Patents by Inventor Yair Devash

Yair Devash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide compositions for the treatment and prevention of HIV infection
    Publication number: 20030194411
    Abstract: The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate compositions. The peptide conjugate compositions comprise peptides with amino acid sequences similar to the gp 120 principal neutralizing domain (PND) of HIV, gp41, and Nef (p27) of HIV and carriers which enhance immunogenicity. The peptide conjugate compositions of the present invention may comprise a multivalent cocktail of several different peptide conjugates. Also provided by present invention is a method for reducing the level of HIV titers in a mammal by administering to the mammal a peptide composition of the present invention in an amount effective to reduce the level of HIV titers. The peptide conjugate compositions of the present invention induce prolonged antibody response in serum, a high level of antibody in the mucosa, and the production of cytotoxic lymphocytes.
    Type: Application
    Filed: August 6, 2002
    Publication date: October 16, 2003
    Inventors: Arye Rubinstein, Barry R. Bloom, Yair Devash, Stanley J. Cryz
  • Peptide compositions for the treatment of HIV infection
    Patent number: 6447778
    Abstract: The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate compositions. The peptide conjugate compositions comprise peptides with amino acid sequences similar to the gp120 principal neutralizing domain (PND) of HIV, gp41, and Nef (p27) of HIV and carriers which enhance immunogenicity. The peptide conjugate compositions of the present invention may comprise a multivalent cocktail of several different peptide conjugates. Also provided by present invention is a method for reducing the level of HIV titers in a mammal by administering to the mammal a peptide composition of the present invention in an amount effective to reduce the level of HIV titers. The peptide conjugate compositions of the present invention induce prolonged antibody response in serum, a high level of antibody in the mucosa, and the production of cytotoxic lymphocytes.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: September 10, 2002
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Arye Rubinstein, Barry R. Bloom, Yair Devash, Stanley J. Cryz
  • Peptide compositions for the treatment of HIV
    Patent number: 6139843
    Abstract: The present invention provides for peptide conjugate compositions, methods of using the peptide conjugate compositions, and pharmaceutical compositions comprising the peptide conjugate compositions. The peptide conjugate compositions comprise peptides with amino acid sequences similar to the gp120 principal neutralizing domain (PND) of HIV, gp41, and Nef (p27) of HIV and carriers which enhance immunogenicity. The peptide conjugate compositions of the present invention may comprise a multivalent cocktail of several different peptide conjugates. Also provided by present invention is a method for reducing the level of HIV titers in a mammal by administering to the mammal a peptide composition of the present invention in an amount effective to reduce the level of HIV titers. The peptide conjugate compositions of the present invention induce prolonged antibody response in serum, a high level of antibody in the mucosa, and the production of cytotoxic lymphocytes.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: October 31, 2000
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Arye Rubinstein, Barry R. Bloom, Yair Devash, Stanley J. Cryz
  • Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
    Patent number: 4855304
    Abstract: Potent plant antivirals are disclosed along with their method of use. These antivirals, 5',5'- or 2',5'- or 3',5'-pyrophosphorylated-dinucleotides, are specifically shown to inhibit tobacco mosaic virus (TMV) replication in tobacco plants when applied to the leaves or through the roots of these plants. These antiviral compounds can also be used to treat a variety of other plants, as disclosed herein, which are susceptible to a broad range of viruses.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: August 8, 1989
    Assignee: Repligen Corporation
    Inventor: Yair Devash
  • Inhibition of plant viruses with oligonucleotides
    Patent number: 4654326
    Abstract: Viral diseases in plant parts, such as leaves are inhibited by applying to the plants an effective amount of an agent comprising 2', 5'-oligonucleotide, such as 2, 5-A, linked in 2', 5'-phosphodiester bond. The agent is provided in a vehicle such as a liquid or a powder, and is present in the vehicle in an effective amount at a concentration less than 1.times.10.sup.-8 M.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: March 31, 1987
    Inventor: Yair Devash