Abstract: Provided herein are pharmaceutical compositions and tissue/organ preservation solutions comprising itaconate and/or derivatives thereof and methods of use thereof. In particular, provided herein are compositions comprising itaconate and methods of use thereof for the preservation of tissues/organs for transplantation and treatment/prevention/reduction of conditions such as myocardial infarction, sudden cardiac arrest, stroke, senescence, cardiomyopathies, and cardiotoxicity.

Abstract: An method of creating a physical layout of an integrated circuit. A schematic file (600) is mapped directly to a physical layout using the location of elements and routing of interconnections as specified in the schematic file (600). The method takes advantage of constraints on the schematic design to provide the layout file (675) quickly, without complex routing programs. Design rules violations are anticipated and corrected in some cases. In other cases, the design rule violations are annotated, if the designer intentionally placed them in the design.

Abstract: A method of automatically generating a custom device layout includes the step of specifying a device type and an associated set of device parameters. The device type is then matched to a selected cell in a cell library. Physical layout regions of the selected cell are then selectively modified in accordance with the device parameters. The physical layout regions may also be selectively modified in accordance with technology design rules in a design rule library. The physical layout regions of the selected cell are then drawn.