Abstract: Provided are a compound for the prevention and treatment of diseases associated with PD-L1, a preparation method therefor and use thereof. Specifically, provided are the compound of formula I, the stereoisomer and the racemate thereof, or pharmaceutically acceptable salts thereof, and also provided is an application thereof in the preparation of a drug for the prevention and treatment of diseases associated with PD-L1.

Abstract: The present invention provides preparation of a semicarbazide-sensitive amine oxidase inhibitor and use thereof. In particular, disclosed in the present invention are a compound as represented by formula I, or a stereoisomer or a racemate or a pharmaceutically acceptable salt of the compound. Also disclosed in the present invention is that the compound can inhibit semicarbazide-sensitive amine oxidase.

Abstract: Provided are a preparation of semicarbazide-sensitive amine oxidase inhibitor and the use thereof. In particular, disclosed are a compound as shown in formula I, or a stereoisomer or racemate or pharmaceutically acceptable salt thereof. Also disclosed is that the above-mentioned compound can inhibit semicarbazide-sensitive amine oxidase.

Abstract: The present invention discloses the preparation and application of heterocyclic compound having immunoregulatory function. Specifically, the present invention discloses a compound having a structure according to Formula I, wherein the definition of each group is as described in the specification. The invention also provides the use of the compounds in regulating immunity and inhibiting PD-1/PD-L1.

Abstract: Provided are an aromatic compound having immunoregulatory effect, a preparation method thereof, and a use of the same in regulating immune responses or inhibiting PD-1/PD-L1.

Abstract: Provided are a compound for the prevention and treatment of diseases associated with PD-L1, a preparation method therefor and use thereof. Specifically, provided are the compound of formula I, the stereoisomer and the racemate thereof, or pharmaceutically acceptable salts thereof, and also provided is an application thereof in the preparation of a drug for the prevention and treatment of diseases associated with PD-Ll.

Abstract: Disclosed herein is a method of analyzing examinee item response data comprising constructing a diagnosis model for reporting skill profiles of examinees, wherein the diagnosis model comprises at least a variable representing unobserved subpopulations, creating an item design matrix, distributing examinees across the unobserved subpopulations, iteratively estimating values for a plurality of variables within the diagnosis model, and reporting the estimated values to a user.

Abstract: The present invention relates to an anesthetic absorbing circle, comprising: a first common tube, providing an anesthetic gas mixture; an inspiration branch, connected to the first common tube and delivering the anesthetic gas mixture to a patient end; an expiration branch, connected to the first common tube and sending back the expired gas from the patient end to the first common tube; a second common tube, connected with the inspiration branch and the expiration branch at its first end and connected with the patient end at its second end; and a flow sensor, wherein the flow sensor is disposed in the first common tube. Thus, according to the present invention, the flow sensor can conduct bidirectional monitoring, the flow sensor is remote from patients, and water accumulation at the probe will not appear; in addition, the probe can be easily detached and disinfected at a high temperature, and can be used between adults and children.

Abstract: Disclosed herein is a method of analyzing large scale survey results comprising obtaining a sparse data set representing a subset of an original data set comprising a plurality of individuals' responses to a plurality of questions, wherein the sparse data set comprises less than ninety percent of the responses in the original data set; analyzing the sparse data set using a general diagnostic model; and obtaining estimated person parameters using the general diagnostic model.

Abstract: The present invention relates to an anesthetic absorbing circle, comprising: a first common tube, providing an anesthetic gas mixture; an inspiration branch, connected to the first common tube and delivering the anesthetic gas mixture to a patient end; an expiration branch, connected to the first common tube and sending back the expired gas from the patient end to the first common tube; a second common tube, connected with the inspiration branch and the expiration branch at its first end and connected with the patient end at its second end; and a flow sensor, wherein the flow sensor is disposed in the first common tube. Thus, according to the present invention, the flow sensor can conduct bidirectional monitoring, the flow sensor is remote from patients, and water accumulation at the probe will not appear; in addition, the probe can be easily detached and disinfected at a high temperature, and can be used between adults and children.

Abstract: Disclosed herein is a method of analyzing examinee item response data comprising constructing a diagnosis model for reporting skill profiles of examinees, wherein the diagnosis model comprises at least a variable representing unobserved subpopulations, creating an item design matrix, distributing examinees across the unobserved subpopulations, iteratively estimating values for a plurality of variables within the diagnosis model, and reporting the estimated values to a user.

Abstract: Disclosed herein is a method of analyzing large scale survey results comprising obtaining a sparse data set representing a subset of an original data set comprising a plurality of individuals' responses to a plurality of questions, wherein the sparse data set comprises less than ninety percent of the responses in the original data set; analyzing the sparse data set using a general diagnostic model; and obtaining estimated person parameters using the general diagnostic model.