Patents by Inventor Ya-Huei Kuo

Ya-Huei Kuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONDITIONAL-SIRNAS AND USES THEREOF IN TREATING ACUTE MYELOID LEUKEMIA
    Publication number: 20230407308
    Abstract: Disclosed herein are conditional siRNAs activatable by CBF?-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.
    Type: Application
    Filed: March 28, 2023
    Publication date: December 21, 2023
    Applicants: CITY OF HOPE, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Guido MARCUCCI, Ya-Huei KUO, Si-Ping HAN, Lisa SCHERER, William A. GODDARD, III, John ROSSI
  • Methods of using anti-MIR126 compounds
    Patent number: 11801266
    Abstract: Provided herein are, inter alia, methods of treating red blood cell disorders and cancer using anti-miR126 compounds. The methods include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence to treat red blood cell disorders. Other methods provided herein include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence and a tyrosine kinase inhibitor to treat cancer.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: October 31, 2023
    Assignee: CITY OF HOPE
    Inventors: Guido Marcucci, Bin Zhang, Ya-Huei Kuo, Marcin Tomasz Kortylewski
  • COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
    Publication number: 20230340479
    Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
    Type: Application
    Filed: February 8, 2023
    Publication date: October 26, 2023
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
  • Conditional-siRNAS and uses thereof in treating acute myeloid leukemia
    Patent number: 11643659
    Abstract: Disclosed herein are conditional siRNAs activatable by CBF?-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: May 9, 2023
    Assignees: CITY OF HOPE, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Guido Marcucci, Ya-Huei Kuo, Si-ping Han, Lisa Scherer, William A. Goddard, III, John Rossi
  • Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
    Patent number: 11591596
    Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: February 28, 2023
    Assignee: City of Hope
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
  • Methods for forming semiconductor devices
    Patent number: 11569121
    Abstract: Methods of forming semiconductor devices are provided. The methods include: forming a trench in a substrate, wherein the trench includes a defect protruding from a bottom surface of the trench; forming a flowable material on the substrate to at least partially cover the defect; performing an etching process to reduce the height of the defect; and removing the flowable material.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: January 31, 2023
    Assignee: Vanguard International Semiconductor Corporation
    Inventors: I-Ping Lee, Kwang-Ming Lin, Chih-Cherng Liao, Ya-Huei Kuo, Pei-Yu Chang, Ya-Ting Chang, Tsung-Hsiung Lee, Zheng-Xian Wu, Kai-Chuan Kan, Yu-Jui Chang, Yow-Shiuan Liu
  • METHODS FOR FORMING SEMICONDUCTOR DEVICES
    Publication number: 20220384251
    Abstract: Methods of forming semiconductor devices are provided. The methods include: forming a trench in a substrate, wherein the trench includes a defect protruding from a bottom surface of the trench; forming a flowable material on the substrate to at least partially cover the defect; performing an etching process to reduce the height of the defect; and removing the flowable material.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 1, 2022
    Applicant: Vanguard International Semiconductor Corporation
    Inventors: I-Ping LEE, Kwang-Ming LIN, Chih-Cherng LIAO, Ya-Huei KUO, Pei-Yu CHANG, Ya-Ting CHANG, Tsung-Hsiung LEE, Zheng-Xian WU, Kai-Chuan KAN, Yu-Jui CHANG, Yow-Shiuan LIU
  • HDAC8 inhibitors for treating cancer
    Patent number: 11505523
    Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: November 22, 2022
    Assignees: CITY OF HOPE, TAIPEI MEDICAL UNIVERSITY, ACADEMIA SINICA
    Inventors: Ya-Huei Kuo, Wei-Jan Huang, Chung-I Chang
  • COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
    Publication number: 20210115443
    Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
    Type: Application
    Filed: September 2, 2020
    Publication date: April 22, 2021
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
  • Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
    Patent number: 10801026
    Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 13, 2020
    Assignee: CITY OF HOPE
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
  • METHODS OF USING ANTI-MIR126 COMPOUNDS
    Publication number: 20200281982
    Abstract: Provided herein are, inter alia, methods of treating red blood cell disorders and cancer using anti-miR126 compounds. The methods include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence to treat red blood cell disorders. Other methods provided herein include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence and a tyrosine kinase inhibitor to treat cancer.
    Type: Application
    Filed: March 5, 2020
    Publication date: September 10, 2020
    Inventors: Guido Marcucci, Bin Zhang, Ya-Huei Kuo, Marcin Tomasz Kortylewski
  • HDAC8 INHIBITORS FOR TREATING CANCER
    Publication number: 20190322617
    Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
    Type: Application
    Filed: May 7, 2019
    Publication date: October 24, 2019
    Inventors: Ya-Huei Kuo, Wei-Jan Huang, Chung-I Chang
  • HDAC8 inhibitors for treating cancer
    Patent number: 10308596
    Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: June 4, 2019
    Assignees: CITY OF HOPE, TAIPEI MEDICAL UNIVERSITY, ACADEMIA SINICA
    Inventors: Ya-Huei Kuo, Wei-Jan Huang, Chung-I Chang
  • COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
    Publication number: 20180312837
    Abstract: The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
    Type: Application
    Filed: October 14, 2016
    Publication date: November 1, 2018
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
  • HDAC8 INHIBITORS FOR TREATING CANCER
    Publication number: 20170050922
    Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
    Type: Application
    Filed: February 11, 2016
    Publication date: February 23, 2017
    Inventors: Ya-Huei Kuo, Wei-Jan Huang, Chung I-Chung
  • HDAC8 INHIBITORS FOR TREATING CANCER
    Publication number: 20160237027
    Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 18, 2016
    Inventors: Ya-Huei Kuo, Wei-Jan Huang, Chung I-Chung
  • Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
    Patent number: 7118752
    Abstract: A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for the inhibition of angiogenesis. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more malignant cells in a pharmaceutically acceptable composition, or alternatively, can be administered to one or more malignant cells by transforming the cells with exogenous nucleic acid that results in the expression of the E domain of IGF-1 in the cell.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: October 10, 2006
    Assignee: University of Connecticut
    Inventors: Thomas T. Chen, Maria J. M. Chen, Ya-Huei Kuo
  • Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
    Publication number: 20040116335
    Abstract: A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for the inhibition of angiogenesis. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more malignant cells in a pharmaceutically acceptable composition, or alternatively, can be administered to one or more malignant cells by transforming the cells with exogenous nucleic acid that results in the expression of the E domain of IGF-1 in the cell.
    Type: Application
    Filed: March 18, 2002
    Publication date: June 17, 2004
    Inventors: Thomas T. Chen, Maria J.M. Chen, Ya-Huei Kuo