Patents by Inventor Xuqing Zhang

Xuqing Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANOL ANTAGONISTS OF CCR2
    Publication number: 20100144695
    Abstract: The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, and R4 are as defined in the specification. The invention also comprises pharmaceutical compositions comprising the compounds of formula (I) and methods of preventing, treating or ameliorating a CCR2 mediated syndrome, disorder or disease, for example, type II diabetes, obesity or asthma, by administering the compounds of formula (I).
    Type: Application
    Filed: December 9, 2009
    Publication date: June 10, 2010
    Inventors: Xuqing Zhang, Heather Rae Hufnagel, Cuifen Hou, Dana L. Johnson, Zhihua Sui, Barry Fegely, David Breslin
  • NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
    Publication number: 20100144823
    Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Application
    Filed: February 17, 2010
    Publication date: June 10, 2010
    Inventors: James C. Lantar, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
  • Indole derivatives as selective androgen receptor modulators (SARMS)
    Patent number: 7705147
    Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: April 27, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: James C. Lanter, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
  • Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
    Patent number: 7696239
    Abstract: The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: April 13, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Zhihua Sui, Xuqing Zhang, Xiaojie Li
  • Indole derivatives as selective androgen receptor modulators (SARMS)
    Patent number: 7678926
    Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: March 16, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: James C. Lanter, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
  • Tricyclic dihydropyrazines as potassium channel openers
    Patent number: 7674793
    Abstract: The present invention is directed to novel tricyclic dihydropyrazine derivatives of Formula (I), pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: March 9, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Xuqing Zhang, Zhihua Sui
  • Imidazolopyrazole derivatives useful as selective androgen receptor modulators
    Patent number: 7655683
    Abstract: The present invention is directed to novel imidazolopyrazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: February 2, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Xuqing Zhang, Zhihua Sui
  • Bicyclic heterocycles useful as selective androgen receptor modulators
    Patent number: 7626036
    Abstract: The present invention is directed to novel bicyclic heterocycles, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: December 1, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Xuqing Zhang, Zhihua Sui
  • NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
    Publication number: 20090216023
    Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Application
    Filed: August 8, 2008
    Publication date: August 27, 2009
    Inventors: James C. Lanter, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
  • NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
    Publication number: 20090131365
    Abstract: The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Application
    Filed: May 27, 2008
    Publication date: May 21, 2009
    Inventors: Xuqing Zhang, Xiaojie Li, Zhihua Sui
  • Novel Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors
    Publication number: 20090069362
    Abstract: The present invention is directed to novel spiro-benzo[C]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Application
    Filed: November 11, 2008
    Publication date: March 12, 2009
    Inventors: Xuqing Zhang, Zhihua Sui
  • Heterocycle derivatives useful as selective androgen receptor modulators (SARMs)
    Patent number: 7465809
    Abstract: The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: December 16, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Xuqing Zhang, Xiaojie Li, Zhihua Sui
  • Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors
    Patent number: 7452914
    Abstract: The present invention is directed to novel spiro-benzo[C]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: November 18, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Xuqing Zhang, Zhihua Sui
  • Indole derivatives as selective androgen receptor modulators (SARMS)
    Patent number: 7427682
    Abstract: The present invention is directed to novel insole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: September 23, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: James C. Lanter, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
  • NOVEL HETEROCYCLIC BENZO[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS
    Publication number: 20080221125
    Abstract: The present invention is directed to novel heterocyclic benzo[c]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Application
    Filed: May 21, 2008
    Publication date: September 11, 2008
    Inventors: Xuqing Zhang, Xiaojie Li, Zhihua Sui
  • Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors
    Patent number: 7399767
    Abstract: The present invention is directed to novel heterocyclic benzo[c]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: July 15, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Xuqing Zhang, Xiaojie Li, Zhihua Sui
  • NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS
    Publication number: 20080114048
    Abstract: The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.
    Type: Application
    Filed: January 3, 2008
    Publication date: May 15, 2008
    Inventors: Zhihua SUI, Xuqing ZHANG, Xiaojie LI
  • NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)
    Publication number: 20080070970
    Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Application
    Filed: September 20, 2007
    Publication date: March 20, 2008
    Inventors: James Lanter, Zhihua Sui, James Fiordeliso, Weiqin Jiang, Xuqing Zhang
  • Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
    Patent number: 7338973
    Abstract: The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: March 4, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Zhihua Sui, Xuqing Zhang, Xiaojie Li
  • Indole derivatives as selective androgen receptor modulator (SARMS)
    Patent number: 7288553
    Abstract: The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: October 30, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: James C. Lanter, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang