Abstract: Described herein is a kinase inhibitor compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug of the compound. Further described herein is a pharmaceutical composition containing the kinase inhibitor compound, as well as methods of using the compound to inhibit cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGFR?, PDGFR?, and/or VEGFR2 kinase activity in cells or a subject, and methods for preventing or treating disorders related to cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGFR?, PDGFR?, and/or VEGFR2 activity in a subject.

Abstract: The present invention discloses an air-floating centrifugal compressor, including a motor, an impeller, an air inlet, an outlet port, and a connection pipe. The motor includes a housing and a rotor, a first chamber and a second chamber are arranged at two ends inside the housing, and an air-floating radial bearing is arranged on the rotor. The impeller is fixed to the end of the rotor and is located in the first chamber and/or the second chamber. The air inlet of the first chamber is connected to the air inlet, and the air outlet is connected to one end of the connecting pipe, the air outlet of the second chamber is connected to the outlet port, and the air inlet is connected to the other end of the connecting pipe.

Abstract: An energy storage thermal management system, comprising a refrigeration module and a cooling module, wherein the refrigeration module comprises an air-floating centrifugal compressor and a condenser. Wherein the air-floating centrifugal compressor is used for compressing a refrigerant to form a refrigerant in a first state, and an inlet of the condenser is connected to an exhaust port of the air-floating centrifugal compressor to cool down the refrigerant in the first state to form a refrigerant in a second state, and the temperature of the second state is lower than that of the first state but the pressure is the same. The cooling module is used for heat dissipation of the target equipment, and its inlet is connected with the outlet of the condenser, and its outlet is connected with the air inlet of the air-floating centrifugal compressor, and the inlet is arranged with a throttling element.

Abstract: This invention relates to methods of treating B-cell malignancies using a combination of inhibitors of JAK1 and/or JAK2 and inhibitors of PI3K?.

Abstract: The present invention a sparse optimization method based on cross-shaped three-dimensional imaging sonar array, comprising the following steps: first, constructing a beam pattern simultaneously applicable to a near field and a far field based on a cross-shaped array; then, constructing an energy function required by sparse optimization according to the beam pattern; then, introducing an array element position disturbance into a simulated annealing algorithm to increase the degree of freedom of the sparse process and increase the sparse rate of the sparse array, and using the simulated annealing algorithm to sparse optimization of the energy function; finally, after optimization, a sparse optimization cross-shaped array is obtained. The present invention ensures that the three-dimensional imaging sonar system has the desired performance at any distance, and greatly reduces the hardware complexity of the system.

Abstract: Provided arm IL15 constructs, a pharmaceutical composition comprising said IL15 constructs, and use of the IL15 constructs or the composition for treating a disease, such as cancer, infectious disease or an immune disorder.

Abstract: A coil inductor includes a first conductive coil, a second conductive coil, a third conductive coil, a first insulation film, and a second insulation film. The first insulation film is disposed on the first conductive coil, and the first insulation film includes at least one first through hole. The second conductive coil is disposed on the first insulation film. The second insulation film is disposed on the second conductive coil, and the second insulation film includes at least one second through hole unaligned with the first through hole. The third conductive coil is disposed on the second insulation film. The first conductive coil is in electric contact with the second conductive coil through a first contact disposed in the first through hole, and the second conductive coil is in electric contact with the third conductive coil through a second contact disposed in the second through hole.

Abstract: The present invention discloses a ViBe-based three-dimensional sonar point cloud image segmentation method, characterized by including: (1) acquiring sonar data, and converting three-dimensional sonar depth image data corresponding to each frame of the sonar data to point cloud data under an orthogonal coordinate system; (2) sampling the point cloud data, and down-sampling the point cloud data to a plurality of adjacent voxels with side length being R by taking a variable resolution R as a function; (3) carrying out image segmentation on the down-sampled point cloud data by a ViBe algorithm; (4) carrying out accumulative scoring on each voxel according to an image segmentation result, and sorting foreground data and background data according to accumulative score; and (5) clustering the foreground data, and then carrying out expansion operation on the foreground data by taking an original point in the voxel as a center to obtain final foreground point cloud data.

Abstract: The present invention had disclosed an embedded processor based 3D acoustic imaging real-time signal processing device of modularized design; the system comprises an embedded GPU signal processing subsystem, a signal interaction subsystem and a signal acquisition subsystem. The system takes Tegra K1 embedded GPU processor as the core; Tegra K1 embedded GPU processor is provided with features of OpenGL4.4, OpenGL ES 3.1 and CUDA, which has high parallel image processing capability and abundant high-speed data interconnection interface; it is especially applicable to high-speed data transmission and effective calculation of image algorithm for 3D acoustic imaging real-time signal processing device. Meanwhile, it can realize high-speed data interaction between signal processing subsystem and numerous signal acquisition subsystems; the whole system has powerful data interaction capability and real-time parallel processing capability.

Abstract: The present invention relates to a kinase inhibitor, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention further relates to pharmaceutical compositions comprising the kinase inhibitor, as well as to using said compounds and compositions to inhibit cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGF, PDGF, and/or VEGFR2 kinase activity in cells or a subject, and/or to a use and method for preventing or treating disorders related to cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGF, PDGF, and/or VEGFR2 activity in a subject.

Abstract: The present invention discloses a point cloud mean background subtraction based method for 3D sonar image modeling, comprising: (1) obtaining sonar data, and convert 3D sonar range image information corresponding to sonar data per frame into point cloud data for overall coordinate; such point cloud data will form image pixels; (2) taking the mean value u(x,y,z) of pixels at the same position in a series sequential frame images as pixels at the same position in the background model to obtain the background model; define threshold value TH for background standard based on pixel in each image; (3) testing current frame image I(x,y,z) based on background model and threshold value TH to obtain output image; (4) using current frame image I(x,y,z) to update background model and threshold value TH.

Abstract: The present invention relates to the field of security technology, and in particular to a fine granularity real-time supervision system based on edge computing. A fine granularity real-time supervision system based on edge computing is provided, comprising: an intelligent video monitoring device, an edge computing module, an edge computing node, and a cloud computing center. The system can reduce the redundant information of the system and realizes fine granularity management.

Abstract: The present invention discloses a distance statistics based method for 3D sonar point cloud image enhancement, comprising the following steps: (1) obtaining sonar data, and converting 3D sonar range image information corresponding to sonar data per frame into point cloud data in global coordinate; (2) using a kd-tree to search the point cloud data, and calculate Euclidean distance Lij between point Pi and the nearest K point cloud data; wherein, value range of i and j is 1?i?N and 1?j?K respectively; N refers to the total quantity of point cloud data; (3) excluding point cloud data corresponding to mean value of Lij which do not match the certain Gaussian distribution, and complete enhancement of 3D sonar point cloud image. Such method features in easy operation, high efficiency and convenience, which can effectively remove outlier points to minimize noise, and enhance point cloud image.

Abstract: The present invention discloses a point cloud mean background subtraction based method for 3D sonar image modeling, comprising: (1) obtaining sonar data, and convert 3D sonar range image information corresponding to sonar data per frame into point cloud data for overall coordinate; such point cloud data will form image pixels; (2) taking the mean value u(x, y, z) of pixels at the same position in a series sequential frame images as pixels at the same position in the background model to obtain the background model; define threshold value TH for background standard based on pixel in each image; (3) testing current frame image I(x, y, z) based on background model and threshold value TH to obtain output image; (4) using current frame image I(x, y, z) to update background model and threshold value TH.

Abstract: The present invention a sparse optimization method based on cross-shaped three-dimensional imaging sonar array, comprising the following steps: first, constructing a beam pattern simultaneously applicable to a near field and a far field based on a cross-shaped array; then, constructing an energy function required by sparse optimization according to the beam pattern; then, introducing an array element position disturbance into a simulated annealing algorithm to increase the degree of freedom of the sparse process and increase the sparse rate of the sparse array, and using the simulated annealing algorithm to sparse optimization of the energy function; finally, after optimization, a sparse optimization cross-shaped array is obtained. The present invention ensures that the three-dimensional imaging sonar system has the desired performance at any distance, and greatly reduces the hardware complexity of the system.

Abstract: The present invention discloses a distance statistics based method for 3D sonar point cloud image enhancement, comprising the following steps: (1) obtaining sonar data, and converting 3D sonar range image information corresponding to sonar data per frame into point cloud data in global coordinate; (2) using a kd-tree to search the point cloud data, and calculate Euclidean distance Lij between point Pi and the nearest K point cloud data; wherein, value range of i and j is 1?i?N and 1?j?K respectively; N refers to the total quantity of point cloud data; (3) excluding point cloud data corresponding to mean value of Lij which do not match the certain Gaussian distribution, and complete enhancement of 3D sonar point cloud image. Such method features in easy operation, high efficiency and convenience, which can effectively remove outlier points to minimize noise, and enhance point cloud image.

Abstract: The present invention relates to the field of security technology, and in particular to a fine granularity real-time supervision system based on edge computing. A fine granularity real-time supervision system based on edge computing is provided, comprising: an intelligent video monitoring device, an edge computing module, an edge computing node, and a cloud computing center. The system can reduce the redundant information of the system and realizes fine granularity management.

Abstract: This invention relates to methods of treating B-cell malignancies using a combination of inhibitors of JAK1 and/or JAK2 and inhibitors of PI3K?.

Abstract: The present invention discloses a ViBe-based three-dimensional sonar point cloud image segmentation method, characterized by including: (1) acquiring sonar data, and converting three-dimensional sonar depth image data corresponding to each frame of the sonar data to point cloud data under an orthogonal coordinate system; (2) sampling the point cloud data, and down-sampling the point cloud data to a plurality of adjacent voxels with side length being R by taking a variable resolution R as a function; (3) carrying out image segmentation on the down-sampled point cloud data by a ViBe algorithm; (4) carrying out accumulative scoring on each voxel according to an image segmentation result, and sorting foreground data and background data according to accumulative score; and (5) clustering the foreground data, and then carrying out expansion operation on the foreground data by taking an original point in the voxel as a center to obtain final foreground point cloud data.

Abstract: A process knowledge system for traditional Chinese medicine production includes a database module having production data acquisition and storage units. The production data acquisition unit acquires process parameter data in production. The parameter data includes quality and process data and is stored in the storage unit. A capability evaluation module evaluates the process capability of the system according to the quality data to obtain a process capability evaluation result. A monitoring feedback module enters a whole-process monitoring mode the process capability is found sufficient. A design space searching module enters a design space searching mode when the process capability is found insufficient.