Abstract: [Problems] The present invention provides a purification method capable of more effectively removing the contaminants with physical characteristics similar to the virus from the composition containing the virus, while preventing the denaturation of the virus, than conventional methods.

Abstract: A liquid applicator for an endoscope configured to apply liquid to in vivo tissue includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a brush member provided at a distal end of the flexible tube, and a fluid channel formed in the flexible tube to supply the liquid to the brush member.

Abstract: An endoscope for magnified image observation configured to observe a magnified image of in vivo tissue comprises an insertion part configured to be inserted into a body, a magnified image observation port configured to take in the magnified image of the in vivo tissue in one of a state where the magnified image observation port is in contact with the in vivo tissue and a state where the magnified image observation port is in proximity to the in vivo tissue, the observation port being provided at a distal end of the insertion part, and a marking unit configured to mark the in vivo tissue in one of the state where the magnified image observation port is in contact with the in vivo tissue and the state where the magnified image observation port is in proximity to the in vivo tissue.

Abstract: A method of purifying a virus or viral antigen from a sample solution containing the virus or viral antigen is provided. The method comprises: preparing sintered powder of hydroxyapatite, wherein a specific surface area of particles of the sintered powder is in the range of 2.0 to 11.0 m2/g; bringing the sample solution into contact with the sintered powder to thereby adsorb the virus or viral antigen to the particles of the sintered powder; and supplying an eluant to the sintered powder to thereby elute the adsorbed virus or viral antigen from the particles of the sintered powder. The method is capable of purifying the virus from the sample solution with an uniform yielding ratio and good repeatability. Furthermore, a method of producing a vaccine of the virus or viral antigen by using the method of purifying the virus or viral antigen is provided.

Abstract: A liquid spray tool for an endoscope includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a liquid storage pouch configured to pool solution to be conveyed into the flexible tube therein, a liquid measuring pouch for measuring an amount of the solution which is arranged between a rear end of the flexible tube and a distal end of the liquid storage pouch, and a first one-way valve arranged between the liquid storage pouch and the liquid measuring pouch, the first one-way valve being configured to allow the solution to pass theretrough from an inside of the liquid storage pouch to an inside of the liquid measuring pouch, and to prevent the solution from passing theretrough from the inside of the liquid measuring pouch to the inside of the liquid storage pouch.

Abstract: A histofluorescent stain for endoscopy having good fluorescent stainability for the inner part of tissues is provided. A histofluorescent stain composition for endoscopy, containing a compound represented by the following Formula (1) wherein R1 and R2, which may be identical or different, each represent an alkyl group having 1 to 5 carbon atoms; and X? represents an anion residue.

Abstract: An endoscope for magnified image observation configured to observe a magnified image of in vivo tissue comprises an insertion part configured to be inserted into a body, a magnified image observation port configured to take in the magnified image of the in vivo tissue in one of a state where the magnified image observation port is in contact with the in vivo tissue and a state where the magnified image observation port is in proximity to the in vivo tissue, the observation port being provided at a distal end of the insertion part, and a marking unit configured to mark the in vivo tissue in one of the state where the magnified image observation port is in contact with the in vivo tissue and the state where the magnified image observation port is in proximity to the in vivo tissue.

Abstract: A liquid spray tool for an endoscope includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a liquid storage pouch configured to pool solution to be conveyed into the flexible tube therein, a liquid measuring pouch for measuring an amount of the solution which is arranged between a rear end of the flexible tube and a distal end of the liquid storage pouch, and a first one-way valve arranged between the liquid storage pouch and the liquid measuring pouch, the first one-way valve being configured to allow the solution to pass theretrough from an inside of the liquid storage pouch to an inside of the liquid measuring pouch, and to prevent the solution from passing theretrough from the inside of the liquid measuring pouch to the inside of the liquid storage pouch.

Abstract: A liquid applicator for an endoscope configured to apply liquid to in vivo tissue includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a brush member provided at a distal end of the flexible tube, and a fluid channel formed in the flexible tube to supply the liquid to the brush member.

Abstract: A cell culturing method comprises the steps of preparing a cell culture solution containing at least cells to be cultured and granular cell culture carriers; and applying a magnetic field to the cell culture solution so as to agitate the cell culture solution by the effect of the magnetic field, whereby the cells adhere to and grow on the surfaces of the cell culture carriers. Each of the carriers comprises a magnetic particle having a coating layer which is provided to cover at least a part of the surface of the magnetic particle so that the cells are allowed to adhere thereto, wherein the cell culture carriers are moved in the culture solution by the application of the magnetic field, thereby agitating the culture solution. Alternatively, the culture solution further contains magnetic particles, and the magnetic particles are moved in the culture solution by the application of the magnetic field, thereby agitating the culture solution.