Patents by Inventor Xuemei He

Xuemei He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240261775
    Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 8, 2024
    Inventors: CHRISTOPHER BELISLE, XUEMEI HE, HONG CHEN, YUEPING XU, JIALI LIAO
  • Patent number: 11896969
    Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 13, 2024
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Christopher Belisle, Xuemei He, Hong Chen, Yueping Xu, Jiali Liao
  • Publication number: 20230264171
    Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
    Type: Application
    Filed: April 27, 2023
    Publication date: August 24, 2023
    Inventors: CHRISTOPHER BELISLE, HONG CHEN, YUEPING XU, JIALI LIAO, XUEMEI HE
  • Patent number: 11696588
    Abstract: A movable controlled atmosphere store for fruits and vegetables, including: a store body in rectangular container structure and successively provided with an equipment room and a storage room along length direction; the equipment room is provided with an equipment door respectively on left and right sides; the storage room is in thermal insulation and sealing structure and provided with a sealing door at an end far away from the equipment room, and is provided with a sampling door on a side which is provided with a sealing film connected around a frame thereof, and a sampling assembly connected with the sealing film in cylindrical structure; a controlled atmosphere control system, including a control panel, as well as a refrigerator, a humidifier, a sterilizer, a nitrogen generator, a carbon dioxide adsorber, an ethylene adsorber, a temperature and humidity sensor and a gas concentration sensing device connected with the control panel.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: July 11, 2023
    Assignee: GUANGXI ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Jian Sun, Li Li, Jiemin Li, Changbao Li, Xuemei He, Ming Xin, Zhugui Zhou, Jinfeng Sheng, Fengjin Zheng, Zhichun Li, Zhanshi Xiao, Guoming Liu, Yayuan Tang, Ying Yang, Dongning Ling
  • Patent number: 11666888
    Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: June 6, 2023
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Christopher Belisle, Hong Chen, Yueping Xu, Jiali Liao, Xuemei He
  • Patent number: 11590486
    Abstract: A method for manufacturing a mixed-mode chromatography medium is provided. The method can include, for example, oxidizing diol groups on diol-functionalized solid particles having pores of a median diameter of 0.5 micron or greater with substantially no pores of 0.1 micron or less in diameter and having a diol density of from about 200 to about 300 ?mol/mL to aldehyde groups, thereby converting said diol-functionalized solid particles to aldehyde-functionalized solid particles; and coupling amine-functionalized ligands to said aldehyde-functionalized solid particles, said amine-functionalized ligands comprising an amine-substituted hydrophobic group joined to an acid moiety selected from the group consisting of a carboxyl group and a sulfo group.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: February 28, 2023
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Jiali Liao, Lee Olech, Hong Chen, Xuemei He, Russell Frost
  • Patent number: 11565830
    Abstract: A method for calculating an optimal wheel position control angle of passenger boarding bridge automatic docking system includes collecting ranging information of a sensor to rotate the bridgehead direction via a distance measuring sensor on both sides of the bridgehead of the passenger boarding bridge, making the bridgehead parallel to the aircraft fuselage; collecting information of an aircraft door by a camera at the bridge head of the passenger boarding bridge to obtain a center position D of the aircraft door; in an ideal docking situation, the aircraft door should appear at the bridge head position as D?; the position where D? is projected vertically onto the aircraft fuselage is D?, that is, the line segment DD? is the horizontal distance deviation between the current passenger boarding bridge and the aircraft door, the line segment D?D? is the distance between the current boarding bridge and the aircraft fuselage.
    Type: Grant
    Filed: February 7, 2021
    Date of Patent: January 31, 2023
    Assignee: UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA
    Inventors: Run Ye, Bin Yan, Cheng Zhang, Xuemei He, Xiaojia Zhou
  • Publication number: 20210368814
    Abstract: A movable controlled atmosphere store for fruits and vegetables, including: a store body in rectangular container structure and successively provided with an equipment room and a storage room along length direction; the equipment room is provided with an equipment door respectively on left and right sides; the storage room is in thermal insulation and sealing structure and provided with a sealing door at an end far away from the equipment room, and is provided with a sampling door on a side which is provided with a sealing film connected around a frame thereof, and a sampling assembly connected with the sealing film in cylindrical structure; a controlled atmosphere control system, including a control panel, as well as a refrigerator, a humidifier, a sterilizer, a nitrogen generator, a carbon dioxide adsorber, an ethylene adsorber, a temperature and humidity sensor and a gas concentration sensing device connected with the control panel.
    Type: Application
    Filed: August 1, 2019
    Publication date: December 2, 2021
    Applicant: GUANGXI ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Jian SUN, Li LI, Jiemin LI, Changbao LI, Xuemei HE, Ming XIN, Zhugui ZHOU, Jinfeng SHENG, Fengjin ZHENG, Zhichun LI, Zhanshi XIAO, Guoming LIU, Yayuan TANG, Ying YANG, Dongning LING
  • Publication number: 20210339886
    Abstract: A method for calculating an optimal wheel position control angle of passenger boarding bridge automatic docking system includes collecting ranging information of a sensor to rotate the bridgehead direction via a distance measuring sensor on both sides of the bridgehead of the passenger boarding bridge, making the bridgehead parallel to the aircraft fuselage; collecting information of an aircraft door by a camera at the bridge head of the passenger boarding bridge to obtain a center position D of the aircraft door; in an ideal docking situation, the aircraft door should appear at the bridge head position as D?; the position where D? is projected vertically onto the aircraft fuselage is D?, that is, the line segment DD? is the horizontal distance deviation between the current passenger boarding bridge and the aircraft door, the line segment D?D? is the distance between the current boarding bridge and the aircraft fuselage.
    Type: Application
    Filed: February 7, 2021
    Publication date: November 4, 2021
    Inventors: Run YE, Bin YAN, Cheng ZHANG, Xuemei HE, Xiaojia ZHOU
  • Publication number: 20210086165
    Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
    Type: Application
    Filed: February 5, 2019
    Publication date: March 25, 2021
    Inventors: CHRISTOPHER BELISLE, HONG CHEN, YUEPING XU, JIALI LIAO, XUEMEI HE
  • Publication number: 20210069692
    Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.
    Type: Application
    Filed: September 4, 2020
    Publication date: March 11, 2021
    Inventors: CHRISTOPHER BELISLE, XUEMEI HE, HONG CHEN, YUEPING XU, JIALI LIAO
  • Publication number: 20200406232
    Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands, that are useful for purifying target biomolecules using anionic exchange (i.e., where the ligand is positively charged) and hydrophobic mixed mode chromatography. The chromatography resins allow for efficient purification of target biomolecules (e.g., recombinant proteins, antibodies, antibody-drug conjugates, or antibody derivatives including, but not limited to, antibody fragments and antibody fusions) from a sample, and have been found to be useful in purifying monomeric target biomolecules from aggregate target biomolecules. In an embodiment, the chromatography resins are useful for separating antibodies from one or more components (e.g., contaminants) in the sample.
    Type: Application
    Filed: March 8, 2019
    Publication date: December 31, 2020
    Inventors: CHRISTOPHER BELISLE, HONG CHEN, YUEPING XU, JIALI LIAO, XUEMEI HE
  • Publication number: 20200391196
    Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.
    Type: Application
    Filed: August 31, 2020
    Publication date: December 17, 2020
    Inventors: Jiali LIAO, Lee OLECH, Hong CHEN, Xuemei HE, Russell FROST
  • Patent number: 10792654
    Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand comprising benzamidoacetic acid to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between a phenyl ring and the support matrix.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: October 6, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Jiali Liao, Lee Olech, Hong Chen, Xuemei He, Russell Frost
  • Publication number: 20160184813
    Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Inventors: Jiali LIAO, Lee OLECH, Hong CHEN, Xuemei HE, Russell FROST
  • Patent number: 9309282
    Abstract: Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: April 12, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Jiali Liao, Lee Olech, Hong Chen, Xuemei He, Russell Frost