Patents by Inventor Xuhuang Tu

Xuhuang Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF
    Publication number: 20210024499
    Abstract: Disclosed herein are compounds capable of inducing apoptosis through promoting Nur77 interaction with Bcl-2 and through modulating mitochondrial activities. Also disclosed herein are compositions and methods using these compounds and compositions. Nur77 is a key regulator of Bcl-2 activities and is capable of converting Bcl-2 from an anti-apoptotic protein to a pro-apoptotic protein. Small molecules that directly modulate the Nur77/Bc1-2 apoptotic pathways are promising for treating diseases with abnormal levels of Bcl-2, Nur77, or combinations thereof, including cancers.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Inventors: Xiaokun Zhang, Ying Su, Xihua Cao, Xuhuang Tu, Xiaohui Chen, Zhiping Zeng