Patents by Inventor Y. Esther Tak

Y. Esther Tak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducible, Tunable, and Multiplex Human Gene Regulation Using CRISPR-Cpf1
    Publication number: 20230416310
    Abstract: Drug-inducible, tunable, and multiplexable Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella 1 (Cpf1)-based activators, and methods of use thereof.
    Type: Application
    Filed: April 20, 2023
    Publication date: December 28, 2023
    Inventors: Y. Esther Tak, Benjamin Kleinstiver, J. Keith Joung
  • Systems and Methods for Stable and Heritable Alteration by Precision Editing (SHAPE)
    Publication number: 20230245716
    Abstract: Described herein are systems, methods, and compositions for the precise editing of DNA sequence(s) at specific loci to alter expression of target gene products at the pre-transcriptional or post-transcriptional level in a durable fashion, termed Stable and Heritable Alteration by Precision Editing (SHAPE). The SHAPE platform utilizes genetic modifiers (e.g., nucleases, (CRISPR guided) transposases, recombinases, base editors, and prime editors) to install specific sequence motifs at target sequences through precision genome engineering.
    Type: Application
    Filed: May 28, 2021
    Publication date: August 3, 2023
    Inventors: J. Keith Joung, Luca Pinello, Jonathan Hsu, Julian Grunewald, Y. Esther Tak, Md Nafiz Hamid
  • Inducible, tunable, and multiplex human gene regulation using CRISPR-Cpf1
    Patent number: 11667677
    Abstract: Drug-inducible, tunable, and multiplexable Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella 1 (Cpf1)-based activators, and methods of use thereof.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: June 6, 2023
    Assignee: The General Hospital Corporation
    Inventors: Y. Esther Tak, Benjamin Kleinstiver, J. Keith Joung
  • SYSTEM AND METHOD FOR ACTIVATING GENE EXPRESSION
    Publication number: 20230036273
    Abstract: Provided herein are artificial transcription factor systems and related methods for modulating gene expression.
    Type: Application
    Filed: November 25, 2020
    Publication date: February 2, 2023
    Inventors: J. Keith Joung, Y. Esther Tak