Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly the homogeneous assay that does not use the step of wash and that is fast (e.g. 60 seconds from dropping a sample to displaying results).

Abstract: The disclosure provides a kit and method using the kit for analyzing a sample, particularly blood. The kit may comprise a device (a) for sample collecting, mixing, staining, and transferring and a device (b) for sample distribution and imaging device. The device (a) comprises part (1) and an optional part (2) connected to each other. The part (1) is a capillary tube with reagent coated inside. The part (2) is used for providing an external force to suck in and/or push out the sample. The device (b) comprises two plates opposing to each other and defining an interior cavity, and a sample inlet. The interior cavity is in fluid communication with the exterior liquid sample contact area. The liquid sample flows into the spacing between the two plates through the sample inlet and a sample landing Zone that is at the exterior location of the device (b).

Abstract: Disclosed are devices, kits, apparatus, and methods for rapid homogenous cell staining and imaging.

Abstract: The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.

Abstract: The present invention provides, among other things, QMAX card based assays in different forms for various analytes, offering simpler, fast, more sensitive assaying.

Abstract: A mixed reality system that includes a device and a base station that communicate via a wireless connection The device may include sensors that collect information about the user's environment and about the user. The information collected by the sensors may be transmitted to the base station via the wireless connection. The base station renders frames or slices based at least in part on the sensor information received from the device, encodes the frames or slices, and transmits the compressed frames or slices to the device for decoding and display. The base station may provide more computing power than conventional stand-alone systems, and the wireless connection does not tether the device to the base station as in conventional tethered systems. The system may implement methods and apparatus to maintain a target frame rate through the wireless link and to minimize latency in frame rendering, transmittal, and display.

Abstract: A device and system for changing the temperature of a fluidic sample includes a first plate and a second plate movable relative to each other into an open configuration and a closed configuration, and spacers having a uniform height. The plates include a sample contact area for contacting the sample and have a configuration for changing the temperature of the sample. In the open configuration the plates are separated, and the sample is capable of being deposited onto the plates. In the closed configuration, the plates are parallel, the plates compress the sample into a layer of uniform thickness that is stagnant relative to the plates, the layer is confined by the sample contact areas of the plates and is regulated by the plates and the spacers, and the plates are configured to change the temperature of the sample at a rate of at least 10° C./sec.

Abstract: Among other things, the present invention is related to bio/chemical sampling, sensing, assays and applications.

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

Abstract: A device may include a display for displaying an image frame based on warped image data and image processing circuitry to generate the warped image data by warping input image data to account for one or more distortions associated with displaying the image. The image processing circuitry may include a two-stage cache architecture having an first cache and an second cache and warp the input image data by generating mapping data indicative of a warp between the input image space and the output image space and fetching the input image data to populate the first cache. Warping may also include populating the second cache with a grouping of pixel values from the first cache that are selected according to a sliding window that traverses the first cache based on the mapping data and interpolating between pixel values of the grouping to generate pixel values of the warped image data.

Abstract: A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.

Abstract: Some embodiments of the invention provide methods that can create large area complex patterns for nanoimprint molds without or with very litter of the use of the charged beam or photon beam direct-writing of nanostructures. Some embodiments of the invention use (i) Fourier nanoimprint patterning (FNP), (ii) edge-guided nanopatterning (EGN), and (iii) nanostructure self-perfection, and their combinations.

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

Abstract: A mixed reality system that includes a device and a base station that communicate via a wireless connection The device may include sensors that collect information about the user's environment and about the user. The information collected by the sensors may be transmitted to the base station via the wireless connection. The base station renders frames or slices based at least in part on the sensor information received from the device, encodes the frames or slices, and transmits the compressed frames or slices to the device for decoding and display. The base station may provide more computing power than conventional stand-alone systems, and the wireless connection does not tether the device to the base station as in conventional tethered systems. The system may implement methods and apparatus to maintain a target frame rate through the wireless link and to minimize latency in frame rendering, transmittal, and display.

Abstract: The disclosure provides a device and method for rapidly changing temperatures of a sample. An example of the device include: a first plate; a second plate; and a heating/cooling layer disposed on either the first or second plate. The first plate and the second plate face each other and are configured to receive a fluid sample sandwiched therebetween. The method includes depositing the fluid sample on one or both of the two plates, pressing the plates to form a thin layer of the sample, and changing and/or maintaining the temperature of the sample. The device or method can be used in, for example, PCR.

Abstract: The present invention provides, among other things, QMAX card based assays in different forms for various analytes, offering simpler, fast, more sensitive assaying.

Abstract: The present invention, among other things, provides the devices and methods in manipulate a sample for the purpose of assaying.

Abstract: The disclosure provides a device and a method to press a QMAX-Card to form a liquid layer. A device comprises a first arm including a pressing block and a second arm including a compartment for accommodating the QMAX-Card. Each of the first arm and the second arm comprises a first end and a second end opposing the first end, and the first arm and the second arm are joined by a hinge at the first end. The first arm is capable of rotating around the hinge toward the second arm 500 from an open position to a close position. The pressing block and the compartment face each other and are disposed at the second end. The pressing block press the QMAX-Card so that the QMAX-Card changes a closed configuration to compress a liquid sample in the QMAX-Card into a substantially uniform thin layer.

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.