Patents by Inventor Yael Mardor
Yael Mardor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100326Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.Type: ApplicationFiled: November 30, 2023Publication date: March 28, 2024Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David GUEZ, Dianne DANIELS ELMAKIAS, Yael BRESLER
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Patent number: 11931569Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.Type: GrantFiled: March 12, 2019Date of Patent: March 19, 2024Assignee: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE & SERVICES LTD.Inventors: Yael Mardor, Shirley Sharabi, Itzik Cooper, David Last, David Guez, Dianne Daniels Elmakias, Yael Bresler
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Patent number: 11933866Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: GrantFiled: August 13, 2020Date of Patent: March 19, 2024Assignees: Tel Hashomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
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Patent number: 11892530Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: GrantFiled: August 13, 2020Date of Patent: February 6, 2024Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
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Publication number: 20240029249Abstract: A method of analyzing CT data comprises receiving data describing a pre-contrast administration CT scan from a body region of the subject, and a post-contrast administration CT scan acquired from the body region at least 1 minute after initiation of administration of a contrast agent to the subject. A subtraction map is formed by subtracting one of the scans from another. The subtraction map is displayed in a manner that identifies leaking of contrast agent out of blood vessels in the region.Type: ApplicationFiled: October 4, 2023Publication date: January 25, 2024Applicant: Sheba Impact Ltd.Inventors: Yael MARDOR, David LAST, Dianne DANIELS ELMAKIAS, Shirley SHARABI, Jair BAR, Nadav FORIE, Liran LEVY, Edith Michelle MAROM
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Patent number: 10970594Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: GrantFiled: February 20, 2019Date of Patent: April 6, 2021Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels Elmakias, Yael Mardor, Shirley Sharabi, Noam Nissan, Miriam Sklair-Levy
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Publication number: 20210016084Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.Type: ApplicationFiled: March 12, 2019Publication date: January 21, 2021Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David Guez, Dianne DANIELS ELMAKIAS, Yael BRESLER
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Publication number: 20200371174Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS
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Publication number: 20200371173Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS
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Patent number: 10809323Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: GrantFiled: April 24, 2014Date of Patent: October 20, 2020Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Remot at Tel-Aviv University Ltd.Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels
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Publication number: 20190180139Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: ApplicationFiled: February 20, 2019Publication date: June 13, 2019Applicants: Tel HaShomer Medical Research Infrastructure and S ervices Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS, Yael MARDOR
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Patent number: 10275680Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: GrantFiled: October 18, 2012Date of Patent: April 30, 2019Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels, Yael Mardor
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Publication number: 20170247429Abstract: The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders.Type: ApplicationFiled: September 16, 2015Publication date: August 31, 2017Inventors: Itzik Cooper, David Guez, David Last, Yoram Shechter, Matityahu Fridkin, Yael Mardor
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Publication number: 20160109539Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: ApplicationFiled: April 24, 2014Publication date: April 21, 2016Applicants: Tel HaShomer Medical Research Infrasture and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS
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Publication number: 20150265210Abstract: A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.Type: ApplicationFiled: June 1, 2015Publication date: September 24, 2015Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: David ISRAELI, Yael Mardor, Talila Volk
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Publication number: 20150119698Abstract: Pharmaceutical composition including nanoparticles configured for enhanced phagocytosis by phagocytic cells and labeled with a near-infrared (NIR) fluorescent probe bound to the outer surface thereof, and uses thereof in the detection of activated immune cells in the central nervous system (CNS) of a subject.Type: ApplicationFiled: December 29, 2014Publication date: April 30, 2015Inventors: Sara Eyal, Shlomo Magdassi, Emma Portnoy, Jacob Zauberman, Boris Polyak, Jacob Golenser, Yael Mardor, Dana Ekstein
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Publication number: 20140270451Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: ApplicationFiled: October 18, 2012Publication date: September 18, 2014Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels, Yael Mardor
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Patent number: 8391959Abstract: Method and composition suitable for administering by direct convective interstitial infusion are disclosed. The method comprises: placing at least one direct convective interstitial infusion catheter in contact with the tissue, and pressuring the composition through the catheter. The composition is in a liquefied form having a viscosity above a predetermined value. The predetermined value is selected so as to improve infusion of the compositions into interstitial volumes of the tissue, while minimizing backflow of the compositions along an outer wall of the catheter or leakage into low resistance paths. It is demonstrated that high viscosity results in higher treatment efficiency.Type: GrantFiled: September 29, 2005Date of Patent: March 5, 2013Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Yael Mardor, Zvi Ram
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Publication number: 20120101365Abstract: A method of analyzing a blood-brain bather of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.Type: ApplicationFiled: January 3, 2012Publication date: April 26, 2012Applicants: Tel HaShamor Medical Research Infrastructure and Services Ltd., Yeda Research And Development Co. Ltd.Inventors: David Israeli, Yael Mardor, Talila Volk
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Publication number: 20110098554Abstract: A method for determining a response of a tissue to a destructive treatment is disclosed. The method comprises providing magnetic resonance images of the tissue, and using the magnetic resonance images for determining the response of the tissue to the destructive treatment. Also disclosed is a method for monitoring convection during direct convective interstitial infusion using a pharmaceutical composition which comprises a therapeutic agent and an MRI contrast agent.Type: ApplicationFiled: September 29, 2005Publication date: April 28, 2011Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Medical Research Fund of Tel Aviv Sourasky Medical CenterInventors: Yael Mardor, Zvi Ram