Abstract: The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLpro activity, and is useful in the preparation of a SARS-CoV-2 3CLpro inhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLpro inhibitors and anti-SARS-CoV-2 drugs.

Abstract: A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.

Abstract: A live broadcast method and apparatus, an electronic device, and a storage medium, including: receiving a pre live broadcast request sent by a second device by means of a live broadcast account; based on the live broadcast account, determining a corresponding first live broadcast record and acquiring a live broadcast state from the first live broadcast record; when the live broadcast state is a live state, sending a first live broadcast parameter to the live broadcast account of the second device, the first live broadcast parameter corresponding to a first live broadcast identifier; receiving a live broadcast start request corresponding to the first live broadcast parameter sent by the second device by means of the live broadcast account; and sending a first live broadcast start command carrying the first live broadcast identifier to the live broadcast account of the second device.

Abstract: A live broadcast method and apparatus, an electronic device, and a storage medium, including: receiving a pre live broadcast request sent by a second device by means of a live broadcast account; based on the live broadcast account, determining a corresponding first live broadcast record and acquiring a live broadcast state from the first live broadcast record; when the live broadcast state is a live state, sending a first live broadcast parameter to the live broadcast account of the second device, the first live broadcast parameter corresponding to a first live broadcast identifier; receiving a live broadcast start request corresponding to the first live broadcast parameter sent by the second device by means of the live broadcast account; and sending a first live broadcast start command carrying the first live broadcast identifier to the live broadcast account of the second device.

Abstract: A method for determining a media server and a sever are provided. In the method, a live streaming access request from a target account is received; an audience number type of an anchor account in the live streaming room is determined; a target media server matching the audience number type is determined; and a live video stream in the live streaming room is transmitted, based on the target media server, to a terminal from which the target account is logged in.

Abstract: The present disclosure relates to a method, apparatus and system for configuring a task goal of a live stream. The method comprises: receiving a task goal configuration instruction for a specified task of live stream; in response to the task goal configuration instruction, determining candidate task goals according to historical data representing a task goal of the specified task; using the candidate task goals as optional configuration items, and displaying same on a task goal configuration interface of a live stream client; and in response to a selection operation for the optional items, configuring the task goal of the specified task. Also disclosed are an apparatus and system for configuring a live stream task goal, and an electronic device and a computer-readable storage medium. The technical solution provided by the present disclosure can solve the problem in the art of low efficiency in configuring a task goal.

Abstract: A method for determining a media server and a sever are provided. In the method, a live streaming access request from a target account is received; an audience number type of an anchor account in the live streaming room is determined; a target media server matching the audience number type is determined; and a live video stream in the live streaming room is transmitted, based on the target media server, to a terminal from which the target account is logged in.