Patents by Inventor Xuemei Li

Xuemei Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11155483
    Abstract: A method for efficiently producing PHA comprising: inoculating PHA fermentation strains into a fermentation medium for fermentation under the condition of being capable of producing PHA through fermentation; subjecting the fermentation broth to a solid-liquid separation to obtain fermentation supernatant and thallus precipitate; breaking the cell walls of the thallus precipitate, and subjecting the wall-broken products to a plate and frame filtration to prepare PHA; pre-coating a filter cloth for the plate and frame filtration with a PHA layer; at least part of the water of the fermentation medium is PHA process wastewater. The method utilizes the PHA process wastewater as at least part of the water of the fermentation medium, and filters and separates the broken thallus with the plate and frame filtration equipment pre-coated with PHA layer to prepare PHA, thereby recycling the high-salt wastewater, reducing costs, and potentially separating PHA on a large scale for industrial production.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: October 26, 2021
    Assignees: Nutrition & Health Research Institute, COFCO Corporation, COFCO (jilin) Bio-Chemical Technology CO., Ltd, COFCO Biotechnology Co., Ltd., Tsinghua University
    Inventors: Yi Tong, Yi Li, Fang Tian, Weiqiang Zhou, Yuanheng Guo, Guoqiang Chen, Dayong Li, Haijun Liu, Kejia Xu, Anni Liu, Bo Chen, Tai An, Xiaoyan Wang, Chao Peng, Xuemei Shen, Jin Tao, Lida Wu, Kai Yang, Qiong Wu
  • Patent number: 11155830
    Abstract: The present invention discloses preparation and use of a nanoparticle-doped RNA hydrogel targeting to a triple negative breast cancer (TNBC). The RNA hydrogel is a pure RNA system formed in a rolling circle transcription manner. The transcription process generates a large number of GC bonds, which provides a large number of sites for the introduction of DOX. The large number of RNA copy structures generated by rolling circle replication is a polyanionic aggregate. Due to the strong electronegativity of the polyanionic aggregate, electropositive MnO2@Ce6 nanoparticles are introduced, such that the colloid cationic MnO2@Ce6 particles can be stabilized by the polyanionic hydrogel, and thus target into a breast cancer cell for synergistic treatment. It can be used for a drug slow release system, has good biocompatibility, and has broad prospects in the fields of growth inhibition effects on targeted MDA-MB-231 tumor cells, inhibition of cancer metastasis and recurrence, and the like.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: October 26, 2021
    Assignee: LINYI UNIVERSITY
    Inventors: Xuemei Li, Xiaofan Liu, Lairong Ding, Shusheng Zhang
  • Publication number: 20210260046
    Abstract: The present invention relates to a pharmaceutical composition containing ilaprazole or a salt thereof, and a preparation method therefor. The pharmaceutical composition contains or consists of ilaprazole or a salt thereof, and a ilaprazole derivative, wherein the amount of the ilaprazole derivative in the pharmaceutical composition is not higher than 1.3 wt % (less than or equal to 1.3 wt %). The composition can be used for treating peptic ulcer bleeding and stress ulcer and preventing upper gastrointestinal hemorrhage caused by severe diseases.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 26, 2021
    Inventors: Tao WANG, Xuemei HOU, Caihua CHENG, Wenqi LU, Xiangsheng KONG, Xiangna ZHANG, Zengqing TU, Yurong ZHANG, Xiaohong WU, Jing LI, Hongdan CHEN, Jialu CHEN
  • Patent number: 11098319
    Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 24, 2021
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
  • Patent number: 10933310
    Abstract: A method for controlling a virtual character, a apparatus for controlling a virtual character, an electronic device and a computer-readable storage medium, the method including: in response to a first touch operation acted on an aiming control, adjusting a visual field mode of the game scene from a first visual field mode to a second visual field mode; presenting a first shooting control on the GUI under the condition of the second visual field mode, the first shooting control and the aiming control being located at two sides of the GUI, respectively; and in response to a second touch operation acted on the first shooting control, controlling the virtual character to perform a shooting action.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: March 2, 2021
    Assignee: NETEASE (HANGZHOU) NETWORK CO., LTD.
    Inventor: Xuemei Li
  • Publication number: 20210047364
    Abstract: The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ?O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ?O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.
    Type: Application
    Filed: October 15, 2020
    Publication date: February 18, 2021
    Inventors: Zhenwen Duan, Shuren Guo, Xuemei Li
  • Publication number: 20210024570
    Abstract: The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ?O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ?O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.
    Type: Application
    Filed: October 15, 2020
    Publication date: January 28, 2021
    Inventors: Zhenwen Duan, Shuren Guo, Xuemei Li
  • Publication number: 20210017537
    Abstract: The present invention discloses preparation and use of a nanoparticle-doped RNA hydrogel targeting to a triple negative breast cancer (TNBC). The RNA hydrogel is a pure RNA system formed in a rolling circle transcription manner. The transcription process generates a large number of GC bonds, which provides a large number of sites for the introduction of DOX. The large number of RNA copy structures generated by rolling circle replication is a polyanionic aggregate. Due to the strong electronegativity of the polyanionic aggregate, electropositive MnO2@Ce6 nanoparticles are introduced, such that the colloid cationic MnO2@Ce6 particles can be stabilized by the polyanionic hydrogel, and thus target into a breast cancer cell for synergistic treatment. It can be used for a drug slow release system, has good biocompatibility, and has broad prospects in the fields of growth inhibition effects on targeted MDA-MB-231 tumor cells, inhibition of cancer metastasis and recurrence, and the like.
    Type: Application
    Filed: March 20, 2020
    Publication date: January 21, 2021
    Inventors: Xuemei LI, Xiaofan LIU, Lairong DING, Shusheng ZHANG
  • Patent number: 10889612
    Abstract: The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ?O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ?O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.
    Type: Grant
    Filed: December 25, 2012
    Date of Patent: January 12, 2021
    Assignee: Beijing Peking University WBL Biotech Co., Ltd.
    Inventors: Zhenwen Duan, Shuren Guo, Xuemei Li
  • Patent number: 10765947
    Abstract: The present disclosure provides a visual display method and apparatus for compensating sound information, a storage medium, and an electronic device, and relates to the field of human-computer interaction technology. The visual display method includes: providing a mini-map on a graphical user interface, and rendering a first graphic identifier on the mini-map, wherein the first graphic identifier is used to indicate a current position and orientation of a virtual object in a game scene; detecting a sound in a first preset range of the game scene, and when the sound in the first preset range of the game scene is detected, acquiring orientation information of a sound source of the sound; and generating a second graphic identifier corresponding to the sound at a corresponding position on the mini-map according to the orientation information of the sound source of the sound.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: September 8, 2020
    Assignee: NETEASE (HANGZHOU) NETWORK CO., LTD.
    Inventor: Xuemei Li
  • Publication number: 20200222797
    Abstract: A method for controlling a virtual character, a apparatus for controlling a virtual character, an electronic device and a computer-readable storage medium, the method including: in response to a first touch operation acted on an aiming control, adjusting a visual field mode of the game scene from a first visual field mode to a second visual field mode; presenting a first shooting control on the GUI under the condition of the second visual field mode, the first shooting control and the aiming control being located at two sides of the GUI, respectively; and in response to a second touch operation acted on the first shooting control, controlling the virtual character to perform a shooting action.
    Type: Application
    Filed: March 31, 2020
    Publication date: July 16, 2020
    Applicant: NETEASE (HANGZHOU) NETWORK CO.,LTD.
    Inventor: Xuemei LI
  • Publication number: 20200032284
    Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.
    Type: Application
    Filed: October 11, 2019
    Publication date: January 30, 2020
    Applicant: Agrivida, Inc.
    Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
  • Patent number: 10500484
    Abstract: An information processing method and apparatus, a storage medium, and an electronic device are provided. The method includes that: a motion control is provided in a graphical user interface, a first touch operation acting on the motion control is detected, and a virtual character is controlled to move in a game scene according to a movement of a touch point of the first touch operation; an orientation control area is provided, a second touch operation acting on the orientation control area is detected, and an orientation of the virtual character in the game scene is adjusted according to a movement of a touch point of the second touch operation; and a perspective control is provided, a third touch operation acting on the perspective control is detected, and a presentation perspective of the game scene is adjusted according to the third touch operation.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: December 10, 2019
    Assignee: NETEASE (HANGZHOU) NETWORK CO., LTD.
    Inventor: Xuemei Li
  • Patent number: 10494640
    Abstract: Methods and compositions are described for producing a glucanase in transgenic plants and then incorporating parts of the transgenic plants in animal feed. The feed glucanase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Producing the enzyme in the transgenic plant enhances the thermal stability of the enzyme.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: December 3, 2019
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Xuemei Li
  • Patent number: 10364106
    Abstract: A stopping device for a conveying process of an object and a conveyor system are provided. The stopping device includes: a pedestal; a driving structure rotatably connected to the pedestal through a first spindle; a stopping arm rotatably connected to the pedestal through a second spindle; and a linkage rod connected between the driving structure and the stopping arm. The driving structure is configured to drive the linkage rod to move, so that the linkage rod drives the stopping arm to rotate about the second spindle between a first position and a second position.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: July 30, 2019
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., BEIJING BOE DISPLAY TECHNOLOGY CO., LTD.
    Inventors: Peng Di, Lizhu Yu, Hongtao Ma, Xuemei Li, Qi Chen, Wei Zhao
  • Publication number: 20190126151
    Abstract: The present disclosure provides a visual display method and apparatus for compensating sound information, a storage medium, and an electronic device, and relates to the field of human-computer interaction technology. The visual display method includes: providing a mini-map on a graphical user interface, and rendering a first graphic identifier on the mini-map, wherein the first graphic identifier is used to indicate a current position and orientation of a virtual object in a game scene; detecting a sound in a first preset range of the game scene, and when the sound in the first preset range of the game scene is detected, acquiring orientation information of a sound source of the sound; and generating a second graphic identifier corresponding to the sound at a corresponding position on the mini-map according to the orientation information of the sound source of the sound.
    Type: Application
    Filed: October 23, 2018
    Publication date: May 2, 2019
    Applicant: NETEASE (HANGZHOU) NETWORK CO.,LTD.
    Inventor: Xuemei LI
  • Publication number: 20190118078
    Abstract: An information processing method and apparatus, a storage medium, and an electronic device are provided. The method includes that: a motion control is provided in a graphical user interface, a first touch operation acting on the motion control is detected, and a virtual character is controlled to move in a game scene according to a movement of a touch point of the first touch operation; an orientation control area is provided, a second touch operation acting on the orientation control area is detected, and an orientation of the virtual character in the game scene is adjusted according to a movement of a touch point of the second touch operation; and a perspective control is provided, a third touch operation acting on the perspective control is detected, and a presentation perspective of the game scene is adjusted according to the third touch operation.
    Type: Application
    Filed: August 21, 2018
    Publication date: April 25, 2019
    Inventor: Xuemei LI
  • Publication number: 20190091561
    Abstract: A method for controlling a virtual character, a apparatus for controlling a virtual character, an electronic device and a computer-readable storage medium, the method including: in response to a first touch operation acted on an aiming control, adjusting a visual field mode of the game scene from a first visual field mode to a second visual field mode; presenting a first shooting control on the GUI under the condition of the second visual field mode, the first shooting control and the aiming control being located at two sides of the GUI, respectively; and in response to a second touch operation acted on the first shooting control, controlling the virtual character to perform a shooting action.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 28, 2019
    Applicant: NETEASE (HANGZHOU) NETWORK CO.,LTD.
    Inventor: Xuemei LI
  • Publication number: 20190023499
    Abstract: A stopping device for a conveying process of an object and a conveyor system are provided. The stopping device includes: a pedestal; a driving structure rotatably connected to the pedestal through a first spindle; a stopping arm rotatably connected to the pedestal through a second spindle; and a linkage rod connected between the driving structure and the stopping arm. The driving structure is configured to drive the linkage rod to move, so that the linkage rod drives the stopping arm to rotate about the second spindle between a first position and a second position.
    Type: Application
    Filed: January 24, 2017
    Publication date: January 24, 2019
    Applicants: BOE TECHNOLOGY GROUP CO., LTD., BEIJING BOE DISPLAY TECHNOLOGY CO., LTD.
    Inventors: Peng DI, Lizhu YU, Hongtao MA, Xuemei LI, Qi CHEN, Wei ZHAO
  • Publication number: 20180312900
    Abstract: Methods of increasing extraction of enzymes from animal feed and measuring enzyme activity are described herein.
    Type: Application
    Filed: May 20, 2016
    Publication date: November 1, 2018
    Applicant: AGRIVIDA, INC.
    Inventors: Xuemei LI, R. Michael RAAB