Patents by Inventor Xunpei Liu

Xunpei Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240415850
    Abstract: Corticosteroid compositions including a corticosteroid drug substance (e.g., fluocinolone, fluocinolone acetonide, dexamethasone, dexamethasone phosphate, dexamethasone sodium phosphate, triamcinolone, and triamcinolone acetonide) or a or a salt or derivative thereof and one or more irregular-shaped particulate fatty acid or keto-enol tautomer complexation agents admixed in a dispersal medium, having a release profile with one or more phases of drug release. These compositions are extended release corticosteroid compositions may release a clinically useful level of corticosteroid for more than 1 to 12 months within the body. Also described herein are methods of forming and methods of using these compositions.
    Type: Application
    Filed: November 18, 2022
    Publication date: December 19, 2024
    Inventors: Andres GARCIA, Xunpei LIU
  • Publication number: 20240269320
    Abstract: Described herein are therapeutic compositions and methods of use, for the delivery of various drug substances, in and around the eye, comprising: a drug substance, noncovalently interacting with one or more complexation agent particulates to form drug substance-complex particulates, admixed within a hydrophobic dispersal medium, that collectively forms a stable multiphasic colloidal suspension, that serves as an extended release drug delivery system for ocular drug delivery. Formulation of the drug substance in the multiphasic colloidal suspension can be administered in and around the eye to produce sustained release of therapeutic levels of drug substance within ocular tissues for one or more months without requiring retreatment.
    Type: Application
    Filed: June 1, 2022
    Publication date: August 15, 2024
    Inventors: Andres GARCIA, Xunpei LIU
  • Publication number: 20240269292
    Abstract: Described herein are therapeutic compositions for the treatment of mitochondrial disorders, and in particular mitochondrial disorders of the eye, including age-related macular degeneration (AMD). In particular, described herein are prodrugs of mitochondrial targeted tetrapeptides that have a cleavable covalent bond (e.g., an ester bond) to a conjugation moiety, wherein the conjugation moiety of the prodrug noncovalently complexes with one or more complexation agents to form drug-complex particulates with a defined avidity, and one or more drug-complex particulates are added to and dispersed within a dispersal medium forming a multiphasic colloidal suspension that serves as an extended release drug delivery system for ocular drug delivery. This extended release drug delivery system may be injected or inserted into the eye (e.g., vitreous) to reverse and prevent mitochondrial dysfunction in the eye for one or more months without requiring retreatment.
    Type: Application
    Filed: June 1, 2022
    Publication date: August 15, 2024
    Inventors: Andres GARCIA, Xunpei LIU
  • Patent number: 10442982
    Abstract: To deliver surfactants or tracers to underground oil fields, inorganic encapsulated surfactant nanoparticles or microparticles that are stable for several weeks under high temperature and high salt conditions can be used.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 15, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Angela M. Belcher, Nurxat Nuraje, Yu Lei, Hiroshi Atsumi, Xunpei Liu
  • Publication number: 20160340569
    Abstract: To deliver surfactants or tracers to underground oil fields, inorganic encapsulated surfactant nanoparticles or microparticles that are stable for several weeks under high temperature and high salt conditions can be used.
    Type: Application
    Filed: May 20, 2016
    Publication date: November 24, 2016
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Angela M. Belcher, Nurxat Nuraje, Yu Lei, Hiroshi Atsumi, Xunpei Liu