Abstract: Provided herein are compositions and methods for reducing neuroinflammation and treating neurodegenerative diseases using proteinase inhibitors. The invention also provides methods for reducing post-injury scar formation in the central nervous system.

Abstract: The invention features methods and compositions that are useful for the treatment of diseases, disorders, conditions, or injuries characterized by insufficient myelination. The methods involve administering GPR17 antagonists and microglia inhibitors or ablation agents.

Abstract: Some embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising a myelination enhancing inhibitor to the animal. Other embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Still other embodiments of the invention include methods for treating an animal for MS or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Additional embodiments of the invention are also discussed herein.

Abstract: Some embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising a myelination enhancing inhibitor to the animal. Other embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Still other embodiments of the invention include methods for treating an animal for MS or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Additional embodiments of the invention are also discussed herein.

Abstract: The present invention relates to a supported polymetal olefin polymerization catalyst, comprising a porous support, a magnesium-containing support component, a transition metal titanium component supported on the porous support, and further comprising at least one non-magnesium metal component supported on the porous support. Further provided is a preparation method and a use of the supported polymetal olefin polymerization catalyst. An efficient composite support supported polymetal Ziegler-Natta catalyst is provided in the present invention, wherein a porous support, a soluble magnesium compound, and a soluble non-magnesium metal compound are used as raw materials. The supporting of titanium is achieved while a composite support containing magnesium and non-magnesium metal components is formed in situ in the surface of the porous support. The present invention has the advantage of a simple preparation method, a low cost, a controllability of morphology, properties of the catalyst, etc.

Abstract: The present invention relates to a supported polymetal olefin polymerization catalyst, comprising a porous support, a magnesium-containing support component, a transition metal titanium component supported on the porous support, and further comprising at least one non-magnesium metal component supported on the porous support. Further provided is a preparation method and a use of the supported polymetal olefin polymerization catalyst. An efficient composite support supported polymetal Ziegler-Natta catalyst is provided in the present invention, wherein a porous support, a soluble magnesium compound, and a soluble non-magnesium metal compound are used as raw materials. The supporting of titanium is achieved while a composite support containing magnesium and non-magnesium metal components is formed in situ in the surface of the porous support. The present invention has the advantage of a simple preparation method, a low cost, a controllability of morphology, properties of the catalyst, etc.

Abstract: The present invention relates to a supported hybrid vanadium-chromium-based catalyst, characterized in the catalyst is supported on a porous inorganic carrier and a V active site and a inorganic Cr active site are present on the porous inorganic carrier at the same time. The present invention further relates to a process for producing a supported hybrid vanadium-chromium-based catalyst. The invention also provides the preparation method of the catalyst, titanium or fluorine compounds, vanadium salt and chromium salt according to the proportion, different methods of sequence and load on the inorganic carrier, after high temperature roasting, still can further add organic metal catalyst promoter prereduction activation treatment on it. The catalyst of the present invention can be used for producing ethylene homopolymers and ethylene/?-olefin copolymers.

Abstract: The present invention relates to a carriered hybrid vanadium-chromium-based catalyst, characterized in the catalyst is carriered on a porous inorganic carrier and a V active site and an organic Cr active site are present on the porous inorganic carrier at the same time. The present invention further relates to a process for producing a carriered hybrid vanadium-chromium-based catalyst. The catalyst of the present invention can be used for producing ethylene homopolymers and ethylene/?-olefin copolymers. The hybrid vanadium-chromium-based catalyst can have high activity and produce polyethylene polymers having the properties of broad molecular weight distribution (Part of the products are bimodal distribution) and excellent ?-olefin copolymerization characteristic.

Abstract: The present invention relates to a carriered hybrid vanadium-chromium-based catalyst, characterized in the catalyst is carriered on a porous inorganic carrier and a V active site and an organic Cr active site are present on the porous inorganic carrier at the same time. The present invention further relates to a process for producing a carriered hybrid vanadium-chromium-based catalyst. The catalyst of the present invention can be used for producing ethylene homopolymers and ethylene/?-olefin copolymers. The hybrid vanadium-chromium-based catalyst can have high activity and produce polyethylene polymers having the properties of broad molecular weight distribution (Part of the products are bimodal distribution) and excellent ?-olefin copolymerization characteristic.

Abstract: The present invention relates to a supported hybrid vanadium-chromium-based catalyst, characterized in the catalyst is supported on a porous inorganic carrier and a V active site and a inorganic Cr active site are present on the porous inorganic carrier at the same time. The present invention further relates to a process for producing a supported hybrid vanadium-chromium-based catalyst. The invention also provides the preparation method of the catalyst, titanium or fluorine to compounds, vanadium salt and chromium salt according to the proportion, different methods of sequence and load on the inorganic carrier, after high temperature roasting, still can further add organic metal catalyst promoter prereduction activation treatment on it. The catalyst of the present invention can be used for producing ethylene homopolymers and ethylene/?-olefin copolymers.