Abstract: Generally described, one or more aspects of the present application relate to enabling determination of a predicted surgical efficacy of a proposed surgical intervention and a predicted pattern of post-operative recovery for the patient. More specifically, the present disclosure provides a system that can analyze the patient data of a plurality of patients data, generate analytics data indicating the post-operative recovery of the plurality of patients, and store the analytics data in association with the biological traits of the patients and the types of surgical interventions that the patients had. Subsequently, the system can analyze the patient traits and activity data of a patient, and output, based on the previously generated analytics data, a prediction of how efficacious a given surgical intervention might be for that patient and/or how the patient might recover from the given surgical intervention.

Abstract: The invention relates to modulating the SIRP?-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRP? polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.

Abstract: A method for monitoring and/or controlling a biopharmaceutical process includes querying, based on a first spectral scan vector of the biopharmaceutical process, an observation database comprising observation data sets associated with past scans. Each of the observation data sets includes spectral data and a corresponding actual analytical measurement. Querying the observation database includes determining first parameters defining a set of distributions for the first spectral scan vector, and selecting as training data, from among the observation data sets, particular observation data sets based on (i) the first parameters and (ii) other parameters defining respective sets of distributions for the observation data sets. The method also includes calibrating, using the selected training data, a local model specific to the biopharmaceutical process.

Abstract: The system includes a modulatable illumination source configured to illuminate a surface of a sample disposed on a sample stage, a detector configured to detect illumination emanating from a surface of the sample, illumination optics configured to direct illumination from the modulatable illumination source to the surface of the sample, collection optics configured to direct illumination from the surface of the sample to the detector, and a modulation control system communicatively coupled to the modulatable illumination source, wherein the modulation control system is configured to modulate a drive current of the modulatable illumination source at a selected modulation frequency suitable for generating illumination having a selected coherence feature length. In addition, the present invention includes the time-sequential interleaving of outputs of multiple light sources to generate periodic pulse trains for use in multi-wavelength time-sequential optical metrology.

Abstract: Techniques are provided for x-ray sensing for intraoral tomography. A methodology implementing the techniques according to an embodiment includes detecting an x-ray pulse based on energy received at one or more pixels of a pixel array. The method also includes integrating the energy received at each of the pixels of the array of pixels, in response to the detection, wherein the energy received at each of the pixels is associated with the x-ray pulse. The method further includes multiplexing readouts of analog signals from the array of pixels into two or more parallel channels. The method further includes simultaneously converting (or otherwise in parallel) the analog signals of each of the channels into digital signals and storing the digital signals in memory as frames of data. The method may further include, for example, transmitting the frames of data from the memory, over a Universal Serial Bus, to an imaging system.

Abstract: A monolithic optical retarder formed from a monolithic prism may include an input face for receiving a light beam, an output face aligned with an optical axis of the light beam prior to entering the input face, and three or more reflection faces. The three or more reflection faces may be oriented to provide an optical path for the light beam from the input face to the output face via reflection by the three or more reflection faces, where the monolithic optical retarder imparts a selected optical retardation on the light beam based on total internal reflection on at least one of the reflection faces. Further, the input face, the output face, and the three or more reflection faces may be oriented such that an optical axis of the light beam exiting the output face is equal to the optical axis of the light beam entering the input face.

Abstract: Disclosed herein are related to systems and methods for providing inputs through a virtual keyboard with an adaptive language model. In one approach, one or more processors determine whether a user intended to provide semantically meaningful characters or not, when providing a hand motion or a hand pose with respect to a virtual keyboard. The virtual keyboard may be located on a surface without physical keys. In one approach, the one or more processors determine an input to the virtual keyboard based on the hand motion or the hand pose. In one approach, the one or more processors determine weight of a language model according to the determined user intention. In one approach, the one or more processors modify the detected input according to the determined weight of the language model.

Abstract: Techniques are provided for x-ray onset detection for an intraoral dental sensor. A methodology implementing the techniques according to an embodiment includes calculating a plurality of superpixel values for each of a plurality of rows of detector pixels of a sensor. Each of the superpixel values is based on a sum of pixel values of a set of pixels associated with the superpixel value, the set of pixels selected from the detection row of a current frame of the sensor. The method also includes calculating a difference between each of the superpixel values and a corresponding stored superpixel value generated from a previous sensor frame and determining if the differences exceed a superpixel threshold value. The method further includes incrementing a hit counter in response to the determination and generating a detection signal if the hit counter exceeds a hit count threshold, otherwise proceeding to process the next detection row.

Abstract: The present invention provides a method to consistently and continuously monitor an individual's ocular fundus via the acquisition of standardized fundus images longitudinally, especially for (but not limited to) individuals with diabetic retinopathy. Briefly, the key points of the present invention include: (a) using an aiming beam to target anatomic landmarks of the ocular fundus; (b) using normal anatomic landmarks as registration points; (c) providing a method of image acquisition to create standardized images.

Abstract: A method for detecting cytopathic effect (CPE) in a well sample includes generating a well image depicting a well containing cells and a medium (and possibly viruses), and pre-processing the well image at least by partitioning the well image into sub-images each corresponding to a different portion of the well. The method also includes, for each of some or all of the sub-images, determining, by analyzing the sub-image using a convolutional neural network, a respective score indicative of a likelihood that any cells in the portion of the well corresponding to the sub-image exhibit CPE. The method further includes determining a CPE status of the cells contained in the well based on the respective scores for the sub-images, and generating output data indicating the CPE status.

Abstract: A system for electrical energy production from chemical reagents in a compartmentalized cell includes: at least two electrodes, comprising at least one anode and at least one cathode; at least one separator, that separates the anodes and the cathodes; and an ionic liquid electrolyte system. The system can be a battery or one or more cells of a battery system. The ionic liquid electrolyte system comprises an ionic liquid solvent; an ether co-solvent, comprising a minority fraction, by weight, of the electrolyte; and a lithium salt. In preferred variations, the anode is a lithium metal anode and the cathode is a metal oxide cathode and the separator is a polyolefin separator.

Abstract: The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein components of inflammasomes in the cerebrospinal fluid that can be used to assess the severity of central nervous system injury in a patient are disclosed. Methods of using such protein biomarkers to determine a prognosis, direct treatment and rehabilitation efforts, and monitor response to treatment for a patient with a central nervous system injury are also described.

Abstract: The system includes a light source configured to emit light along an illumination path; a projection optical assembly disposed in the illumination path; a target disposed in the illumination path and configured to reflect the light along a collection path; a collection optical assembly disposed in the collection path; a detector disposed in the collection path and configured to detect the light reflected from the target and generate an output signal based on the detected light; and a processor in electronic communication with the detector and configured to generate a measurement of the target based on the output signal. The projection optical assembly defines a first numerical aperture at the target and the collection optical assembly defines a second numerical aperture at the target, and the first numerical aperture is slightly larger than the second numerical aperture for measurements of thick films and high aspect ratio structures.

Abstract: A system for electrical energy production from chemical reagents in a compartmentalized cell includes: at least two electrodes, comprising at least one anode and at least one cathode; at least one separator, that separates the anodes and the cathodes; and an ionic liquid electrolyte system. The system can be a battery or one or more cells of a battery system. The ionic liquid electrolyte system comprises an ionic liquid solvent; an ether co-solvent, comprising a minority fraction, by weight, of the electrolyte; and a lithium salt. In preferred variations, the anode is a lithium metal anode and the cathode is a metal oxide cathode and the separator is a polyolefin separator.

Abstract: Techniques for current biasing for memory cells are disclosed. In the illustrative embodiment, a source follower sets a voltage on a bitline of a memory cell. The current through the source follower is limited by a current mirror in series with the source follower. When additional current is required that the source follower cannot supply, a feedback transistor is activated to provide additional current. Additionally, in some embodiments, the current through the feedback transistor is copied to a current mirror, and the copied current is used to sense the state of the memory cell.

Abstract: A gate for regulating access in a transit system is disclosed. The gate comprises a movable barrier, secured storage, an RFID card reader, a first processing unit that processes a set of digits from an RFID credential, generates and transmits a hash value of the set of digits, and transmits a first bin. The gate comprises a memory, having a higher capacity than the secured storage, and a second processing unit, which sends validity information for a plurality of second bins having larger number of digits than the first bin, the validity information indicates which of the plurality of second bins is valid, check if the hash value is member of first list. If the hash value is on the first list, opening of the movable barrier is regulated and if a second bin from the plurality of second bins corresponding to the RFID credential is invalid, opening is denied.

Abstract: Systems and methods for correcting data errors in memory caused by high-temperature processing of the memory are provided. An integrated circuit (IC) die including a memory is formed. Addresses of memory locations that are susceptible to data loss when subjected to elevated temperatures are determined. Bits of data are written to the memory, where the bits of data include a set of bits written to the memory locations. The set of bits are written to a storage device of the IC die that is not susceptible to data loss when subjected to the elevated temperatures, the subset of bits comprise compressed code. At least one of the bits stored at the addresses is overwritten after subjecting the IC die to an elevated temperature. The at least one of the bits is overwritten based on the set of bits written to the storage device.

Abstract: A method of controlling a cell culture process uses hybrid predictive modeling in a model predictive controller. The method includes, for multiple time intervals, obtaining current values of cell culture attributes associated, and generating a control value for a physical input to the cell culture process. Generating the control value includes predicting future values of the cell culture attributes based on the current values, by using one or more data-driven models to predict future values of a first one or more attributes of the cell culture attributes, and using one or more first principle models to predict future values of a second one or more attributes of the cell culture attributes. Generating the control value also includes determining the control value by optimizing an objective function subject to the predicted future values. The method also includes using the control value to control the physical input to the cell culture process.

Abstract: A method of controlling a cell culture process includes, for each time interval of one or more time intervals during the cell culture process, obtaining current values of one or more cell culture attributes associated with a cell culture, predicting one or more future values of a particular cell culture attribute associated with the cell culture, and controlling one or more physical inputs to the cell culture process. Predicting the future value(s) includes applying the current values of the cell culture attribute(s), and an earlier value of at least one of the cell culture attributes, as inputs to a data-driven predictive model using historical data. Controlling the physical input(s) includes applying the future value(s) as inputs to a model predictive controller.

Abstract: From a set of point data, a set of scattered rays is constructed. From the set of scattered rays, a set of ray slopes is computed. The set of ray slopes is mapped to a corresponding set of trigonometric functions. Using an optimization method, a parameter of the set of trigonometric functions is selected. Using an inverse of the set trigonometric functions, a vehicle mass corresponding to the set of point data is computed. Based on the vehicle mass, a threshold braking distance of a collision avoidance system of the vehicle is adjusted, the threshold braking distance comprising a distance from an object predicted to collide with the vehicle. By braking the vehicle at least the threshold braking distance from the object, a predicted collision between the vehicle and the object is avoided.