Abstract: A tablet comprises a granulate of an active pharmaceutical ingredient comprising at least one cannabinoid having a melting point less than about 80° C.; sugar, sugar alcohol, or a combination thereof; microcrystalline cellulose having an average particle size less than about 25 ?m; silica, silicified microcrystalline cellulose, or a combination thereof; and lubricant comprising sodium stearyl fumarate and lecithin. Methods of forming such a tablet using direct compression of a tablet formulation can be conducted on a large manufacturing scale.

Abstract: A method for formulating an active pharmaceutical ingredient (API) comprises mixing the API and micronized polymer matrix particles comprising polymer strands and having a mean geometric particle diameter in a range of from about 0.1 to about 100 microns, wherein the API is in a liquid phase, to form a homogeneous slurry, allowing the polymer matrix particles to absorb the API, and drying the slurry to form a composite material. The composite material facilitates formation of a tablet or other solid unit dosage form containing the API and/or improves dissolution of the API, for example, in vivo.

Abstract: Methods of making a dry powder, comprise (a) delivering a liquid solution or suspension and a second, immiscible fluid to a flow path, (b) transporting the liquid solution or suspension and the immiscible fluid along the flow path, wherein the flow path includes two or more flow passages of different diameters, at least one flow divider which divides and diverts the flowing mixture into at least two separate passages, wherein the separate passages subsequently intersect to combine their respective flows into a single flowing stream, (c) rapidly reducing the pressure of the single flowing stream, whereby droplets are formed, and (d) passing the droplets through a flow of inert drying gas to form a dry powder. A nebulizing nozzle includes an inlet, a flow path as described, and a restrictor nozzle outlet.

Abstract: Methods of making a dry powder, comprise (a) delivering a liquid solution or suspension and a second, immiscible fluid to a flow path, (b) transporting the liquid solution or suspension and the immiscible fluid along the flow path, wherein the flow path includes two or more flow passages of different diameters, at least one flow divider which divides and diverts the flowing mixture into at least two separate passages, wherein the separate passages subsequently intersect to combine their respective flows into a single flowing stream, (c) rapidly reducing the pressure of the single flowing stream, whereby droplets are formed, and (d) passing the droplets through a flow of inert drying gas to form a dry powder. A nebulizing nozzle includes an inlet, a flow path as described, and a restrictor nozzle outlet.