Patents by Inventor Yafeng ZHAN

Yafeng ZHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11866413
    Abstract: Disclosed is a method for refining 5-fluorouracil, comprising the following steps: dissolving 5-fluorouracil in an organic solvent, preferably DMSO, heating and stirring until dissolved; naturally cooling the filtrate until a crystal is precipitated; filtering, washing a filter cake using a polar solvent, and draining and drying under reduced pressure. By using the new refining method, the content of impurities in 5-fluorouracil may be reduced to less than 0.01%, the product purity is more than 99.98%, and the refining yield is higher than 70%. In addition, the refining method of the present invention has a simple process, convenient operation, low production costs, high product purity, a stable process, and is suitable for industrial production.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 9, 2024
    Assignee: SHANGHAI XUDONG HAIPU PHARMACEUTICAL CO., LTD
    Inventors: Xiaolin Chen, Pengfei Gao, Yike Yang, Yi Liang, Yafeng Zhan
  • Publication number: 20220348548
    Abstract: Disclosed is a method for refining 5-fluorouracil, comprising the following steps: dissolving 5-fluorouracil in an organic solvent, preferably DMSO, heating and stirring until dissolved; naturally cooling the filtrate until a crystal is precipitated; filtering, washing a filter cake using a polar solvent, and draining and drying under reduced pressure. By using the new refining method, the content of impurities in 5-fluorouracil may be reduced to less than 0.01%, the product purity is more than 99.98%, and the refining yield is higher than 70%. In addition, the refining method of the present invention has a simple process, convenient operation, low production costs, high product purity, a stable process, and is suitable for industrial production.
    Type: Application
    Filed: January 10, 2020
    Publication date: November 3, 2022
    Inventors: Xiaolin Chen, Pengfei Gao, Yike Yang, Yi Liang, Yafeng Zhan
  • Publication number: 20220130540
    Abstract: Provided are a method and system for individualized prediction of mental illness on the basis of brain function map monkey-human cross-species migration, and a method for determining a mental illness prediction model. The method for determining a mental illness prediction model comprises the steps: (a) data acquisition; (b) preprocessing; (c) brain region selection; (d) feature construction; (e) feature screening; and (f) modeling prediction. The method and system are non-invasive and have high accuracy, high sensitivity, good specificity, and are convenient to popularize.
    Type: Application
    Filed: November 4, 2019
    Publication date: April 28, 2022
    Applicant: CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Zheng WANG, Yafeng ZHAN