Abstract: This invention revealed the preparative method and applications of a Zn(II)-curcumin complex and its solid dispersions. The mass ration of Zn(II)-curcumin complex and polyvinylpyrrolidone (PVP) K30 was 1:1˜1:28. The Zn(II)-curcumin complex was synthesized by mixing equimolar amounts of zinc acetate and curcumin in dry ethanol and refluxing the mixture under a nitrogen atmosphere. The Zn(II)-curcumin complex precipitated, and the solid was separated by filtration and washed several times by water and ethanol to remove any unreacted curcumin and zinc acetate. Zn(II)-curcumin and PVP-k30 were added to absolute ethanol to produce a suspension by cryo-grinding under a nitrogen atmosphere. SDs of Zn(II)-curcumin/PVP were produced with a spray dryer. Zn(II)-curcumin SDs showed predominant effects in curing various senile diseases by tackling disadvantages of curcumin and surmounted the problems of monoindication and unideal therapeutic efficacy general existed in drugs for senile disease treatment.

Abstract: This invention revealed the preparative method and applications of a Zn(II)-curcumin complex and its solid dispersions. The mass ration of Zn(II)-curcumin complex and polyvinylpyrrolidone (PVP) K30 was 1:1˜1:28. The Zn(II)-curcumin complex was synthesized by mixing equimolar amounts of zinc acetate and curcumin in dry ethanol and refluxing the mixture under a nitrogen atmosphere. The Zn(II)-curcumin complex precipitated, and the solid was separated by filtration and washed several times by water and ethanol to remove any unreacted curcumin and zinc acetate. Zn(II)-curcumin and PVP-k30 were added to absolute ethanol to produce a suspension by cryo-grinding under a nitrogen atmosphere. SDs of Zn(II)-curcumin/PVP were produced with a spray dryer. Zn(II)-curcumin SDs showed predominant effects in curing various senile diseases by tackling disadvantages of curcumin and surmounted the problems of monoindication and unideal therapeutic efficacy general existed in drugs for senile disease treatment.