Abstract: The invention relates to a pharmaceutical composition of a humidity-sensitive core comprising an active ingredient or pharmaceutically acceptable salt thereof; a coating over the core, the coating containing a cationic polymer; and an additional coating over the cationic polymer-containing coating, with the additional coating including an acidifying agent. Also, methods for preparing such compositions wherein a cationic polymer containing coating is applied over a humidity-sensitive core that contains the active ingredient or pharmaceutically acceptable salt thereof; and then an additional coating is applied over the cationic polymer containing coating.

Abstract: A simple yet efficient formulation for providing excellent bioefficacy, wherein the formulation includes atorvastatin or a salt thereof, in crystalline or amorphous form, with at least one pharmaceutical excipient selected to a form of atorvastatin that has beneficial properties, such as enhanced stability. These formulations do not need to include a stabilizer.