Abstract: The present disclosure relates to a quick tire self-centering clamp, including a clamp body assembly, a gear and rack transmission mechanism and a locking mechanism, where the clamp body assembly includes a seat body and three guide rails, each of the guide rails is provided with a sliding seat, and a gripping jaw for holding a tire tightly is fixed on the sliding seat; the gear and rack transmission mechanism includes three racks, one end of each of the racks is fixedly connected to the sliding seat and is parallel to the guide rail in opposite directions, a central shaft sleeve is mounted in the seat body, a gear is fixed on the central shaft sleeve; the locking mechanism includes a ratchet, a positioning pin rod and a positioning pin telescopic component. the gear and rack transmission mechanism can increase the adjustment stroke of the clamp.