Patents by Inventor Xusha Zhou

Xusha Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXOSOMES CONTAINING MIRNAS TARGETING HER2 SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20230398144
    Abstract: Disclosed is an engineered exosome comprising a miRNA targeting human epidermal growth factor receptor 2 (HER2) synthesis and a ligand displayed on a membrane of the exosome for specific binding to a HER2 protein expressed on a cancer cell.
    Type: Application
    Filed: October 25, 2021
    Publication date: December 14, 2023
    Inventors: Xiaoqing CHEN, Lei WANG, Xusha ZHOU, Grace Guoying ZHOU
  • PHARMACEUTICAL COMPOSITIONS, KITS AND METHODS FOR TREATING TUMORS
    Publication number: 20220347243
    Abstract: Provided is a composition for treating tumors in a subject comprising a therapeutically effective amount of an exosome carrying CTLA4-targeting miRNA and a therapeutically effective amount of an oncolytic herpes simplex virus expressing an immunostimulatory agent or both an immunostimulatory agent and an anti-PD-1 antibody. Wherein an exo-motif operably links to the seed sequence of the CTLA4-targeting miRNA to enhance the packaging of the CTLA4-targeting miRNA into the exosome.
    Type: Application
    Filed: July 4, 2019
    Publication date: November 3, 2022
    Inventors: Xiaoqing Chen, Xusha Zhou, Bernard Roizman, Grace Guoying Zhou