Patents by Inventor Yaakov Nahmias

Yaakov Nahmias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240263147
    Abstract: The present invention provides a method of treating a disease or disorder characterized by electro-mitochondrial desynchronization in a subject in need thereof, comprising confirming the disease or disorder is characterized by electro-mitochondrial desynchronization in the subject and administering an agent that modulates mitochondrial calcium concentration and/or increases mitochondrial calcium channel activity in a tissue of the disease or disorder in the subject. Multichambered cardiac organoids comprising cardiomyocytes and endothelial cells and at least two chambers beating in synchrony are provided. Further provided are methods of using the multichambered cardiac organoid, methods of producing a cardiac organoid. Systems for making measurements within cellular aggregates or tissues and the use of same for testing therapeutic agents is also provided.
    Type: Application
    Filed: March 7, 2024
    Publication date: August 8, 2024
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yaakov NAHMIAS, Mohammad GHOSHEH, Avner EHRLICH
  • Publication number: 20240218311
    Abstract: The present disclosure provides, in part, a system for recycling a cell culture medium. Also provided is a method for recycling a cell culture medium. Such system and method can be used to produce culture meat or remove waste products from a patient's blood.
    Type: Application
    Filed: May 9, 2022
    Publication date: July 4, 2024
    Applicant: FUTURE MEAT TECHNOLOGIES LTD.
    Inventors: Yaakov NAHMIAS, Gidon HALAF, Zach SHIDLOVSKY, Guy WISSOTSKY
  • Patent number: 11913031
    Abstract: Provided are in-vitro methods and devices for sustaining a synchronized circadian rhythm in cells of a cell culture by exposing the cells to a continuous flow of medium and to at least two stimuli provided in an oscillating manner with a periodicity of 24±4 hours, wherein a first stimulus and a second stimulus of said at least two stimuli are distinct, wherein said first stimulus is provided in a first time period and reaches a first peak in a first peak time period, and wherein a second stimulus is provided in a second time period and reaches a second peak in a second peak time period, and wherein an interval between end of time period of said first peak and beginning of said time period of said second peak is at least about 2 hours.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: February 27, 2024
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Yaakov Nahmias
  • Publication number: 20230295575
    Abstract: Provided are methods of generating a metabolically mature human cell selected from the group consisting of a cardiomyocyte, a pancreatic beta cell, and a neuronal cell, using an effective concentration of a conjugated fatty acid and optionally a nonconjugated fatty acid selected from the group consisting of: a monounsaturated omega-9 fatty acid, palmitic acid, linoleic acid (LA) and a short chain fatty acid. Also provided are isolated populations of metabolically mature human cells, and methods and kits using same for selecting a compound for toxicity to the cells.
    Type: Application
    Filed: February 9, 2021
    Publication date: September 21, 2023
    Inventors: Yaakov Nahmias, Avner Ehrlich, Muneef Ayyash
  • Publication number: 20230225361
    Abstract: The technology disclosed herein concerns a process and system for producing a multi- sectional food product having an external shape and a plurality of internal sections.
    Type: Application
    Filed: July 27, 2021
    Publication date: July 20, 2023
    Inventors: Yaakov NAHMIAS, Mohammad GHOSHEH
  • Publication number: 20230201226
    Abstract: Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.
    Type: Application
    Filed: February 20, 2023
    Publication date: June 29, 2023
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Aaron COHEN, Avner EHRLICH
  • Publication number: 20230190745
    Abstract: Methods of treating coronavirus infection, or decreasing the risk of symptomatic infection, by administering a peroxisome proliferator-activated receptor alpha (PPARA) agonist or an inositol-requiring enzyme 1 (IRE1) pathway inhibitor are provided.
    Type: Application
    Filed: October 13, 2022
    Publication date: June 22, 2023
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH
  • Publication number: 20230091231
    Abstract: The present disclosure provides, in part, a cell culture medium supplement comprising at least one plant protein homologue of a serum protein, a cell culture medium comprising a serum-free base medium and one or more plant based proteins, and methods of growing cells in vitro and of producing cultured meat using the cell culture medium.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 23, 2023
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Future Meat Technologies Ltd.
    Inventors: Yaakov Nahmias, Merav Cohen, Jonathan Caspi
  • Publication number: 20230073614
    Abstract: The present disclosure provides, in part, a receptacle for filtering a liquid. The receptacle comprises a plurality of hollow fibers extending the length of the receptacle and at least one solid absorbent material occupying a space between the plurality of hollow fibers. Each hollow fiber comprises at least one opening and a lumen defined by the walls thereof, allowing the liquid to flow through. The hollow fiber walls have a porosity profile selective to passage of waste materials contained in the liquid from the lumen to the solid absorbent material(s), thereby filtering the liquid. Also provided is a system as well as a method for filtering and recycling a cell culture medium.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 9, 2023
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Future Meat Technologies Ltd.
    Inventors: Yaakov Nahmias, Guy Wissotsky
  • Publication number: 20230070582
    Abstract: The present disclosure provides, in part, a cell culture medium comprising a serum-free medium and one or more fibroblast growth factor (FGF) activators, a kit comprising the cell culture medium and instructions for use, methods of growing cells in vitro and of producing a cultured meat using the cell culture medium, and a cultured meat so produced.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 9, 2023
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov Nahmias, Muneef Ayyash, Laura Pasitka
  • Publication number: 20220241555
    Abstract: The present disclosure provides endoscopic retrograde cholangiopancreatography (ERCP) catheter systems having multiple ports and sensors configured to determine the location of the catheter's and/or guidewire's distal end as well as optional one or more magnetic bending aids, configured to aim a guidewire to the desired duct location. Further provided is a guidewire having a magnetic end and optional sensing elements. Also provided are methods of using the catheters and/or guidewires in ERCP procedures.
    Type: Application
    Filed: June 17, 2020
    Publication date: August 4, 2022
    Inventors: Mohammad GHOSHEH, Abed KHALAILEH, Yevgeni PLOTKIN, Yaakov NAHMIAS, Yoav MINTZ, Elchanan FRIED
  • Patent number: 11298151
    Abstract: Device for accessing a pericardial space of a subject in need thereof, the device including a tubular member having an atraumatic distal end and a thread formed on, and at least partially around, the outer surface of the tubular member, proximally to the distal end; wherein the thread is configured to cut, puncture and/or penetrate a pericardium.
    Type: Grant
    Filed: June 17, 2018
    Date of Patent: April 12, 2022
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Ran Eliaz, Yonathan Avraham Demma, Ziv Menshes, Or Hazan, Eva Abramov, Yaakov Nahmias, Amnon Buxboim, Yoav Kan-Tor, Yoav Mintz, Elchanan Fried
  • Publication number: 20220042975
    Abstract: Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug.
    Type: Application
    Filed: August 22, 2021
    Publication date: February 10, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Muneef AYYASH
  • Patent number: 11241147
    Abstract: A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: February 8, 2022
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Itai Hayut, Elchanan Fried, Yaakov Nahmias, Tommy Weiss-Sadan, Ariel Shrem
  • Patent number: 11234643
    Abstract: A method of measuring a Jugular Pulse property, comprising: mounting a device including an imager to the neck of a patient; imaging the Jugular vein at an imaged location using the imager; and analyzing at least one image provided by said imager to estimate at least one property of the Jugular Pulse. Optionally, said imager is a thermal imager. Optionally, the method comprises cooling tissue at said imaged location adjacent said vein using said device. In some embodiments, the device is designed to mount at a same neck axial position when disconnected and reattached and the system provided is designed to enforce the same body position to allow for comparable repeat measurements.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: February 1, 2022
    Inventor: Yaakov Nahmias
  • Publication number: 20210395690
    Abstract: An enriched population of connective tissue cells that are capable of anchorage-independent growth are provided. Compositions comprising those cells, as well as methods of producing those cells are also provided.
    Type: Application
    Filed: November 7, 2019
    Publication date: December 23, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Merav Cohen
  • Publication number: 20210379094
    Abstract: A method for reducing renal tissue toxicity in a subject caused by a kidney damaging agent is disclosed. The method comprises administering to the subject: (i) a kidney damaging agent; and (ii) an inhibitor of glucose reabsorption.
    Type: Application
    Filed: August 22, 2021
    Publication date: December 9, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Aaron COHEN
  • Publication number: 20210260311
    Abstract: There are provided herein methods, devices, kits and systems utilizing respiratory mask for delivering pressurized fluid to a subject via inhalation in an efficient manner. The fluid may include gas and/or drug and by utilizing the methods, devices, kits and systems provided, efficient drug delivery to the subject's airways is achieved. The systems, devices, kits and methods further allow inducing insufflation/exsufflation in particular in subjects having impaired suffering from low neuromotor capacity, such as spinal cord injuries (SCI) patients.
    Type: Application
    Filed: June 20, 2019
    Publication date: August 26, 2021
    Inventors: Tomer BATASH, Sigal SHAFRAN-TIKVA, Avner EHRLICH, Yaakov NAHMIAS, Amnon BUXBOIM, Yaron BLINDER, Yoav MINTZ, Elchanan FRIED, Dan ORBACH
  • Publication number: 20210139843
    Abstract: A system for growing cells comprising a bioreactor chamber for growing the cells, a delivery system delivering a perfusion solution to the bioreactor chamber for perfusion of the perfusion solution through the cells, a dialysis system having a dialyzer, a dialysate for performing a dialysis and a filter for reducing ammonia content in said dialysate, and a controller that circulates the perfusion solution through the dialyzer and the dialysate through the filter.
    Type: Application
    Filed: January 19, 2021
    Publication date: May 13, 2021
    Applicant: Hi-Tech Park, Edmond J. Safra Campus
    Inventor: Yaakov NAHMIAS
  • Publication number: 20210077444
    Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Inventors: Yaakov Nahmias, Michal Zimerman, Gahl Levy, Yishai Avior