Publication number: 20230295149
Abstract: A monobactam compound of formula (I), a preparation thereof, and a use thereof as antibiotic agents for the treatment of bacterial infections are provided. In the formula (I), M is hydrogen or a pharmaceutically acceptable salt forming cation, R1 and R2 represent independently of one another hydrogen or methyl, W represents a bond or O, X represents CR4 or N, R4 represents halogen, R3 represents hydrogen, amino, hydroxy, (C1-C6)-alkyl, or a 4-, 5- or 6-membered nitrogen-containing heterocycle.
Type:
Application
Filed:
July 16, 2020
Publication date:
September 21, 2023
Applicant:
NINGXIA ACADEMY OF AGRICULTURE AND FORESTRY SCIENCES
Inventors:
Zhixiang YANG, Haikang YANG, Jinbo JI, Lijuan ZHAI, Lili HE, Jian SUN, Koko MYO, Dong TANG, Yuanyu GAO, Yuanbai LIU, Yangxiu MU, Jingwen JI, Zafar IQBAL, Zawmin THU, Rui JIANG, Xueqin MA, Jianqiang YU
Publication number: 20230183208
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Application
Filed:
February 6, 2023
Publication date:
June 15, 2023
Applicant:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng Zhang, Wangwei Ao, Yuan Li, Hui Wang, Hangzhou Shen, Jie Ni, Huan Zhang, Jie Wu, Li Zhang, Kai Cao, Peng Lu, Xushi Liu, Jie Wang, Tianxiao Zhao, Xingfeng Ge, Dandan Lu, Shuo Chen, Xueqin Ma, Wei Shi, Xiaojin Wang, Hongjiang Xu
Patent number: 11597716
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Grant
Filed:
March 29, 2019
Date of Patent:
March 7, 2023
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng Zhang, Wangwei Ao, Yuan Li, Hui Wang, Hangzhou Shen, Jie Ni, Huan Zhang, Jie Wu, Li Zhang, Kai Cao, Peng Lu, Xushi Liu, Jie Wang, Tianxiao Zhao, Xingfeng Ge, Dandan Lu, Shuo Chen, Xueqin Ma, Wei Shi, Xiaojin Wang, Hongjiang Xu
Publication number: 20220185774
Abstract: Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.
Type:
Application
Filed:
September 27, 2019
Publication date:
June 16, 2022
Inventors:
Yinsheng ZHANG, Wangwei AO, Yuan LI, Hui WANG, Hangzhou SHEN, Jie NI, Huan ZHANG, Jie WU, Li ZHANG, Kai CAO, Peng LU, Xushi LIU, Jie WANG, Tianxiao ZHAO, Xingfeng GE, Dandan LU, Shuo CHEN, Xueqin MA, Wei SHI, Xiaojin WANG, Hongjiang XU
Publication number: 20210017154
Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.
Type:
Application
Filed:
March 29, 2019
Publication date:
January 21, 2021
Applicant:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors:
Yinsheng ZHANG, Wangwei AO, Yuan LI, Hui WANG, Hangzhou SHEN, Jie NI, Huan ZHANG, Jie WU, Li ZHANG, Kai CAO, Peng LU, Xushi LIU, Jie WANG, Tianxiao ZHAO, Xingfeng GE, Dandan LU, Shuo CHEN, Xueqin MA, Wei SHI, Xiaojin WANG, Hongjiang XU
Patent number: 8278437
Abstract: Hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin, the preparation method, analytical method, and the pharmaceutical application thereof. The hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin is a derivate of cyclodextrin which is substituted by hydroxypropyl group and sulfobutyl group: n-(2,3,6-O-2-hydroxypropyl)-m-(2,3,6-O-sulfobutyl)-&bgr;-cyclodextrin. The number of substituent groups per mole cyclodextrin is n hydroxypropyl groups and m sulfobutyl groups. “n” represents the average substituent degree of hydroxypropyl groups; “m” represents the average substituent degree of sulfobutyl groups; “n+m=z” is the gross average substituent degree, in which n is a random integer chosen from 1,2,3,4,5,6,7,8,9; m is a random integer chosen from 1,2,3,4,5,6,7,8,9; and the gross average substituent degree z is a random integer chosen from 2,3,4,5,6,7,8,9,10. The present invention shows low haemolysis and low toxicity.
Type:
Grant
Filed:
November 28, 2005
Date of Patent:
October 2, 2012
Assignee:
Hainan Hdeton Science and Technology Co. Ltd.
Inventors:
Yong Ren, Xueqin Ma, Shuqin Yu, Xiaodong Sun
Publication number: 20090012042
Abstract: Hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin, the preparation method, analytical method, and the pharmaceutical application thereof. The hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin is a derivate of cyclodextrin which is substituted by hydroxypropyl group and sulfobutyl group: n-(2,3,6-O-2-hydroxypropyl)-m-(2,3,6-O-sulfobutyl)-&bgr;-cyclodextrin. The number of substituent groups per mole cyclodextrin is n hydroxypropyl groups and m sulfobutyl groups. “n” represents the average substituent degree of hydroxypropyl groups; “m” represents the average substituent degree of sulfobutyl groups; “n+m=z” is the gross average substituent degree, in which n is a random integer chosen from 1, 2, 3, 4, 5, 6, 7, 8, 9; m is a random integer chosen from 1, 2, 3, 4, 5, 6, 7, 8, 9; and the gross average substituent degree z is a random integer chosen from 2, 3, 4, 5, 6, 7, 8, 9, 10. The present invention shows low haemolysis and low toxicity.
Type:
Application
Filed:
November 28, 2005
Publication date:
January 8, 2009
Applicant:
NANJING NORMAL UNIVERSITY
Inventors:
Yong Ren, Xueqin Ma, Shuqin Yu, Xiaodong Sun