transmitted through the standby link and transmits the services.Type: ApplicationFiled: January 24, 2011Publication date: July 28, 2011Applicant: HUAWEI TECHNOLOGIES CO., LTD.Inventor: Xuekun ZHANG
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Publication number: 20110170419Abstract: A method for instructing an Adaptive Code and Modulation (ACM) switching is provided, which is applied in a microwave communication system configured with an ACM function and a Hitless Switch Mode (HSM) function. The method includes: obtaining signal quality of an active link and signal quality of a standby link; generating an ACM switching instruction according to the better one between the signal quality of the active link and the signal quality of the standby link; and transmitting the ACM switching instruction to a transmitting device of the active link. A device and a system are also provided. Through the method, device and system, the available bandwidth of a link is fully utilized when the signal quality of the standby link is better than the signal quality of the active link.Type: ApplicationFiled: January 6, 2011Publication date: July 14, 2011Inventors: Xuekun Zhang, Bangmei Deng, Rui Chen
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Publication number: 20100151804Abstract: A transmitting device, a transmit power control method and a control device thereof in a microwave system are provided. The transmitting device includes a transmit power control module, adapted to acquire a switching event of a modulation mode of the microwave system, and adjust a transmit power of a radio frequency transmitting module according to the switching event and a preset power control mode; and the radio frequency transmitting module, adapted to send a microwave signal to a communication peer end by adopting the transmit power adjusted by the transmit power control module. Through setting the power control module, the gain of an AM microwave system is enhanced, and the service impairment caused by the AM microwave system when actuating an ATPC function is avoided.Type: ApplicationFiled: July 16, 2009Publication date: June 17, 2010Applicant: Huawei Technologies Co., Ltd.Inventors: Xiaobin Song, Xianfeng Li, Bangmei Deng, Xuekun Zhang, Yaoming Chen, Hui Song, Jian Pu