Abstract: A composition of herbal medicine which can be used for shrimp disease treatment, includes the following ingredients: Lobelia chinensis Lour, Folium Loropetali, composition X and fishmeal, crude protein, soymeal, powder, dextrin, glucose and minerals. The composition is used in manufacturing three different medicaments and for the different medicaments, the composition X includes one or more ingredients of astragalus, vitexin flower, elephantopus flower and Coptis chinensis leaf. The composition and the medicaments are effective in treating the shrimp infectious disease, protozoa and improving the shrimp immune system.