Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: The present disclosure relates to compositions and methods relating to chimeric antigen receptor (CAR) polypeptides and methods relating thereto. In one embodiment, the present disclosure relates to engineered cells having chimeric antigen receptor polypeptides directed to at least two targets. In another embodiment, the present disclosure relates to engineered cells having chimeric antigen receptor polypeptides and an enhancer moiety.

Abstract: An apparatus configured to measure electromagnetic radiation coupled from an image sensor integrated circuit (IC) to a nearby cell phone antenna has an image sensor PCB with the image sensor IC on a first side and image sensor decoupling capacitors disposed on a second side, the image sensor PCB disposed within a shielding box. The apparatus also has an image processor PCB with an image processor IC on a first side and at least one image processor decoupling capacitors, the image processor IC electrically coupled to the image sensor IC. The image processor IC is located outside the shielding box, and the at least one image processor decoupling capacitor is within the shielding box. In embodiments, the decoupling capacitors are shielded with separate, additional, metal covers.

Abstract: In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first co-stimulatory domain, and a first signaling domain; and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co-stimulatory domain, and a second signaling domain; wherein the first antigen recognition domain is different than the second antigen recognition domain.

Abstract: The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: This disclosure relates to chimeric antigen receptors targeting T cell malignancies. The present disclosure also relates to the development of methods for inactivation with engineered CARs, to enhance T cell functions or reduce T cell suppression.

Abstract: The present invention relates to compositions and methods relating to chimeric antigen receptor (CAR) polypeptides and methods relating thereto. In one embodiment, the present invention relates to engineered cells having chimeric antigen receptor polypeptides directed to at least two targets. In another embodiment, the present invention relates to engineered cells having chimeric antigen receptor polypeptides and an enhancer moiety.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: A contrast ratio improving device includes a controller and a photo detector. A contrast ratio improving method for use with a display panel includes the following steps. Firstly, multiple voltage values are applied to the display panel. Then, the brightness values corresponding to the voltage values applied to the display panel are detected. Afterwards, a voltage value corresponding to a specified value of the brightness values is selected as a peak voltage of the display panel. An image display system is also provided. The image display system includes a display panel and a memory. The memory stores a peak voltage obtained by the contrast ratio improving method.

Abstract: A liquid crystal display (LCD) device is provided. The LCD device includes a LCD panel, which further includes a plurality of scan lines, a gate driving circuit, a clock circuit. The clock circuit includes a clock generator and an adjusting circuit. The clock generator generates a clock signal having a first high voltage level and a first low voltage level. The adjusting circuit, coupled to the clock generator, receives the clock signal and generates an adjusted clock signal having the same period as the clock signal. The adjusted clock signal has a second high voltage level and a second low voltage level. The gate driving circuit, coupled to the clock circuit, receives the adjusted clock signal as a gate driving signal in order to drive the scan lines.

Abstract: A flat display and a method for modulating a clock signal for driving a flat display are provided. The flat display includes a clock generator and a clock modulator. The clock generator provides a clock signal that includes at least a first cycle waveform and a second cycle waveform following said first cycle waveform. The first cycle waveform is modulated by the clock modulator as a first modulated cycle waveform divided by a first positive modulated cycle waveform and a first negative modulated cycle waveform, and the second cycle waveform is modulated as a second modulated cycle waveform divided by a second positive modulated cycle waveform and a second negative modulated cycle waveform. The first positive modulated cycle waveform and the first negative modulated cycle waveform have a first duration difference, and the second positive modulated cycle waveform and the second negative modulated cycle waveform have a second duration difference different from the first duration difference.

Abstract: A contrast ratio improving device includes a controller and a photo detector. A contrast ratio improving method for use with a display panel includes the following steps. Firstly, multiple voltage values are applied to the display panel. Then, the brightness values corresponding to the voltage values applied to the display panel are detected. Afterwards, a voltage value corresponding to a specified value of the brightness values is selected as a peak voltage of the display panel. An image display system is also provided. The image display system includes a display panel and a memory. The memory stores a peak voltage obtained by the contrast ratio improving method.

Abstract: A liquid crystal display (LCD) device is provided. The LCD device includes a LCD panel, which further includes a plurality of scan lines, a gate driving circuit, a clock circuit. The clock circuit includes a clock generator and an adjusting circuit. The clock generator generates a clock signal having a first high voltage level and a first low voltage level. The adjusting circuit, coupled to the clock generator, receives the clock signal and generates an adjusted clock signal having the same period as the clock signal. The adjusted clock signal has a second high voltage level and a second low voltage level. The gate driving circuit, coupled to the clock circuit, receives the adjusted clock signal as a gate driving signal in order to drive the scan lines.

Abstract: A flat display and a method for modulating a clock signal for driving a flat display are provided. The flat display includes a clock generator and a clock modulator. The clock generator provides a clock signal that includes at least a first cycle waveform and a second cycle waveform following said first cycle waveform. The first cycle waveform is modulated by the clock modulator as a first modulated cycle waveform divided by a first positive modulated cycle waveform and a first negative modulated cycle waveform, and the second cycle waveform is modulated as a second modulated cycle waveform divided by a second positive modulated cycle waveform and a second negative modulated cycle waveform. The first positive modulated cycle waveform and the first negative modulated cycle waveform have a first duration difference, and the second positive modulated cycle waveform and the second negative modulated cycle waveform have a second duration difference different from the first duration difference.

Abstract: A control method for a display panel including a plurality of pixel units arranged in a matrix is disclosed. A plurality of video signals are received. A sequence of the video signals and a preset arrangement are compared. When the sequence of the video signals differs from the preset arrangement, polarities are provided to the video signals by a first inversion method for generating a plurality of first data signals. When the sequence of the video signals corresponds to the preset arrangement, polarities are provided to the video signals by a second inversion method for generating a plurality of second data signals. The second data signals are output to the pixel units.

Abstract: A handlebar assembly for bicycles includes a connection bar having a first end securely mounted to a steerer tube and a recess is defined in a second end of the connection bar. A positioning cap has a concavity defined in an underside thereof and is securely connected to the second end of the connection bar. A pad is connected to an inside of the concavity of the positioning cap and a handlebar is securely engaged with the concavity of the positioning cap and the recess of the connection bar. Bolts extend through the positioning cap, the pad and are threadedly engaged with threaded holes defined in the connection bar.

Abstract: A combination of a bearing journal assembly and a head tube of a bicycle includes a skirt extending from each of two ends of the head tube and each skirt has a groove defined therein. A retainer has a plurality of balls rotatably engaged therewith as a one-piece member which is engaged with the groove in each skirt.