Patents by Inventor Xuntian JIANG

Xuntian JIANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bile acid biomarkers for Niemann-Pick diseases, methods and uses therefor
    Patent number: 10983112
    Abstract: Methods for identification and quantification of bile acids are disclosed. Bile acids in plasma, serum and/or blood such as a dried blood spot are used to identify subjects with a Niemann-Pick disease. The methods include measuring levels of a bile acid, such as 3?,5?,6?-trihydroxycholanic acid, N-(3?,5?,6?-trihydroxy-cholan-24-oyl)glycine, N-(3?,5?,6?-trihydroxy-cholan-24-oyl)taurine, or a combination thereof. Detection of bile acids involve mass spectroscopy and/or a combination of mass spectroscopy and liquid chromatography such as a LC-MS/MS assay. The methods can be used with sphingomyelinase assays to detect, diagnose and differentiate between Niemann-Pick A/B and Niemann-Pick C (NPC) disease.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: April 20, 2021
    Assignee: Washington University
    Inventors: Daniel Ory, Xuntian Jiang
  • METHODS OF DETECTING CERAMIDE
    Publication number: 20180306797
    Abstract: Among the various aspects of the present disclosure is the provision of a method of detecting ceramides as prognostic indicators. An aspect of the present disclosure provides for a prognostic indicator for risk of developing a cardiovascular-related disease, disorder, or condition and mortality risk.
    Type: Application
    Filed: April 24, 2018
    Publication date: October 25, 2018
    Inventors: Jean E. Schaffer, Daniel S. Ory, Linda R. Peterson, Xuntian Jiang, Vasan S. Ramachandran, Vanessa Xanthakis, Meredith S. Duncan
  • BILE ACID BIOMARKERS FOR NIEMANN-PICK DISEASES, METHODS AND USES THEREFOR
    Publication number: 20170285015
    Abstract: Methods for identification and quantification of bile acids are disclosed. Bile acids in plasma, serum and/or blood such as a dried blood spot are used to identify subjects with a Niemann-Pick disease. The methods include measuring levels of a bile acid, such as 3?,5?,6?-trihydroxycholanic acid, N-(3?,5?,6?-trihydroxy-cholan-24-oyl)glycine, N-(3?,5?,6?-trihydroxy-cholan-24-oyl)taurine, or a combination thereof. Detection of bile acids involve mass spectroscopy and/or a combination of mass spectroscopy and liquid chromatography such as a LC-MS/MS assay. The methods can be used with sphingomyelinase assays to detect, diagnose and differentiate between Niemann-Pick A/B and Niemann-Pick C (NPC) disease.
    Type: Application
    Filed: April 28, 2017
    Publication date: October 5, 2017
    Applicant: Washington University
    Inventors: Daniel ORY, Xuntian JIANG