Patents by Inventor Y. Lam

Y. Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240120096
    Abstract: A computational method, apparatus and system for diagnostic and therapeutic prediction from multimodal data is provided for using machine learning to predict medical therapeutic methods using multimodal data. The computational method, apparatus and system for diagnostic and therapeutic prediction from multimodal data may include a biomarker and subtype identification aspect, multimodality aspect, machine learning aspect, and training aspect. A method for using machine learning to predict medical therapeutic methods, which may include targets, drugs, or combinations of drugs, using multimodal data using the computational system for diagnostic and therapeutic prediction from multimodal data is also provided.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 11, 2024
    Inventors: Bayo Lau, Ashley Sylvia Lee, Tarsus Thomas Lam, Paul Merrill, Hugo Y.K. Lam
  • Patent number: 11155764
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes greater than 50 wt. % of a base oil of lubricating viscosity, calcium, nitrogen, molybdenum and boron. The weight ratio of Ca:N (ppm/ppm) in the lubricating oil composition is greater than 1.3 to less than 3.0, the weight ratio of Ca:Mo (ppm/ppm) in the lubricating oil composition is greater than 6.7 to less than 56.3, and the weight ratio of Ca:B (ppm/ppm) in the lubricating oil composition is greater than 5.0 to less than 9.8. The lubricating oil composition does not contain added magnesium from a magnesium-containing detergent. The lubricating oil composition is resistant to deposit formation in the boosted internal combustion engine, as shown by its ability to ensure a TCO Temperature Increase of less than 9.0% as measured using the 2015 version of the General Motors dexos1® Turbocharger Coking Test.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: October 26, 2021
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Kongsheng Yang, Kristin Fletcher, William Y. Lam, Jeremy Styer
  • Patent number: 10550349
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes a major amount of a base oil, one or more overbased calcium-containing detergents having a total base number of greater than 225 mg KOH/gram, to provide greater than 900 ppm by weight to less than 2400 ppm by weight of calcium to the lubricating oil composition, and a low speed pre-ignition reducing amount of one or more titanium-containing compounds to provide from 10 ppm to 3000 ppm titanium and/or one or more tungsten-containing compounds to provide from 125 ppm to 3000 ppm tungsten, all based on the total weight of the lubricating composition. The low speed pre-ignition events in the boosted internal combustion engine may be reduced relative to a number of low speed pre-ignition events in the same engine lubricated with the same lubricating oil without the titanium- and/or tungsten-containing additive.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: February 4, 2020
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Publication number: 20190330555
    Abstract: A lubricating oil composition including greater than 50 wt. % of a base oil, from 100 ppm to less than 1800 ppm by weight of total metal from metal-containing detergent(s) including an overbased calcium detergent and a magnesium containing detergent. The composition has a total nitrogen of 900 ppm to less than 1600 ppm by weight, and a ratio of total metal from the detergent(s) in ppm to the total nitrogen in ppm of less than 1.9. The composition also includes a borated compound to provide greater than 50 ppm by weight to 1000 ppm by weight of boron, and a ppm ratio of metal from the detergent(s) in ppm to the total boron is less than 7.5 and a molybdenum compound to provide greater than 80 ppm to 1200 ppm by weight molybdenum and a ppm ratio of total metal from the detergent(s) to the molybdenum is less than 23.8.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Applicant: Afton Chemical Corporation
    Inventors: Kongsheng Yang, Kristin Fletcher, William Y. Lam, Jeremy Styer
  • Patent number: 10421922
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes greater than 50 wt. % of a base oil, one or more overbased calcium-containing detergents having a TBN greater than 225 mg KOH/g and one or more magnesium-containing detergents. A total amount of calcium from the one or more overbased calcium-containing detergents is from 900 ppm to less than 2400 ppm by weight, and a total amount of magnesium from the one or more magnesium-containing detergents is from 50 ppm to 500 ppm by weight, both based on a total weight of the lubricating oil composition. The lubricating oil composition and the method of using it are effective to reduce low speed pre-ignition events in a boosted internal combustion engine lubricated with the lubricating oil composition.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: September 24, 2019
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Patent number: 10377963
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition is formulated to be resistant to turbocharger deposit formation in the boosted internal combustion engine, as shown by its ability to ensure a TCO Temperature Increase of less than 9.0% as measured using the 2015 version of the General Motors Dexos1® Turbocharger Coking Test. The lubricating oil composition may also have a low NOACK volatility, as measured by the method of ASTM D-5800 at 250° C.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: August 13, 2019
    Assignee: Afton Chemical Corporation
    Inventors: Kongsheng Yang, Kristin Fletcher, William Y. Lam, Jeremy Styer
  • Patent number: 10336959
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes greater than 50 wt. % of a base oil, an overbased detergent having a TBN greater than 225 mg KOH/g and a low-based/neutral detergent having a TBN up to 175 mg KOH/g. A total amount of calcium from the overbased and low-based/neutral detergent is greater than 1100 ppm to less than 2400 ppm by weight based on a total weight of the lubricating oil composition. The lubricating oil composition and method may be effective to reduce low-speed pre-ignition events in a boosted internal combustion engine lubricated with the lubricating oil composition relative to commercially available lubricating oil compositions.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: July 2, 2019
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Publication number: 20190197457
    Abstract: During operation, the system obtains a set of tickets to be processed at the customer-support ticketing system, wherein each ticket is tagged with any required skills, which are required to respond to the ticket. The system then enables an agent to request tickets to process, wherein a data structure representing the agent is tagged with any skills possessed by the agent. In response to the request, the system selects a matching subset of the set of tickets to be processed, wherein the matching subset comprises tickets for which the agent possesses a superset of the required skills that the ticket is tagged with. Next, the system presents the matching subset of tickets to the agent through a UI. Finally, the system enables the agent to operate the UI to: select a ticket from the matching subset of the set of tickets to be processed; and respond to an associated customer request.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 27, 2019
    Applicant: Zendesk, Inc.
    Inventors: Louis J. Chan, Joshua Y. Lam, Craig A. Little, Austin Wang, Michael Erik Smedberg, Kristen L. Mirenda
  • Patent number: 10323205
    Abstract: A method for reducing timing chain stretch in an engine comprising a step of lubricating said timing chain with a lubricating oil composition that includes a major amount of a base oil; and a minor amount of an additive package including (a) at least one overbased calcium detergent, (b) at least one borated dispersant, (c) a metal dialkyl dithiophosphate, and (d) at least one molybdenum compound. The lubricating oil composition has a TBN value of at least 7.5 mg KOH/g of the lubricating oil composition, at least 80 ppm of molybdenum, based on the total weight of the lubricating oil composition, a weight ratio of total calcium in the lubricating oil composition to total molybdenum in the lubricating oil composition of less than 8.4; and a weight ratio of nitrogen from the dispersant in the lubricating composition to total boron in the lubricating oil composition of from 2.6 to 3.0.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: June 18, 2019
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Kristin Fletcher, William Y. Lam
  • Patent number: 10280383
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition has not more than 150 ppm sodium and includes a major amount of a base oil and an additive composition that includes one or more overbased calcium-containing detergents having a total base number of greater than 225 mg KOH/gram, in an amount sufficient to provide greater than 1100 ppm by weight to less than 2400 ppm by weight of calcium to the lubricating oil composition, and one or more molybdenum-containing compounds in an amount sufficient to provide at least about 80 ppm by weight molybdenum to the lubricating oil composition, all based on the total weight of the lubricating composition. The oil and method may reduce low-speed pre-ignition events in the boosted internal combustion engine relative to a number of low-speed pre-ignition events in the same engine lubricated with a reference lubricating oil.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: May 7, 2019
    Assignee: Afton Chemical Corporation
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Patent number: 10214703
    Abstract: A lubricating oil composition and method of for providing an acceptable number of low-speed pre-ignition events in a boosted internal combustion engine using the lubricating oil composition. The lubricating oil composition includes greater than 50 wt. % of a base oil of lubricating viscosity, and an additive composition that includes an overbased calcium-containing detergent having a TBN greater than 225 mg KOH/g, and one or more zinc dialkyl dithiophosphate compounds are derived from a molar ratio of secondary alcohol to primary alcohol of 20:100 to about 100:0 and have an average total carbon content of greater than 10 carbon atoms per mole of phosphorous. The lubricating oil compositions contains the overbased calcium-containing detergent in an amount to provide greater than 900 ppm to less than 2400 ppm by weight calcium, and at least 0.01 wt. % of the zinc dialkyl dithiophosphate, both amounts based on the total weight of the lubricating oil composition.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: February 26, 2019
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Publication number: 20170321146
    Abstract: A method for reducing timing chain stretch in an engine comprising a step of lubricating said timing chain with a lubricating oil composition that includes a major amount of a base oil; and a minor amount of an additive package including (a) at least one overbased calcium detergent, (b) at least one borated dispersant, (c) a metal dialkyl dithiophosphate, and (d) at least one molybdenum compound. The lubricating oil composition has a TBN value of at least 7.5 mg KOH/g of the lubricating oil composition, at least 80 ppm of molybdenum, based on the total weight of the lubricating oil composition, a weight ratio of total calcium in the lubricating oil composition to total molybdenum in the lubricating oil composition of less than 8.4; and a weight ratio of nitrogen from the dispersant in the lubricating composition to total boron in the lubricating oil composition of from 2.6 to 3.0.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 9, 2017
    Applicant: Afton Chemical Corporation
    Inventors: Kristin Fletcher, William Y. Lam
  • Publication number: 20170321145
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes greater than 50 wt. % of a base oil of lubricating viscosity, calcium, nitrogen, molybdenum and boron. The weight ratio of Ca:N (ppm/ppm) in the lubricating oil composition is greater than 1.3 to less than 3.0, the weight ratio of Ca:Mo (ppm/ppm) in the lubricating oil composition is greater than 6.7 to less than 56.3, and the weight ratio of Ca:B (ppm/ppm) in the lubricating oil composition is greater than 5.0 to less than 9.8. The lubricating oil composition does not contain added magnesium from a magnesium-containing detergent. The lubricating oil composition is resistant to deposit formation in the boosted internal combustion engine, as shown by its ability to ensure a TCO Temperature Increase of less than 9.0% as measured using the 2015 version of the General Motors dexos1® Turbocharger Coking Test.
    Type: Application
    Filed: January 18, 2017
    Publication date: November 9, 2017
    Inventors: Kongsheng Yang, Kristin Fletcher, William Y. Lam, Jeremy Styer
  • Publication number: 20170247627
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition is formulated to be resistant to turbocharger deposit formation in the boosted internal combustion engine, as shown by its ability to ensure a TCO Temperature Increase of less than 9.0% as measured using the 2015 version of the General Motors dexos1® Turbocharger Coking Test. The lubricating oil composition may also have a low NOACK volatility, as measured by the method of ASTM D-5800 at 250° C.
    Type: Application
    Filed: January 18, 2017
    Publication date: August 31, 2017
    Applicant: Afton Chemical Corporation
    Inventors: Kongsheng Yang, Kristin Fletcher, William Y. Lam, Jeremy Styer
  • Publication number: 20170168747
    Abstract: Embodiments are generally directed to intelligent memory support for platform reset operation. An embodiment of a memory module includes a memory module controller and one or more memory banks. The memory module controller is to perform one or more internal reset processes as required for the memory module, and is to support a plurality of host platform reset processes to synchronize with the host platform.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 15, 2017
    Inventors: Woojong Han, John V. Lovelace, Priscilla Y. Lam, Richard P. Mangold, Asher M. Altman, Shachi K. Thakkar
  • Patent number: 9663743
    Abstract: A lubricant composition, lubricant concentrate and method for reducing engine deposits. The composition and method include a base oil of lubricating viscosity; an organo-molybdenum compound; a deposition reducing amount of a reaction product of an alkyl-substituted dicarboxylic acid compound selected from the group consisting of alkyl-substituted dicarboxylic acids, alkyl-substituted dicarboxylic acid anhydrides, and mixtures thereof, and a basic salt of aminoguanidine, in an amount sufficient to provide a product rich in alkyl bis-3-amino-1,2,4-triazole; and optionally a phenate detergent. The lubricant composition and method provide engine deposits that are less than an amount of engine deposits in the absence of component (c) and/or optional component (d).
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: May 30, 2017
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Paul G. Griffin, Ian A. Bell, John T. Loper, William Y. Lam, Gregory H. Guinther
  • Patent number: 9575069
    Abstract: Compositions, methods and kits for labeling proteins and uses in reporter systems for detecting, quantifying and/or characterizing analytes.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: February 21, 2017
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Steven Menchen, Joe Y. Lam, Zhaochun Ma, Khairuzzaman Bashar Mullah
  • Publication number: 20170015926
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes greater than 50 wt. % of a base oil, an overbased detergent having a TBN greater than 225 mg KOH/g and a low-based/neutral detergent having a TBN up to 175 mg KOH/g. A total amount of calcium from the overbased and low-based/neutral detergent is greater than 1100 ppm to less than 2400 ppm by weight based on a total weight of the lubricating oil composition. The lubricating oil composition and method may be effective to reduce low-speed pre-ignition events in a boosted internal combustion engine lubricated with the lubricating oil composition relative to commercially available lubricating oil compositions.
    Type: Application
    Filed: May 5, 2016
    Publication date: January 19, 2017
    Applicant: Afton Chemical Corporation
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Publication number: 20170015928
    Abstract: A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition includes a major amount of a base oil, one or more overbased calcium-containing detergents having a total base number of greater than 225 mg KOH/gram, to provide greater than 900 ppm by weight to less than 2400 ppm by weight of calcium to the lubricating oil composition, and a low speed pre-ignition reducing amount of one or more titanium-containing compounds to provide from 10 ppm to 3000 ppm titanium and/or one or more tungsten-containing compounds to provide from 125 ppm to 3000 ppm tungsten, all based on the total weight of the lubricating composition. The low speed pre-ignition events in the boosted internal combustion engine may be reduced relative to a number of low speed pre-ignition events in the same engine lubricated with the same lubricating oil without the titanium- and/or tungsten-containing additive.
    Type: Application
    Filed: May 5, 2016
    Publication date: January 19, 2017
    Applicant: Afton Chemical Corporation
    Inventors: Kristin Fletcher, William Y. Lam, Kongsheng Yang, Jeremy Styer
  • Patent number: D935078
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: November 2, 2021
    Assignee: Energizer Brands, LLC
    Inventors: Sin Kwan Chan, Wai Hung Liu, Michael Jerome, H. Y. Lam