Patents by Inventor Yahui Ma

Yahui Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTAL FORM OF 1,2,3-TRIAZOLO[1,5-A]PYRAZINES DERIVATIVE AND PREPARATION METHOD FOR CRYSTAL FORM
    Publication number: 20220081446
    Abstract: The present invention provides a crystal form of a 1,2,3-triazolo[1,5-a]pyrazines derivative and a preparation method for the crystal form. Specifically, the present invention provides a crystal form of a compound (S)-N5-(3,4-difluorophenyl)-6-methyl-N3-((R)-1,1,1-trifluoropropan-2-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-c]pyrazine-3,5(4H)-dimethylformamide and a preparation method for the crystal form. The prepared crystal form has good stability and clinical application value.
    Type: Application
    Filed: January 22, 2020
    Publication date: March 17, 2022
    Applicants: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Long HAN, Qiyun SHAO, Jun FENG, Feng HE, Yahui MA, Miaomiao ZHAO, Zhenxing DU, Jie WANG
  • Crystal forms of oxypyridine amide derivative and preparation method therefor
    Patent number: 11225462
    Abstract: The present invention relates to crystal forms of an oxypyridine amide derivative and a preparation method therefor. In particular, the present invention relates to crystal forms A, B, C, D, E and F of a compound represented by formula (I) and a preparation method therefor. The crystal forms of the compound represented by formula (I) as described in the present invention have good crystal form stability and may be better for clinical use.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: January 18, 2022
    Assignees: JIANGSU HENGRUI MEDICINE CO., LTD., SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
    Inventors: Yahui Ma, Haoyu Zhang, Long Han, Qiyun Shao, Zhenxing Du, Jie Wang, Jun Feng, Feng He
  • Salt of phenylpropionamide derivative and preparation method therefor
    Patent number: 11180530
    Abstract: A salt of a phenylpropionamide derivative and a preparation method therefor is described. Specifically, the salt of the compound of formula (I) has good stability, and can be better used in clinical treatment. The process for preparing the salt of the compound of formula (I) of the present invention is simple and easy to operate.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 23, 2021
    Assignees: Jiangsu Hengrui Medicine CO., LTD., Shanghai Hengrui Pharmaceutical CO., LTD
    Inventors: Lin Wang, Jingquan Ye, Qiyun Shao, Jun Feng, Feng He, Xiaoli Cao, Yahui Ma
  • CRYSTAL FORM OF MALEATE OF TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR
    Publication number: 20210355109
    Abstract: Provided are a crystal form of a maleate of a tyrosine kinase inhibitor and a preparation method therefor. Specifically, provided are I crystal form, a II crystal form, a III crystal form, a IV crystal form and a V crystal form of the compound as shown in formula (I) and a preparation method therefor. The new crystal form has a good stability, thereby making same better to use in clinical treatments.
    Type: Application
    Filed: October 21, 2019
    Publication date: November 18, 2021
    Applicant: JIANGSU HENGRUI MEDICINE CO., LTD.
    Inventors: Zhenjun QIU, Quanliang ZHANG, Yanli WEI, Yongxing CAO, Junran YANG, Yahui MA, Zhenxing DU, Jie WANG
  • CRYSTAL FORMS OF OXYPYRIDINE AMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR
    Publication number: 20210122714
    Abstract: The present invention relates to crystal forms of an oxypyridine amide derivative and a preparation method therefor. In particular, the present invention relates to crystal forms A, B, C, D, E and F of a compound represented by formula (I) and a preparation method therefor. The crystal forms of the compound represented by formula (I) as described in the present invention have good crystal form stability and may be better for clinical use.
    Type: Application
    Filed: July 1, 2019
    Publication date: April 29, 2021
    Applicants: JIANGSU HENGRUI MEDICINE CO., LTD., SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD
    Inventors: Yahui MA, Haoyu ZHANG, Long HAN, Qiyun SHAO, Zhenxing DU, Jie WANG, Jun FENG, Feng HE
  • Salt of phenylpropionamide derivative and preparation method therefor
    Publication number: 20200331963
    Abstract: The present invention provides a salt of a phenylpropionamide derivative and a preparation method therefor. The present invention specifically provides an acetate, hydrochloride, phosphate, citrate, benzoate, or fumarate of 4-amino-1-((2R,5R,8R,14R)-2-(4-aminobutyl)-8-benzyl-5-isobutyl-4,7,10-trioxo-14-phenyl-3,6,9,12-tetraazapentadecan-1-acyl)piperidine-4-carboxylic acid, and a preparation method therefor. The salt of the compound of formula (I) of the present invention has good stability, and the simple process thereof facilitates easy operation. The invention is better suited for clinical treatment.
    Type: Application
    Filed: December 5, 2018
    Publication date: October 22, 2020
    Inventors: Lin Wang, Jingquan Ye, Qiyun Shao, Jun Feng, Feng He, Xiaoli Cao, Yahui Ma