Patents by Inventor Xuemei Cao

Xuemei Cao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY CONJUGATE AND APPLICATION OF PHARMACEUTICAL COMPOSITION THEREOF
    Publication number: 20220226334
    Abstract: An application of an antibody conjugate in the preparation of a drug for treating CD30 positive tumors, which is characterized in that: the antibody conjugate is F0002-ADC; the general formula of the structural thereof is Ab-Lm-Yn; and the CD30-positive tumors are CD30-positive tumors that express a multidrug resistance gene 1. In addition, a pharmaceutical combination and a pharmaceutical composition containing the antibody conjugate, which may be applied to the preparation of a drug used for treating CD30-positive tumors.
    Type: Application
    Filed: May 21, 2019
    Publication date: July 21, 2022
    Inventors: Yijun SHEN, Tong YANG, Yanjun LIU, Qingsong GUO, Xuemei CAO, Hua LI, Bei GAO, Guanghao WU, Likai MENG, Yanbo GAO, Yang ZHU
  • MARKED BOVINE VIRAL DIARRHEA VIRUS VACCINES
    Publication number: 20120021001
    Abstract: The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
    Type: Application
    Filed: June 22, 2011
    Publication date: January 26, 2012
    Applicant: PFIZER INC.
    Inventors: Chichi Huang, Michael G. Sheppard, Xuemei Cao, Gabriele M. Zybarth
  • Safe mutant viral vaccines
    Patent number: 7754222
    Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: July 13, 2010
    Assignee: Pharmacia & Upjohn Company, LLC
    Inventors: Siao-Kun Wan Welch, Jay Gregory Calvert, Michael K O'Hara, Xuemei Cao
  • Marked Bovine Viral Diarrhea Virus Vaccines
    Publication number: 20080305130
    Abstract: The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
    Type: Application
    Filed: November 24, 2006
    Publication date: December 11, 2008
    Inventors: Chichi Huang, Michael G. Sheppard, Xuemei Cao, Gabriele M. Zybarth
  • Safe Mutant Viral Vaccines
    Publication number: 20080286302
    Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
    Type: Application
    Filed: April 4, 2008
    Publication date: November 20, 2008
    Applicants: PFIZER INC., PFIZER PRODUCTS INC.
    Inventors: Siao-Kun Wan Welsh, Jay Gregory Calvert, Michael K. O'Hara, Xuemei Cao
  • Safe mutant viral vaccines
    Patent number: 7361357
    Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic adds contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: April 22, 2008
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Siao-Kun Wan Welch, Jay Gregory Calvert, Michael K. O'Hara, Xuemei Cao
  • Generation of type I/type II hybrid form of bovine viral diarrhea virus for use as vaccine
    Patent number: 6974575
    Abstract: The present invention provides genetically engineered type I/type II hybrid BVDV viruses. The hybrid viruses, as well as the hybrid viral genome, can be used in immunogenic compositions and vaccines for protecting cattle from BVDV infection.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: December 13, 2005
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Xuemei Cao, Gabriele M. Zybarth
  • Attenuated forms of bovine viral diarrhea virus
    Patent number: 6916477
    Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: July 12, 2005
    Assignee: Pfizer Inc.
    Inventors: Xuemei Cao, Michael G. Sheppard
  • Safe mutant viral vaccines
    Publication number: 20050053621
    Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic adds contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
    Type: Application
    Filed: July 16, 2004
    Publication date: March 10, 2005
    Inventors: Siao-Kun Welch, Jay Calvert, Michael O'Hara, Xuemei Cao
  • Attenuated forms of bovine viral diarrhea virus
    Publication number: 20040146854
    Abstract: The present invention relates to attenuated forms of bovine viral diarrhea (BVD) viruses. In particular, the present invention relates to attenuated BVD viruses made by mutating the Npro protease gene and inserting a bovine ubiquitin coding sequence. The attenuated viruses of the present invention can be used to raise antibodies against BVDV. Immunogenic compositions and vaccine compositions, as well as therapeutic and diagnosis methods, are also provided by the present invention.
    Type: Application
    Filed: November 21, 2001
    Publication date: July 29, 2004
    Applicant: Pfizer Inc.
    Inventors: Xuemei Cao, Gabriele M. Zybarth
  • Attenuated forms of bovine viral diarrhea virus
    Publication number: 20030165520
    Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
    Type: Application
    Filed: April 29, 2002
    Publication date: September 4, 2003
    Inventors: Xuemei Cao, Michael G. Sheppard
  • Generation of type I/type II hybrid form of bovine viral diarrhea virus for use as vaccine
    Publication number: 20030104612
    Abstract: The present invention provides genetically engineered type I/type II hybrid BVDV viruses. The hybrid viruses, as well as the hybrid viral genome, can be used in immunogenic compositions and vaccines for protecting cattle from BVDV infection.
    Type: Application
    Filed: August 27, 2002
    Publication date: June 5, 2003
    Applicant: Pfizer Inc.
    Inventors: Xuemei Cao, Gabriele M. Zybarth
  • Attenuated forms of bovine viral diarrhea virus
    Patent number: 6410032
    Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by the method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: June 25, 2002
    Assignee: Pfizer Inc
    Inventors: Xuemei Cao, Michael G. Sheppard
  • Attenuated forms of bovine viral diarrhea virus
    Patent number: 6410299
    Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: June 25, 2002
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Xuemei Cao, Michael G. Sheppard
  • Attenuated forms of bovine viral diarrhea virus
    Patent number: 6168942
    Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: January 2, 2001
    Assignee: Pfizer Inc.
    Inventors: Xuemei Cao, Michael G. Sheppard