Patents by Inventor Xufeng Sun
Xufeng Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230043305Abstract: This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of for advantageous therapeutic pharmaceutical efficacy and dosage form stability.Type: ApplicationFiled: February 28, 2022Publication date: February 9, 2023Applicant: G1 Therapeutics, Inc.Inventors: Alexander Smith, Hannah S. White, Patricia Andres, Xufeng Sun, Lei Zhu, Petinka I. Vlahova
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Patent number: 11457628Abstract: The present invention discloses a substituted pyrimidine compound. The structure is shown in general formula I. The definition of each substituent in the formula is described in the description. The compound of the present invention has broad-spectrum fungicidal, insecticidal and acaricidal activity, and has excellent control effects on cucumber downy mildew, powdery mildew, corn rust, anthrax, rice blast, aphids, Tetranychus cinnabarinus and the like.Type: GrantFiled: November 22, 2018Date of Patent: October 4, 2022Assignees: SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD., JIANGSU YANGNONG CHEMICAL CO., LTD.Inventors: Aiying Guan, Miao Li, Junfeng Wang, Leichuan Xu, Qin Sun, Xufeng Sun, Jinqiang Sun, Changling Liu
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Patent number: 11261193Abstract: This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of for advantageous therapeutic pharmaceutical efficacy and dosage form stability.Type: GrantFiled: December 19, 2019Date of Patent: March 1, 2022Assignee: GI Therapeutics, Inc.Inventors: Alexander Smith, Hannah S. White, Patricia Andres, Xufeng Sun, Lei Zhu, Petinka I. Vlahova
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Patent number: 11008339Abstract: Disclosed are substituted pyrazole compounds containing pyrimidinyl as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a good spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, rice blast, cucumber anthracnosis and the like. The compounds of present invention also show good insecticidal activity.Type: GrantFiled: May 17, 2016Date of Patent: May 18, 2021Assignee: Shenyang Sinochem Agrochemicals R&D Co., Ltd.Inventors: Changling Liu, Aiying Guan, Junfeng Wang, Xufeng Sun, Zhinian Li, Jinbo Zhang, Lanfeng Ban, Sen Ma, Jie Lan, Xiaoli Xia, Jinlong Yang
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Publication number: 20210015100Abstract: The present invention discloses a substituted pyrimidine compound. The structure is shown in general formula I. The definition of each substituent in the formula is described in the description. The compound of the present invention has broad-spectrum fungicidal, insecticidal and acaricidal activity, and has excellent control effects on cucumber downy mildew, powdery mildew, corn rust, anthrax, rice blast, aphids, Tetranychus cinnabarinus and the like.Type: ApplicationFiled: November 22, 2018Publication date: January 21, 2021Applicant: SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.Inventors: Aiying GUAN, Miao LI, Junfeng WANG, Leichuan XU, Qin SUN, Xufeng SUN, Jinqiang SUN, Changling LIU
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Publication number: 20200123168Abstract: This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of 2?-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7?,8?-dihydro-6?H-spiro[cyclohexane-1,9?-pyrazino[1?,2?:1,5]pyrrolo[2,3-d]pyrimidin]-6?-one for advantageous therapeutic pharmaceutical efficacy and dosage form stability.Type: ApplicationFiled: December 19, 2019Publication date: April 23, 2020Applicant: G1 Therapeutics, Inc.Inventors: Alexander Smith, Hannah S. White, Patrica Andres, Xufeng Sun, Lei Zhu, Petinka I. Vlahova
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Patent number: 10519176Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: GrantFiled: November 2, 2017Date of Patent: December 31, 2019Assignee: THAR PHARMA, LLCInventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Paul K. Isbester, Xufeng Sun
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Publication number: 20190002483Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: ApplicationFiled: November 2, 2017Publication date: January 3, 2019Applicant: GRUNENTHAL GMBHInventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Paul K. ISBESTER, Xufeng SUN
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Patent number: 9988370Abstract: Salts of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid are disclosed. More particularly, salt forms (HCl-salt, HBr-salt, p-toluenesulfonate salt and ethanedisulfonate salt) are disclosed. Furthermore, processes for the preparation of such salt forms, compositions containing such salt forms, and uses of such salt forms are disclosed. A method of treating disease conditions mediated by 5-HT4 receptor activity includes administering an effective amount of such salt forms to an animal, including a human, in need of such treatment.Type: GrantFiled: May 20, 2015Date of Patent: June 5, 2018Assignee: RaQualia Pharma Inc.Inventors: Toyoharu Numata, Masaki Sudo, Xufeng Sun
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Publication number: 20180141961Abstract: Disclosed are substituted pyrazole compounds containing pyrimidinyl as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a good spectrum of bactericidal, insecticidal and acaricidal activity,and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, rice blast, cucumber anthracnosis and the like. The compounds of present invention also show good insecticidal activity.Type: ApplicationFiled: May 17, 2016Publication date: May 24, 2018Inventors: Changling Liu, Aiying Guan, Junfeng Wang, Xufeng Sun, Zhinian Li, Jinbo Zhang, Lanfeng Ban, Sen Ma, Jie Lan, Xiaoli Xia, Jinlong Yang
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Patent number: 9920045Abstract: The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.Type: GrantFiled: November 4, 2016Date of Patent: March 20, 2018Assignee: Omeros CorporationInventors: Ekaterina Albert, Jennifer Leigh Nelson, Christopher Scott Seadeek, Karl Reineke, Marco Jonas, Suba Iyer, Xufeng Sun, Neil S. Cutshall, Jennifer Lynn Gage, Thomas L. Little, Wayne Douglas Luke, Elisabeth C. A. Brot, Michael James McDermott
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Patent number: 9770026Abstract: Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.Type: GrantFiled: October 24, 2013Date of Patent: September 26, 2017Assignee: Shenyang Sinochem Agrochemicals R&D Co., Ltd.Inventors: Changling Liu, Lizeng Wang, Yuquan Song, Xufeng Sun, Jie Lan, Aiying Guan, Junfeng Wang, Jinbo Zhang, Cong Feng, Minna Zhu, Zhinian Li, Lanhui Ren, Xiuhui Chang, Fan Yang, Qin Sun, Wei Chen, Shaowu Liu, Yinping Zhou, Zhonggang Shan, Baoshan Chai, Bin Wang, Jizhong Zhou
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Patent number: 9682962Abstract: Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by Plutella xylostella, armyworm, Myzus persicae, Tetranychus cinnabarinus etc.Type: GrantFiled: December 11, 2014Date of Patent: June 20, 2017Assignee: Shenyang Sinochem Agrochemicals R&D CO., LTD.Inventors: Changling Liu, Xufeng Sun, Jie Zhao, Lizeng Wang, Keke Li, Jinbo Zhang, Xuanming Chen, Aiying Guan, Yuquan Song, Jie Lan, Sen Ma, Lijun Ru
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Publication number: 20170166559Abstract: The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.Type: ApplicationFiled: November 4, 2016Publication date: June 15, 2017Inventors: Ekaterina Albert, Jennifer Leigh Nelson, Christopher Scott Seadeek, Karl Reineke, Marco Jonas, Suba Iyer, Xufeng Sun, Neil S. Cutshall, Jennifer Lynn Gage, Thomas L. Little, Wayne Douglas Luke, Elisabeth C. A. Brot, Michael James McDermott
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Publication number: 20170081318Abstract: Salts of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid are disclosed. More particularly, salt forms (HCl-salt, HBr-salt, p-toluenesulfonate salt and ethanedisulfonate salt) are disclosed. Furthermore, processes for the preparation of such salt forms, compositions containing such salt forms, and uses of such salt forms are disclosed. A method of treating disease conditions mediated by 5-HT4 receptor activity includes administering an effective amount of such salt forms to an animal, including a human, in need of such treatment.Type: ApplicationFiled: May 20, 2015Publication date: March 23, 2017Applicant: RaQualia Pharma Inc.Inventors: Toyoharu Numata, Masaki Sudo, Xufeng Sun
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Publication number: 20170022225Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: ApplicationFiled: April 15, 2016Publication date: January 26, 2017Inventors: Mazen HANNA, Ning SHAN, Miranda L. CHENEY, David R. WEYNA, Paul K. ISBESTER, Xufeng SUN
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Publication number: 20160332991Abstract: Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by Plutella xylostella, armyworm, Myzus persicae, Tetranychus cinnabarinus etc.Type: ApplicationFiled: December 11, 2014Publication date: November 17, 2016Applicant: SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.Inventors: Changling LIU, Xufeng SUN, Jie ZHAO, Lizeng WANG, Keke LI, Jinbo ZHANG, Xuanming CHEN, Aiying GUAN, Yuquan SONG, Jie LAN, Sen MA, Lijun RU
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Patent number: 9340565Abstract: Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.Type: GrantFiled: November 23, 2011Date of Patent: May 17, 2016Assignee: THAR PHARMACEUTICALS, INC.Inventors: Mazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Paul K. Isbester, Xufeng Sun
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Publication number: 20150257385Abstract: Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY. See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.Type: ApplicationFiled: October 24, 2013Publication date: September 17, 2015Inventors: Changling Liu, Lizeng Wang, Yuquan Song, Xufeng Sun, Jie Lan, Aiying Guan, Junfeng Wang, Jinbo Zhang, Cong Feng, Minna Zhu, Zhinian Li, Lanhui Ren, Xiuhui Chang, Fan Yang, Qin Sun, Wei Chen, Shaowu Liu, Yinping Zhou, Zhonggang Shan, Baoshan Chai, Bin Wang, Jizhong Zhou
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Patent number: D772291Type: GrantFiled: August 14, 2014Date of Patent: November 22, 2016Assignee: Tencent Technology (Shenzhen) Company LimitedInventors: Jinrui Nie, Yongjun Wang, Xiang Li, Kangle Zeng, Xinggang Li, Xufeng Sun, Yinze Zhang, Xueyong Zheng, Dongdong Xing, Xi Chen, Yumei Cui, Dongxue Zhao, Na Chen