Patents by Inventor Xuemei Du

Xuemei Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biaryl Sulfonamides and Methods for Using Same
    Publication number: 20100137298
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Application
    Filed: June 13, 2008
    Publication date: June 3, 2010
    Applicant: Wyeth
    Inventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
  • Biaryl sulfonamides and methods for using same
    Patent number: 7420001
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: September 2, 2008
    Assignee: Wyeth
    Inventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
  • Biaryl sulfonamides and methods for using same
    Publication number: 20050143422
    Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
    Type: Application
    Filed: December 1, 2004
    Publication date: June 30, 2005
    Applicant: Wyeth
    Inventors: Jeremy Levin, Thomas Rush, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Wu, Rajeev Hotchandani, Jason Xiang, Xuemei Du, Derek Cole, Steve Tam
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
    Patent number: 6548524
    Abstract: This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-&agr; converting enzyme (TACE. tumor necrosis factor-&agr; converting enzyme) which arc useful for the treatment of diseases in which these enzymes are implicated.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: April 15, 2003
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Patent number: 6534491
    Abstract: This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stroinelysins and collagenases) and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr;converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: March 18, 2003
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Patent number: 6498167
    Abstract: This invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr; converting enzyme) of formula (B) as shown herein or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: December 24, 2002
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Publication number: 20020132826
    Abstract: This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr; converting enzyme) of formula:
    Type: Application
    Filed: December 11, 2000
    Publication date: September 19, 2002
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
    Publication number: 20010046989
    Abstract: This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr; converting enzyme) of formula:
    Type: Application
    Filed: December 11, 2000
    Publication date: November 29, 2001
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Publication number: 20010025047
    Abstract: This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr; converting enzyme) of formula:
    Type: Application
    Filed: December 11, 2000
    Publication date: September 27, 2001
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
    Patent number: 6228869
    Abstract: This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr; converting enzyme) of formula: B wherein B is P and Q are provided that when P is Q is and vice versa; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: May 8, 2001
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
    Patent number: 6071903
    Abstract: Compounds are provided having the following formula: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification, which have matrix metalloproteinase inhibiting activity.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: June 6, 2000
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5854236
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: December 29, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5786353
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: July 28, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5739128
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: April 14, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Xuemei Du
  • Tricyclic Benzazepine vasopressin antagonists
    Patent number: 5736538
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: April 7, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5719278
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: February 17, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos, Xuemei Du, Marvin F. Reich
  • Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists
    Patent number: 5686445
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: April 25, 1996
    Date of Patent: November 11, 1997
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5532235
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: July 2, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos, Xuemei Du, Marvin E. Reich, Aranapakam M. Venkatesan
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5512563
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: April 30, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Fuk-Wah Sum, Xuemei Du