Patents by Inventor Ya GAO

Ya GAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240336724
    Abstract: A reversible epoxy polymer obtainable by the reaction between at least one epoxy compound and at least one curing agent, wherein at least part of the epoxy compound contains one reversible borate moiety or derivative thereof per molecule; and/or at least part of the curing agent contains one reversible borate moiety or derivative thereof per molecule; and/or the reaction system further comprises at least one compound containing hydroxyl and epoxy group and at least one BQH-containing compound or its ester derivative, wherein said BQH-containing compound contains two or more B-QH moieties, and wherein the derivative of borate moiety represents a moiety with the oxygen in the borate moiety being replaced with other element of the sixth main group and wherein each Q is independently an element of the sixth main group.
    Type: Application
    Filed: July 21, 2022
    Publication date: October 10, 2024
    Inventors: Ya Xian Wang, Ke Ran Chen, Lulin Xie, Tao Xie, Saifudin M. Abubakar, Ning Zheng, Wenxi Gao, Qian Zhaoi, Yihan Cao
  • Patent number: 12104205
    Abstract: Provided are a PCR primer pair and an application thereof. The PCR primer pair comprises a first primer and a second primer, wherein the first primer comprises a first specific sequence, a first random sequence, and a first universal sequence, the first specific sequence is located at the 3? end of the first primer, the first random sequence is located at the 5? end of the first primer, and the first universal sequence is located between the first specific sequence and the first random sequence; the second primer comprises a second specific sequence, a second random sequence, and a second universal sequence, the second specific sequence is located at the 3? end of the second primer, the second random sequence is located at the 5? end of the second primer, and the second universal sequence is located between the second specific sequence and the second random sequence, wherein the first random sequence and the second random sequence are inversely complementary.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: October 1, 2024
    Inventors: Lin Yang, Haojun Jiang, Peng Zeng, Xuehan Zhuang, Ya Gao, Yanyan Zhang, Hui Jiang, Jing Guo, Fang Chen, Xun Xu
  • Publication number: 20240252497
    Abstract: Disclosed herein are methods for treating geographic atrophy secondary to age-related macular degeneration (AMD) and intermediate AMD in a subject. The methods include administering to the subject a therapeutically effective amount of a small molecule complement factor D inhibitor.
    Type: Application
    Filed: May 26, 2022
    Publication date: August 1, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Aleksandar Skuban, Mingjun Huang, David Boyer, Jose Rivera, Ya-Ping Ko, Xiang Gao
  • Publication number: 20240013859
    Abstract: The present invention relates to the field of biotechnology. A method and system of detecting fetal chromosomal abnormalities are disclosed.
    Type: Application
    Filed: November 27, 2020
    Publication date: January 11, 2024
    Applicant: BGI SHENZHEN
    Inventors: Yong BAI, Shujia HUANG, Ya GAO, Xin JIN
  • Publication number: 20230401974
    Abstract: A method suitable for driver takeover training of man-machine shared driving vehicle relates to the field of man-machine shared driving technology. The method includes: establishing database, situation-creation, establish a teaching model, take over training, evaluation and analysis of takeover ability. The method divides the driver's takeover behavior into a small operation action through the driver takeover training of the man-machine shared driving vehicle, defines where the driver's eyes need to observe when the takeover reminder appears, how the hands and feet need to be operated, and the sequence of these operations, solves the problems of the driver's tension and being in a flurry in the current sudden takeover reminder. In addition, through the evaluation and analysis of the takeover capability, the method can solve the problem that the existing technology cannot objectively evaluate the driver's takeover capability level.
    Type: Application
    Filed: June 14, 2023
    Publication date: December 14, 2023
    Applicants: Hefei University of Technology, Intelligent Manufacturing Institute of HFUT
    Inventors: Zhongxiang FENG, Ya GAO, Zeyang CHENG, Lei ZHANG, Zhipeng HUANG, Jiabin ZENG, Jingyu LI, Yubing ZHENG, Dianchen ZHU, Weihua ZHANG, Kang JIANG
  • Patent number: 11834716
    Abstract: Disclosed is a method for predicting whether esophageal cancer is sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody. Specifically, the method predicts by measurement of expression at the RNA level, or at the protein level, of at least one biomarker selected from SDC2, PTGES, NCF2, NOXA1, CARD6 and GNAZ in a tumor sample.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: December 5, 2023
    Assignee: Canbridge Life Sciences LTD
    Inventors: James Qun Xue, Jing Wang, Ya Gao, Huaizhong Hu
  • Patent number: 11760995
    Abstract: Provided is a PCR primer pair, comprising: a first primer and a second primer, wherein the first primer comprises a first specific sequence and a first random sequence; the first specific sequence is located on 3? end of the first primer, and the first random sequence is located on 5? end of the first primer; the second primer comprises a second specific sequence and a second random sequence, the second specific sequence is located on 3? end of the second primer, and the second random sequence is located on 5? end of the second primer; moreover, the first specific sequence and the second specific sequence are an upstream primer and a downstream primer directed to a target sequence respectively, and the first random sequence and the second random sequence are inverse complementary.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: September 19, 2023
    Assignee: MGI TECH CO., LTD.
    Inventors: Lin Yang, Ya Gao, Guodong Huang, Yicong Wang, Yuqian Wang, Yanyan Zhang, Fang Chen, Na Zhong, Hui Jiang, Xun Xu
  • Patent number: 11739319
    Abstract: Provided are a PCR primer pair and an application thereof.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: August 29, 2023
    Assignee: MGI TECH CO., LTD.
    Inventors: Lin Yang, Guodong Huang, Ya Gao, Yanyan Zhang, Haiping Zhang, Fang Chen, Haojun Jiang, Shaohong Zhang, Yuqian Wang, Yifan Xie, Hui Jiang
  • Patent number: 11719739
    Abstract: A method for testing a lifetime of a surface state carrier of a semiconductor, including the following steps, 1) a narrow pulse light source is used to emit a light pulse, and coupled to an interior of a near-field optical probe, and the near-field optical probe produces a photon-generated carrier on a surface of a semiconductor material under test through excitation. 2) The excited photon-generated carrier is concentrated on the surface of the semiconductor material, and recombination is conducted continuously with a surface state as a recombination center. 3) A change in a lattice constant is produced due to an electronic volume effect, a stress wave is produced, and a signal of the stress wave is detected in a high-frequency broadband ultrasonic testing mode. 4) Fitting calculation is conducted on the signal of the stress wave to obtain the lifetime of the surface state carrier ?c.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: August 8, 2023
    Assignee: TONGJI UNIVERSITY
    Inventors: Qian Cheng, Weiya Xie, Ya Gao, Yiming Chen, Yingna Chen, Mengjiao Zhang, Haonan Zhang, Shiying Wu
  • Publication number: 20230119741
    Abstract: A picture annotation method includes starting an annotation tool to recognize a hierarchical relationship between candidate layers in the annotation tool; acquiring an annotation event of a picture to be annotated; distributing the annotation event to at least one target master candidate layer based on the hierarchical relationship; distributing, for an arbitrary target master candidate layer, in the case where the arbitrary target master candidate layer is configured with a slave candidate layer, starting from the arbitrary target master candidate layer, the annotation event down level by level to target slave candidate layers of at least one level of the arbitrary target master candidate layer; processing the annotation event through a first target candidate layer, to which it is distributed.
    Type: Application
    Filed: December 20, 2022
    Publication date: April 20, 2023
    Inventors: Yang DING, Ya GAO
  • Patent number: 11630430
    Abstract: A latchup immune microcontroller system with a power supply and a filter designed to eliminate external risks of triggering a latchup of a microcontroller caused by the power supply; a clock circuit with a clock frequency and a layout for eliminating external risks of triggering a latchup of the microcontroller caused by a high-frequency clock signal; a reset circuit that uses an optical triggering mechanism acting as a common power supply and an isolated power supply, the power detection circuit and a discharge circuit react in chain in time, avoid risks of triggering latchups of the microcontroller caused by reset signals; an interrupt with a high priority level and the discharge circuit react in chain in time to enhance data security, and output terminals are turned off in sequence to remove external causes of latchup. An application method of an I/O port to eliminate triggers of latchup of the microcontroller.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 18, 2023
    Assignee: WUXI INSTITUTE OF TECHNOLOGY
    Inventors: Ligong Hou, Ying Xiao, Wei Wu, Ya Gao
  • Publication number: 20220367003
    Abstract: Provided in the present disclosure are a method for determining fetal nucleic acid concentration and a fetal genotyping method. According to the embodiments of the present disclosure, the method for determining cell-free fetal nucleic acid concentration includes: (1) acquiring sequencing data of a first nucleic acid sample of a pregnant woman and a reference genome sequence, the first nucleic acid sample of the pregnant woman containing cell-free fetal nucleic acids, and the sequencing data being composed of a plurality of sequencing reads; (2) selecting a predetermined region on the reference genome sequence and determining, based on the sequencing data of the first nucleic acid sample of the pregnant woman, mutation information in the predetermined region; and (3) determining the concentration of cell-free fetal nucleic acids corresponding to the predetermined region based on the mutation information in the predetermined region.
    Type: Application
    Filed: July 15, 2022
    Publication date: November 17, 2022
    Applicant: BGI SHENZHEN
    Inventors: Ruoyan CHEN, Ya GAO, Jinjin XU, Fengxia SU, Yu LIN, Xin JIN, Fang CHEN
  • Publication number: 20220043049
    Abstract: A method for testing a lifetime of a surface state carrier of a semiconductor, including the following steps, 1) a narrow pulse light source is used to emit a light pulse, and coupled to an interior of a near-field optical probe, and the near-field optical probe produces a photon-generated carrier on a surface of a semiconductor material under test through excitation. 2) The excited photon-generated carrier is concentrated on the surface of the semiconductor material, and recombination is conducted continuously with a surface state as a recombination center. 3) A change in a lattice constant is produced due to an electronic volume effect, a stress wave is produced, and a signal of the stress wave is detected in a high-frequency broadband ultrasonic testing mode. 4) Fitting calculation is conducted on the signal of the stress wave to obtain the lifetime of the surface state carrier ?c.
    Type: Application
    Filed: July 6, 2020
    Publication date: February 10, 2022
    Applicant: TONGJI UNIVERSITY
    Inventors: Qian CHENG, Weiya XIE, Ya GAO, Yiming CHEN, Yingna CHEN, Mengjiao ZHANG, Haonan ZHANG, Shiying WU
  • Patent number: 11242520
    Abstract: Provided is a method for isolating exosomal DNA, the method comprising: (i) providing a sample, wherein the sample comprises a blood sample from peripheral blood of a pregnant woman; and (ii) subjecting the sample to isolating, thus obtaining the exosomal DNA. Also provided are a method for detecting a blood sample, a method for constructing a sequencing library on a blood sample, a method for high-throughput sequencing an exosomal DNA sequencing library, a method for non-invasive prenatal gene detection, a device for non-invasive prenatal gene detection, and a kit for detecting a blood sample and use thereof.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: February 8, 2022
    Assignees: BGI SHENZHEN, MGI TECH CO., LTD.
    Inventors: Ya Gao, Sen Lu, Jia Zhao, Peng Zeng, Fang Chen, Hui Jiang
  • Publication number: 20210025006
    Abstract: The invention discloses a method for predicting whether esophageal cancer is sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody. Specifically, the method predicts by measurement of expression at the RNA level, or at the protein level, of at least one biomarker selected from SDC2, PTGES, NCF2, NOXA1, CARD6 and GNAZ in a tumor sample.
    Type: Application
    Filed: June 12, 2018
    Publication date: January 28, 2021
    Inventors: James Qun Xue, Jing Wang, Ya Gao, Huaizhong Hu
  • Publication number: 20200393804
    Abstract: A latchup immune microcontroller system with a power supply and a filter designed to eliminate external risks of triggering a latchup of a microcontroller caused by the power supply; a clock circuit with a clock frequency and a layout for eliminating external risks of triggering a latchup of the microcontroller caused by a high-frequency clock signal; a reset circuit that uses an optical triggering mechanism acting as a common power supply and an isolated power supply, the power detection circuit and a discharge circuit react in chain in time, avoid risks of triggering latchups of the microcontroller caused by reset signals; an interrupt with a high priority level and the discharge circuit react in chain in time to enhance data security, and output terminals are turned off in sequence to remove external causes of latchup. An application method of an I/O port to eliminate triggers of latchup of the microcontroller.
    Type: Application
    Filed: May 23, 2019
    Publication date: December 17, 2020
    Applicant: Wuxi Institute of Technology
    Inventors: Ligong HOU, Ying XIAO, Wei WU, Ya GAO
  • Patent number: 10816634
    Abstract: A method and system for locating a sound source are provide. The method may include detecting a sound signal of a sound by each of two audio sensors. The method may also include converting the sound signals detected by the two audio sensors from a time domain to a frequency domain. The method may further include determining a high frequency ratio of each of the sound signals in the frequency domain. The method may further include determining a direction of the sound source based on the high frequency ratios.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: October 27, 2020
    Assignee: ZHEJIANG DAHUA TECHNOLOGY CO., LTD.
    Inventors: Gang Qiao, Ya Gao
  • Publication number: 20200216874
    Abstract: Provided are a PCR primer pair and an application thereof. The PCR primer pair comprises a first primer and a second primer, wherein the first primer comprises a first specific sequence, a first random sequence, and a first universal sequence, the first specific sequence is located at the 3? end of the first primer, the first random sequence is located at the 5? end of the first primer, and the first universal sequence is located between the first specific sequence and the first random sequence; the second primer comprises a second specific sequence, a second random sequence, and a second universal sequence, the second specific sequence is located at the 3? end of the second primer, the second random sequence is located at the 5? end of the second primer, and the second universal sequence is located between the second specific sequence and the second random sequence, wherein the first random sequence and the second random sequence are inversely complementary.
    Type: Application
    Filed: June 20, 2017
    Publication date: July 9, 2020
    Inventors: Lin Yang, Haojun Jiang, Peng Zeng, Xuehan Zhuang, Ya Gao, Yanyan Zhang, Hui Jiang, Jing Guo, Fang Chen, Xun Xu
  • Publication number: 20200216838
    Abstract: Provided are a PCR primer pair and an application thereof.
    Type: Application
    Filed: June 20, 2017
    Publication date: July 9, 2020
    Inventors: Lin Yang, Guodong Huang, Ya Gao, Yanyan Zhang, Haiping Zhang, Fang Chen, Haojun Jiang, Shaohong Zhang, Yuqian Wang, Yifan Xie, Hui Jiang
  • Publication number: 20200131510
    Abstract: Provided is a PCR primer pair, comprising: a first primer and a second primer, wherein the first primer comprises a first specific sequence and a first random sequence; the first specific sequence is located on 3? end of the first primer, and the first random sequence is located on 5? end of the first primer; the second primer comprises a second specific sequence and a second random sequence, the second specific sequence is located on 3? end of the second primer, and the second random sequence is located on 5? end of the second primer; moreover, the first specific sequence and the second specific sequence are an upstream primer and a downstream primer directed to a target sequence respectively, and the first random sequence and the second random sequence are inverse complementary.
    Type: Application
    Filed: June 20, 2017
    Publication date: April 30, 2020
    Inventors: Lin Yang, Ya Gao, Guodong Huang, Yicong Wang, Yuqian Wang, Yanyan Zhang, Fang Chen, Na Zhong, Hui Jiang, Xun Xu